Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Svetlana Favelyukis"'
Autor:
Fang Zhang, Dennis Rentzeperis, Francine M. Gregoire, Holly J. Clarke, Brian Edward Lavan, Thomas A. Gustafson, Svetlana Favelyukis, Dorothy D. Sears, L. Edward Clemens, James M. Lenhard, Yi Mu
Publikováno v:
Molecular Endocrinology. 23:975-988
MBX-102/JNJ39659100 (MBX-102) is in clinical development as an oral glucose-lowering agent for the treatment of type 2 diabetes. MBX-102 is a nonthiazolidinedione (TZD) selective partial agonist of peroxisome proliferator-activated receptor (PPAR)-γ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d5a0582832e3857944e294f2920342f
https://doi.org/10.1210/me.2008-0473
https://doi.org/10.1210/me.2008-0473
Autor:
Svetlana Favelyukis, M. T. Audrey Nguyen, David Patsouris, Jerrold M. Olefsky, Takeshi Imamura, Wei Liao, Takeshi Yoshizaki, Inder M. Verma
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism. 293:E219-E227
Peroxisome proliferator-activated receptor-gamma (PPAR-gamma) plays a critical role in regulating insulin sensitivity and glucose homeostasis. In this study, we identified highly efficient small interfering RNA (siRNA) sequences and used lentiviral s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69ba2ecf836297a664a9eb5d176dc520
https://doi.org/10.1152/ajpendo.00695.2006
https://doi.org/10.1152/ajpendo.00695.2006
Autor:
Juan I. Sbodio, Nai-Wen Chi, M. T. Audrey Nguyen, Hiroaki Satoh, Bassil I. Dahiyat, Svetlana Favelyukis, Jonathan Zalevsky, Takeshi Imamura, Jerrold M. Olefsky, Jennie L. Babendure
Publikováno v:
Journal of Biological Chemistry. 280:35361-35371
Lipid infusion and high fat feeding are established causes of systemic and adipose tissue insulin resistance. In this study, we treated 3T3-L1 adipocytes with a mixture of free fatty acids (FFAs) to investigate the molecular mechanisms underlying fat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fc1a52652e23b3084f91769f0a523ab
https://doi.org/10.1074/jbc.m504611200
https://doi.org/10.1074/jbc.m504611200
Autor:
Ru Liu-Bryan, Anh-Khoi Nguyen, Alan Jenn, Christopher K. Glass, Donna Reichart, Jerrold M. Olefsky, M. T. Audrey Nguyen, Svetlana Favelyukis, Peter A. Scott, Jaap G. Neels
Publikováno v:
The Journal of biological chemistry. 282(48)
Obesity and type 2 diabetes are characterized by decreased insulin sensitivity, elevated concentrations of free fatty acids (FFAs), and increased macrophage infiltration in adipose tissue (AT). Here, we show that FFAs can cause activation of RAW264.7
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::399b0b67e0b79c2d508bdc99264a0d13
https://pubmed.ncbi.nlm.nih.gov/17916553
https://pubmed.ncbi.nlm.nih.gov/17916553
Autor:
Thomas A. Gustafson, Yi Mu, L. Edward Clemens, Francine M. Gregoire, James M. Lenhard, Dorothy D. Sears, Svetlana Favelyukis, Dennis Rentzeperis, Brian Edward Lavan, Fang Zhang, Holly J. Clarke
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 94:2210-2210
MBX-102/JNJ39659100 (MBX-102) is in clinical development as an oral glucose lowering agent for the treatment of type 2 diabetes. MBX-102 is a non-thiazolidinedione (TZD) selective partial agonist of PPAR-γ that is differentiated from the TZDs struct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c618b98c459d08f19065b9720a4dca7
https://doi.org/10.1210/jcem.94.6.9995
https://doi.org/10.1210/jcem.94.6.9995