Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Svetlana Bolshakov"'
Autor:
Guy Lahat, Quan-Sheng Zhu, Kai-Lieh Huang, Suizhao Wang, Svetlana Bolshakov, Jeffery Liu, Keila Torres, Robert R Langley, Alexander J Lazar, Mien Chie Hung, Dina Lev
Publikováno v:
PLoS ONE, Vol 5, Iss 4, p e10105 (2010)
BACKGROUND:Vimentin is a ubiquitous mesenchymal intermediate filament supporting mechano-structural integrity of quiescent cells while participating in adhesion, migration, survival, and cell signaling processes via dynamic assembly/disassembly in ac
Externí odkaz:
https://doaj.org/article/8c3158fe88f7442b89ccc14528d6fe98
Autor:
Angela D. Bhalla, Sharon M. Landers, Anand K. Singh, Jace P. Landry, Michelle G. Yeagley, Gabryella S.B. Myerson, Cristian B. Delgado-Baez, Stephanie Dunnand, Theresa Nguyen, Xiaoyan Ma, Svetlana Bolshakov, Brian A. Menegaz, Salah-Eddine Lamhamedi-Cherradi, Xizeng Mao, Xingzhi Song, Alexander J. Lazar, Ian E. McCutcheon, John M. Slopis, Joseph A. Ludwig, Dina C. Lev, Kunal Rai, Keila E. Torres
Publikováno v:
Laboratory Investigation. 102:658-666
Undifferentiated pleomorphic sarcoma (UPS) and malignant peripheral nerve sheath tumor (MPNST) are aggressive soft tissue sarcomas that do not respond well to current treatment modalities. The limited availability of UPS and MPNST cell lines makes it
Autor:
Raphael E. Pollock, Dina Lev, Xiaoli Zhang, Svetlana Bolshakov, Kate Lynn Bill, Hemant Kumar Bid, Chad J. Creighton, Dennis Ruder, Ryan Lam, Yechun Song, Gonzalo Lopez
HDAC1 and HDAC2 siRNA knockdown reduce EZH2 protein expression.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72142117af90e738bb7579b1c1da0270
https://doi.org/10.1158/1541-7786.22512039
https://doi.org/10.1158/1541-7786.22512039
Autor:
Raphael E. Pollock, Dina Lev, Xiaoli Zhang, Svetlana Bolshakov, Kate Lynn Bill, Hemant Kumar Bid, Chad J. Creighton, Dennis Ruder, Ryan Lam, Yechun Song, Gonzalo Lopez
Epithelioid sarcoma is a rare neoplasm uniquely comprised of cells exhibiting both mesenchymal and epithelial features. Having propensity for local and distant recurrence, it poses a diagnostic dilemma secondary to pathologic complexity. Patients hav
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::94bd0afb517d923a7c46b61ee9907ee0
https://doi.org/10.1158/1541-7786.c.6540108.v1
https://doi.org/10.1158/1541-7786.c.6540108.v1
Autor:
Raphael E. Pollock, Dina Lev, Xiaoli Zhang, Svetlana Bolshakov, Kate Lynn Bill, Hemant Kumar Bid, Chad J. Creighton, Dennis Ruder, Ryan Lam, Yechun Song, Gonzalo Lopez
Supplemental Data Figure Legends 1-3, Supplemental Table 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2903168cc0dfa44bba2f924aabc86d1
https://doi.org/10.1158/1541-7786.22512048
https://doi.org/10.1158/1541-7786.22512048
Autor:
Raphael E. Pollock, Dina Lev, Xiaoli Zhang, Svetlana Bolshakov, Kate Lynn Bill, Hemant Kumar Bid, Chad J. Creighton, Dennis Ruder, Ryan Lam, Yechun Song, Gonzalo Lopez
HDACi abrogates ES colony formation.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::448db6b4ab4ea51ba1697ec133bb6bd8
https://doi.org/10.1158/1541-7786.22512045.v1
https://doi.org/10.1158/1541-7786.22512045.v1
Autor:
Raphael E. Pollock, Dina Lev, Xiaoli Zhang, Svetlana Bolshakov, Kate Lynn Bill, Hemant Kumar Bid, Chad J. Creighton, Dennis Ruder, Ryan Lam, Yechun Song, Gonzalo Lopez
The Molecular Signatures Database (MSigDB) analysis associates EZH2 transcriptional targets with HDACi-induced differential expression (NUYTTEN_EZH2_TARGETS_UP, genes up-regulated in prostate cancer cell line PC3 after EZH2 siRNA knockdown.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a56b5796e0277e7a7b485e79cc835400
https://doi.org/10.1158/1541-7786.22512036.v1
https://doi.org/10.1158/1541-7786.22512036.v1
Autor:
Raphael E. Pollock, Dina Lev, Xiaoli Zhang, Svetlana Bolshakov, Kate Lynn Bill, Hemant Kumar Bid, Chad J. Creighton, Dennis Ruder, Ryan Lam, Yechun Song, Gonzalo Lopez
HDACi reduces EZH2 RNA and protein expression.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9979b409030e30028043d93198b2e7c8
https://doi.org/10.1158/1541-7786.22512042.v1
https://doi.org/10.1158/1541-7786.22512042.v1
Autor:
Dina Lev, Alexander J. Lazar, Belinda Hernandez, Jun Liu, Guy Lahat, Suizhau Wang, Roman Belousov, Svetlana Bolshakov, Theresa Nguyen, Juehui Liu, Eric D. Young, Xianbiao Xie, Markus P. Ghadimi, Gonzalo Lopez, Katelynn Bill, Quan-Sheng Zhu, Keila E. Torres
Purpose: MET signaling has been suggested a potential role in malignant peripheral nerve sheath tumors (MPNST). Here, MET function and blockade were preclinically assessed.Experimental Design: Expression levels of MET, its ligand hepatocyte growth fa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39688846d1130a730517f411569491d0
https://doi.org/10.1158/1078-0432.c.6518190
https://doi.org/10.1158/1078-0432.c.6518190
Autor:
Raphael E. Pollock, Dina Lev, Hemant Bid, Abbie Zewdu, Gonzalo Lopez, Danielle Braggio, Lucia Casadei, Bethany C. Prudner, Alexander J. Lazar, Laurent Debussche, Cedric Barriere, Svetlana Bolshakov, Chad J. Creighton, XiaoYen Ma, Isabelle Meaux, Jeannine Garnett, Kate Lynn J. Bill
Supplementary Data from SAR405838: A Novel and Potent Inhibitor of the MDM2:p53 Axis for the Treatment of Dedifferentiated Liposarcoma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05d251c68748b14a1893c47d82ed1439
https://doi.org/10.1158/1078-0432.22457193
https://doi.org/10.1158/1078-0432.22457193