Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Svetlana, Gaidarova"'
Autor:
Frank Cichocki, Ryan Bjordahl, Jodie P. Goodridge, Sajid Mahmood, Svetlana Gaidarova, Ramzey Abujarour, Zachary B. Davis, Aimee Merino, Katie Tuininga, Hongbo Wang, Akhilesh Kumar, Brian Groff, Alec Witty, Greg Bonello, Janel Huffman, Thomas Dailey, Tom T. Lee, Karl-Johan Malmberg, Bruce Walcheck, Uta Höpken, Armin Rehm, Bahram Valamehr, Jeffrey S. Miller
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
The use of chimeric antigen receptor modified immune cell therapeutics has improved the treatment of a range of tumours. Here the authors explore a dual-target iPSC-derived NK cell product as a potential therapeutic for the treatment of multiple myel
Externí odkaz:
https://doaj.org/article/cf51e4650f724761987dbfd84d67e91a
Autor:
Tom Lee, John Goulding, Mochtar Pribadi, Robert Blum, Wen-I Yeh, Yijia Pan, Svetlana Gaidarova, Chia-Wei Chang, Hui-Yi Chu, Ellen Liu, Shohreh Sikaroodi, Lucas Ferrari de Andrade, Lauren Fong, Janel Huffman, Ryan Bjordahl, Kai Wucherpfennig, Bahram Valamehr
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)
Externí odkaz:
https://doaj.org/article/dc7d6b71029847c78280719e191b744e
Autor:
Frank Cichocki, Jodie P. Goodridge, Ryan Bjordahl, Sajid Mahmood, Zachary B. Davis, Svetlana Gaidarova, Ramzey Abujarour, Brian Groff, Alec Witty, Hongbo Wang, Katie Tuininga, Behiye Kodal, Martin Felices, Greg Bonello, Janel Huffman, Thomas Dailey, Tom T. Lee, Bruce Walcheck, Bahram Valamehr, Jeffrey S. Miller
Publikováno v:
Blood. 140:2451-2462
Substantial numbers of B cell leukemia and lymphoma patients relapse due to antigen loss or heterogeneity after anti-CD19 chimeric antigen receptor (CAR) T cell therapy. To overcome antigen escape and address antigen heterogeneity, we engineered indu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd0558c4151a2c6e7c41f9b7b653f73c
https://doi.org/10.1182/blood.2021015184
https://doi.org/10.1182/blood.2021015184
Autor:
Jeffrey S. Miller, Sarah Cooley, Scott Wolchko, Bruce R. Blazar, Yenan T. Bryceson, Daniel Shoemaker, Stewart Abbot, Heinrich Schlums, Emily Taras, Dhifaf Sarhan, Peter Howard, Valarie McCullar, Phillip Dougherty, Katie Tuininga, Stacey Moreno, Svetlana Gaidarova, Paul Rogers, Betsy Rezner, Bin Zhang, Ryan Bjordahl, Bahram Valamehr, Frank Cichocki
This supplementary file contains Supplemental Figures 1-6. Supplemental Figure 1 shows that 7-day ex vivo culture of NK cells with IL-15 and 5 μM CHIR99021 leads to an increase in the frequencies of NK cells with heterogeneous adaptive NK cell pheno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::184b0fb84c9ccf8c3dc8884bfbd7510a
https://doi.org/10.1158/0008-5472.22414707
https://doi.org/10.1158/0008-5472.22414707
Autor:
Jeffrey S. Miller, Sarah Cooley, Scott Wolchko, Bruce R. Blazar, Yenan T. Bryceson, Daniel Shoemaker, Stewart Abbot, Heinrich Schlums, Emily Taras, Dhifaf Sarhan, Peter Howard, Valarie McCullar, Phillip Dougherty, Katie Tuininga, Stacey Moreno, Svetlana Gaidarova, Paul Rogers, Betsy Rezner, Bin Zhang, Ryan Bjordahl, Bahram Valamehr, Frank Cichocki
Maturation of human natural killer (NK) cells as defined by accumulation of cell-surface expression of CD57 is associated with increased cytotoxic character and TNF and IFNγ production upon target-cell recognition. Notably, multiple studies point to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::85658b7abe87652af3f076650f779e3e
https://doi.org/10.1158/0008-5472.c.6509055.v1
https://doi.org/10.1158/0008-5472.c.6509055.v1
Autor:
Ya-Ju Chang, Niancao Chen, Christine Chen, Tingxia Guo, Jaslem Herrera Valdez, Svetlana Gaidarova, Bryan Hancock, Betsy Rezner, Yvonne Lentz, Mark Plavsic, Richard Anderson, Raedun Clarke, Bahram Valamehr
Publikováno v:
Blood. 140:4693-4694
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4b94d444f3dbfc36a354976f839d4f3b
https://doi.org/10.1182/blood-2022-162712
https://doi.org/10.1182/blood-2022-162712
Autor:
Svetlana Gaidarova, Hongbo Wang, Frank Cichocki, Jeffrey S. Miller, Bruce Walcheck, Brian Hancock, Miguel Meza, Ryan Bjordahl, Karrune Woan, Bruce R. Blazar, Bahram Valamehr, Janel Huffman, Melissa Khaw, Karl J. Malmberg, Ramzey Abujarour, Hansol Kim, Moyar Q. Ge, Bin Zhang, Thomas Dailey, John Goulding, Martin Felices, Cheng-Ying Wu, Tom Tong Lee, Yenan T. Bryceson, Greg Bonello, Laura Bendzick, Sajid Mahmood, Behiye Kodal, Zachary Davis, Paul Rogers, Katie Tuininga
Publikováno v:
Cell Stem Cell
2062-2075.e5
2062-2075.e5
Select subsets of immune effector cells have the greatest propensity to mediate antitumor responses. However, procuring these subsets is challenging, and cell-based immunotherapy is hampered by limited effector-cell persistence and lack of on-demand
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6766136eac4f6f069666145ff5d870ee
https://hdl.handle.net/11250/2986523
https://hdl.handle.net/11250/2986523
Autor:
Joshua T. Walker, Martin Felices, Frank Cichocki, Ryan Bjordahl, Bahram Valamehr, Jeffrey S. Miller, Alexander J. Lenvik, Daniel A. Vallera, Zachary Davis, Nicholas A. Zorko, Todd Lenvik, Alejandro Garcia, Thomas H. Lee, Behiye Kodal, Svetlana Gaidarova
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)
Background B7H3 is a tumor associated antigen (TAA), found on numerous malignancies including prostate, lung, and breast cancers. High levels of B7H3 expression are correlated with late stage disease and poor prognosis. Furthermore, B7H3 is minimally
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4d067c8a4c62c532973385644ee9c1e
https://doaj.org/article/51f8f192256a47a3a73266200f93f317
https://doaj.org/article/51f8f192256a47a3a73266200f93f317
Autor:
Frank Cichocki, Martin Felices, Svetlana Gaidarova, Ryan Bjordahl, Bahram Valamehr, David Robbins, Laurel Stokely, Jeffrey S. Miller, Betsy Rezner, Hongbo Wang, Bruce R. Blazar, Moyar Q. Ge, Raedun Clarke, Ramzey Abujarour, Laura Bendzick, Megan Robinson, Tom Tong Lee, Zachary Davis, Paul Rogers, Dan S. Kaufman, Katie Tuininga, Sajid Mahmood
Publikováno v:
Science translational medicine, vol 12, iss 568
Sci Transl Med
Sci Transl Med
The development of immunotherapeutic monoclonal antibodies targeting checkpoint inhibitory receptors, such as programmed cell death 1 (PD-1), or their ligands, such as PD-L1, has transformed the oncology landscape. However, durable tumor regression i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e726ff274f3666a5b1b2356c5862ef50
https://escholarship.org/uc/item/6s79g6hx
https://escholarship.org/uc/item/6s79g6hx
Autor:
Jianming Wu, Ramzey Abujarour, Pei Fang Tsai, Dan S. Kaufman, Svetlana Gaidarova, Robert Blum, Gregory B. Bonello, Bruce Walcheck, Bahram Valamehr, Paul Rogers, Ryan Bjordahl, Huang Zhu, Jeffrey S. Miller, Tom Tong Lee
Publikováno v:
Blood
Blood, vol 135, iss 6
Blood, vol 135, iss 6
Antibody-dependent cellular cytotoxicity (ADCC) is a key effector mechanism of natural killer (NK) cells that is mediated by therapeutic monoclonal antibodies (mAbs). This process is facilitated by the Fc receptor CD16a on human NK cells. CD16a appea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1702557d18ffceeec8d54e7814665a92
https://europepmc.org/articles/PMC7005364/
https://europepmc.org/articles/PMC7005364/