Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Svetlana A Shestopal"'
Autor:
Haarin Chun, James H. Kurasawa, Philip Olivares, Ekaterina S. Marakasova, Svetlana A. Shestopal, Gabriela U. Hassink, Elena Karnaukhova, Mary Migliorini, Juliet O. Obi, Ally K. Smith, Patrick L. Wintrode, Prasannavenkatesh Durai, Keunwan Park, Daniel Deredge, Dudley K. Strickland, Andrey G. Sarafanov
Publikováno v:
Journal of Thrombosis and Haemostasis. 20:2255-2269
Deficiency in blood coagulation factor VIII (FVIII) results in life-threating bleeding (hemophilia A) treated by infusions of FVIII concentrates. To improve disease treatment, FVIII has been modified to increase its plasma half-life, which requires u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbe192fa0a6be1b8e8c0b22fd5c2adbb
https://doi.org/10.1111/jth.15817
https://doi.org/10.1111/jth.15817
Characterization of protein unable to bind von Willebrand factor in recombinant factor VIII products
Autor:
Philip Olivares, John R Pettersson, Mikhail V Ovanesov, Stepan S Surov, Ekaterina S. Marakasova, Wells W. Wu, Rong-Fong Shen, Andrey G Sarafanov, Haarin Chun, Svetlana A Shestopal
Publikováno v:
Journal of thrombosis and haemostasis : JTHREFERENCES. 19(4)
Background Therapeutic products with coagulation factor VIII (FVIII) have a wide range of specific activities, implying presence of protein with altered structure. Previous studies showed that recombinant FVIII products (rFVIII) contain a fraction (F
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bc12dd0a0e89dc1ca4754799fd8d2a2
https://pubmed.ncbi.nlm.nih.gov/33527662
https://pubmed.ncbi.nlm.nih.gov/33527662
Autor:
Svetlana A Shestopal, Andrey G Sarafanov, Ekaterina S. Marakasova, James H. Kurasawa, Haarin Chun, Elena Karnaukhova, Dudley K. Strickland, Nancy E. Hernandez, Philip Olivares, Gabriela U. Hassink
Publikováno v:
The Journal of Biological Chemistry
The low-density lipoprotein receptor (LDLR) family of receptors are cell-surface receptors that internalize numerous ligands and play crucial role in various processes, such as lipoprotein metabolism, hemostasis, fetal development, etc. Previously, r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdca564b873d705b6974821f416bc0a1
https://doi.org/10.1016/j.jbc.2021.100842
https://doi.org/10.1016/j.jbc.2021.100842
Autor:
Jian-Jiang Hao, John H. McVey, Yideng Liang, James H. Kurasawa, Mikhail V Ovanesov, Elena Karnaukhova, Timothy K Lee, M. Lin, Andrey G Sarafanov, Svetlana A Shestopal
Publikováno v:
Journal of Thrombosis and Haemostasis. 15:709-720
Essentials Recombinant factor VIII (FVIII) is known to be expressed at a low level in cell culture. To increase expression, we used codon-optimization of a B-domain deleted FVIII (BDD-FVIII). This resulted in 7-fold increase of the expression level i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11b64994cd77134f5a7ed53cb239a293
https://doi.org/10.1111/jth.13632
https://doi.org/10.1111/jth.13632
Autor:
Mikhail V Ovanesov, John R Pettersson, Rong-Fong Shen, Timothy K Lee, Svetlana A Shestopal, Andrey G Sarafanov, Philip Olivares, Wells W. Wu, Haarin Chun, Stepan S Surov, Ekaterina S. Marakasova
Publikováno v:
Blood. 136:25-26
Introduction Therapeutic products with blood coagulation factor VIII (FVIII) have a wide range of protein contents per activity unit (or IU/mg, specific activity), available from previous studies (Lin et al, 2004; Butenas et al, 2009) and the prescri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ccec7b8838b1c123f87f761be9ce5186
https://doi.org/10.1182/blood-2020-133286
https://doi.org/10.1182/blood-2020-133286
Mapping the Binding Region on the Low Density Lipoprotein Receptor for Blood Coagulation Factor VIII
Autor:
James H. Kurasawa, Svetlana A Shestopal, Andrey G Sarafanov, Elena Karnaukhova, Timothy K Lee, Evi Struble
Publikováno v:
Journal of Biological Chemistry. 288:22033-22041
Low density lipoprotein receptor (LDLR) was shown to mediate clearance of blood coagulation factor VIII (FVIII) from the circulation. To elucidate the mechanism of interaction of LDLR and FVIII, our objective was to identify the region of the recepto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b048310bb6884adf212e781b105ec347
https://doi.org/10.1074/jbc.m113.468108
https://doi.org/10.1074/jbc.m113.468108
Autor:
Andrey G Sarafanov, James H. Kurasawa, Svetlana A Shestopal, Timothy K Lee, Naveen Jha, Mikhail V Ovanesov
Publikováno v:
Protein Expression and Purification. 88:201-206
A recombinant single-chain variable antibody fragment (scFv) KM33 was previously described as a ligand that can inhibit the function of blood coagulation factor VIII (FVIII). This scFv was previously derived from an individual with anti-FVIII antibod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f89fdbbd56d1a41fb97c9e04ccdddb73
https://doi.org/10.1016/j.pep.2012.12.008
https://doi.org/10.1016/j.pep.2012.12.008
Autor:
N. K. Jha, Yideng Liang, M. J. Gourley, Mikhail V Ovanesov, Svetlana A Shestopal, Andrey G Sarafanov, Samuel A. Woodle, Milton C. Weinstein
Publikováno v:
Haemophilia : the official journal of the World Federation of Hemophilia. 22(5)
Introduction The thrombin generation test (TGT) is used both as a global haemostasis assay, and to compare activities of coagulation factor concentrates that have been spiked into patient plasma. However, TGT has not been systematically optimized to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b91db6daf62fd40f177b4be696f5866
https://pubmed.ncbi.nlm.nih.gov/27038076
https://pubmed.ncbi.nlm.nih.gov/27038076
Autor:
Mikhail V Ovanesov, Svetlana A Shestopal, Leonid A. Parunov, Timothy K Lee, Andrey G Sarafanov
Publikováno v:
Blood. 132:1170-1170
Introduction Replacement therapy for Hemophilia A requires frequent infusions of Factor VIII (FVIII) due to its relatively short half-life of ~12 h in plasma. Previous attempts to extend this half-life by genetic and chemical modification of FVIII me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ed36f18dcafcf9c013c28054ebcf7597
https://doi.org/10.1182/blood-2018-99-115455
https://doi.org/10.1182/blood-2018-99-115455
Autor:
Robert Grabski, Tomasz Szul, Svetlana A. Shestopal, Martin Lowe, Elizabeth Sztul, Susan A. Lyons, Yuichi Morohashi
Publikováno v:
Journal of Cell Science. 120:3929-3940
COPI recruitment to membranes appears to be essential for the biogenesis of the Golgi and for secretory trafficking. Preventing COPI recruitment by expressing inactive forms of the ADP-ribosylation factor (ARF) or the ARF-activating guanine nucleotid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb4b7af58393c2d9d37e404249ad5e88
https://doi.org/10.1242/jcs.010769
https://doi.org/10.1242/jcs.010769