Selection of O-negative induced pluripotent stem cell clones for high-density red blood cell production in a scalable perfusion bioreactor system

Autor: SuE Yu, Svetlan Vassilev, Zhong Ri Lim, Jaichandran Sivalingam, Alan Tin Lun Lam, Valerie Ho, Laurent Renia, Benoit Malleret, Shaul Reuveny, Steve Kah Weng Oh

Publikováno v: Cell proliferation. 55(8)

Large-scale generation of universal red blood cells (RBCs) from O-negative (O-ve) human induced pluripotent stem cells (hiPSCs) holds the potential to alleviate worldwide shortages of blood and provide a safe and secure year-round supply. Mature RBCs

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::766d7f9836acee3ae050912a3af72c9d
https://pubmed.ncbi.nlm.nih.gov/35289971

Industrially Compatible Transfusable iPSC-Derived RBCs: Progress, Challenges and Prospective Solutions

Autor: Svetlan Vassilev, Jing Wen Hang, Zhong Ri Lim, Laurent Rénia, Benoit Malleret, Yew Wai Leong, Steve Oh

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 9808, p 9808 (2021)

Amidst the global shortfalls in blood supply, storage limitations of donor blood and the availability of potential blood substitutes for transfusion applications, society has pivoted towards in vitro generation of red blood cells (RBCs) as a means to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1eba223272d0f211dd140cef79aee9e
https://doi.org/10.3390/ijms22189808