Výsledky vyhledávání - "Svetlana, Makovets"

Akademický článek

The Inability to Disassemble Rad51 Nucleoprotein Filaments Leads to Aberrant Mitosis and Cell Death

Autor: Tadas Andriuskevicius, Anton Dubenko, Svetlana Makovets

Publikováno v: Biomedicines, Vol 11, Iss 5, p 1450 (2023)

The proper maintenance of genetic material is essential for the survival of living organisms. One of the main safeguards of genome stability is homologous recombination involved in the faithful repair of DNA double-strand breaks, the restoration of c

Externí odkaz: https://doaj.org/article/c1a65d2435924993a15b308af2c7dad1

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Akademický článek

Break-induced replication requires DNA damage-induced phosphorylation of Pif1 and leads to telomere lengthening.

Autor: Yulia Vasianovich, Lea A Harrington, Svetlana Makovets

Publikováno v: PLoS Genetics, Vol 10, Iss 10, p e1004679 (2014)

Broken replication forks result in DNA breaks that are normally repaired via homologous recombination or break induced replication (BIR). Mild insufficiency in the replicative ligase Cdc9 in budding yeast Saccharomyces cerevisiae resulted in a popula

Externí odkaz: https://doaj.org/article/cf35f729cb954b03940253b30a41241b

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Aneuploidy as a mechanism of adaptation to telomerase insufficiency

Autor: Caroline Millet, Svetlana Makovets

Publikováno v: Current Genetics
Millet, C & Makovets, S 2016, ' Aneuploidy as a mechanism of adaptation to telomerase insufficiency ', Current Genetics, vol. 62, no. 3, pp. 557-64 . https://doi.org/10.1007/s00294-015-0559-x

Cells’ survival is determined by their ability to adapt to constantly changing environment. Adaptation responses involve global changes in transcription, translation, and posttranslational modifications of proteins. In recent years, karyotype chang

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b61778e1274a82da4ce1d420a342042
https://doi.org/10.1007/s00294-015-0559-x

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Unloading of homologous recombination factors is required for restoring double-stranded DNA at damage repair loci

Autor: Yulia, Vasianovich, Veronika, Altmannova, Oleksii, Kotenko, Matthew D, Newton, Lumir, Krejci, Svetlana, Makovets

Publikováno v: The EMBO Journal

Cells use homology‐dependent DNA repair to mend chromosome breaks and restore broken replication forks, thereby ensuring genome stability and cell survival. DNA break repair via homology‐based mechanisms involves nuclease‐dependent DNA end rese

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b13882514f7a1f39ad531e76c47937d3
https://pubmed.ncbi.nlm.nih.gov/27932447

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Tel2 mediates activation and localization of ATM/Tel1 kinase to a double-strand break

Autor: Elizabeth H. Blackburn, Carol M. Anderson, Dana L. Smith, Andrej Sali, Dmitry Korkin, Jeffrey J. Seidel, Svetlana Makovets

Publikováno v: Anderson, C M, Korkin, D, Smith, D L, Makovets, S, Seidel, J J, Sali, A & Blackburn, E H 2008, ' Tel2 mediates activation and localization of ATM/Tel1 kinase to a double-strand break ', Genes & Development, vol. 22, no. 7, pp. 854-859 . https://doi.org/10.1101/gad.1646208

The kinases ATM and ATR (Tel1 and Mec1 in the yeast Saccharomyces cerevisiae) control the response to DNA damage. We report that S. cerevisiae Tel2 acts at an early step of the TEL1/ATM pathway of DNA damage signaling. We show that Tel1 and Tel2 inte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee2814169b7c99197c79ab9889eb40b3
https://doi.org/10.1101/gad.1646208

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The Telotype Defines the Telomere State inSaccharomyces cerevisiaeand Is Inherited as a Dominant Non-Mendelian Characteristic in Cells Lacking Telomerase

Autor: Svetlana Makovets, Elizabeth H. Blackburn, Tanya L. Williams

Publikováno v: Makovets, S, Williams, T L & Blackburn, E H 2008, ' The telotype defines the telomere state in Saccharomyces cerevisiae and is inherited as a dominant non-Mendelian characteristic in cells lacking telomerase ', Genetics, vol. 178, no. 1, pp. 245-57 . https://doi.org/10.1534/genetics.107.083030

Telomeres are an unusual component of the genome because they do not encode genes, but their structure and cellular maintenance machinery (which we define as “telotype”) are essential for chromosome stability. Cells can switch between different p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68e49871efec0772b37e1d68dd89c825
https://doi.org/10.1534/genetics.107.083030

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Cell populations can use aneuploidy to survive telomerase insufficiency

Autor: Darya Ausiannikava, Svetlana Makovets, Caroline Millet, Sander Granneman, Thierry Le Bihan

Publikováno v: Millet, C, Ausiannikava, D, Le Bihan, T, Granneman, S & Makovets, S 2015, ' Cell populations can use aneuploidy to survive telomerase insufficiency ', Nature Communications, vol. 6, 8664 . https://doi.org/10.1038/ncomms9664
Nature Communications

Telomerase maintains ends of eukaryotic chromosomes, telomeres. Telomerase loss results in replicative senescence and a switch to recombination-dependent telomere maintenance. Telomerase insufficiency in humans leads to telomere syndromes associated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba1abaa56ea6e0188a1698d387507e40
https://hdl.handle.net/20.500.11820/2942d73a-8268-4594-80dd-3ec82b4819a5

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Anatomy and Dynamics of DNA Replication Fork Movement in Yeast Telomeric Regions

Autor: Elizabeth H. Blackburn, Ira Herskowitz, Svetlana Makovets

Publikováno v: Makovets, S, Herskowitz, I & Blackburn, E H 2004, ' Anatomy and dynamics of DNA replication fork movement in yeast telomeric regions ', Molecular and Cellular Biology, vol. 24, no. 9, pp. 4019-31 . https://doi.org/10.1128/MCB.24.9.4019-4031.2004

Replication of the linear DNA of a eukaryotic chromosome imposes a problem of end replication, as originally predicted by Watson (40) and Olovnikov (31). While the synthesis of the leading strand can proceed to the very end of the template, the laggi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::922d56e5f8ed9f491533ef0bf97e172f
https://doi.org/10.1128/mcb.24.9.4019-4031.2004

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Is modification sufficient to protect a bacterial chromosome from a resident restriction endonuclease?

Autor: Noreen E. Murray, Annette J. B. Titheradge, Svetlana Makovets, T. Lynn M. Powell, Garry W. Blakely

Publikováno v: Molecular Microbiology. 51:135-147

It has been generally accepted that DNA modification protects the chromosome of a bacterium encoding a restriction and modification system. But, when target sequences within the chromosome of one such bacterium (Escherichia coli K-12) are unmodified,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::82ded4883880a40e42a05408db1c705f
https://doi.org/10.1046/j.1365-2958.2003.03801.x

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ClpX and ClpP are essential for the efficient acquisition of genes specifying type IA and IB restriction systems

Autor: Annette J. B. Titheradge, Svetlana Makovets, Noreen E. Murray

Publikováno v: Molecular Microbiology. 28:25-35

Efficient acquisition of genes that encode a restriction and modification (R-M) system with specificities different from any already present in the recipient bacterium requires the sequential production of the new modification enzyme followed by the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::966699fc83fd3d2fa2101f20a9c3c528
https://doi.org/10.1046/j.1365-2958.1998.00767.x

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