Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Sverre E. Aune"'
Autor:
Lauren E. Ball, Daniel J. Herr, James C. Chou, Mauhamad Baarine, John J. Lemasters, Craig Beeson, Sverre E. Aune, Donald R. Menick, Xiaoyang Li
Publikováno v:
Journal of Molecular and Cellular Cardiology. 114:309-319
Rationale Recent evidence indicates that histone deacetylase enzymes (HDACs) contribute to ischemia reperfusion (I/R) injury, and pan-HDAC inhibitors have been shown to be cardioprotective when administered either before an ischemic insult or during
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97c88e31808fca3aad736ff870007dd7
https://doi.org/10.1016/j.yjmcc.2017.12.004
https://doi.org/10.1016/j.yjmcc.2017.12.004
Publikováno v:
Circulation Research. 119
Although rapid reperfusion of ischemic tissue is the treatment of choice for myocardial infarction, a significant amount of damage occurs as a result of reperfusion itself. The role of epigenetic enzymes in modulating this damage has become an area o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::84ddef7489aff37404d7752ffc064ec6
https://doi.org/10.1161/res.119.suppl_1.443
https://doi.org/10.1161/res.119.suppl_1.443
Publikováno v:
Resuscitation. 82:S48-S51
Introduction Rapid post-ischemic re-oxygenation is necessary to minimize ischemic injury, but itself can induce further reperfusion injury through the induction of reactive oxygen species. Utilization of oxygen within the cell primarily occurs in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36021140c5024be5f3233294cd9adafe
https://doi.org/10.1016/s0300-9572(11)70151-4
https://doi.org/10.1016/s0300-9572(11)70151-4
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 292:H109-H116
Reperfusion of the ischemic myocardium leads to a burst of reactive O2species (ROS), which is a primary determinant of postischemic myocardial dysfunction. We tested the hypothesis that early O2delivery and the cellular redox state modulate the initi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfe59abf354cedd7153d74a9e1bb9381
https://doi.org/10.1152/ajpheart.00925.2006
https://doi.org/10.1152/ajpheart.00925.2006
The biochemical events surrounding ischemia reperfusion injury in the acute setting are of great importance to furthering novel treatment options for myocardial infarction and cardiac complications of thoracic surgery. The ability of certain drugs to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aabefcd65a064e06431ece2f28ea45d6
https://europepmc.org/articles/PMC4544760/
https://europepmc.org/articles/PMC4544760/
Publikováno v:
Circulation Research. 117
Although rapid reperfusion of ischemic tissue is the treatment of choice for myocardial infarction, much of the resultant damage occurs as a consequence of reperfusion itself. Previously, we have shown that pretreatment with MS-275, a selective class
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8baadbd34548da07221de6261530d099
https://doi.org/10.1161/res.117.suppl_1.405
https://doi.org/10.1161/res.117.suppl_1.405
Publikováno v:
Frontiers in Neurology
Frontiers in Neurology, Vol 6 (2015)
Frontiers in Neurology, Vol 6 (2015)
Ischemia-reperfusion (IR) injury comprises a significant portion of morbidity and mortality from heart and brain diseases worldwide. This enduring clinical problem has inspired myriad reports in the scientific literature of experimental interventions
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::149f67425135560d49bc8d52f979a7d2
http://europepmc.org/articles/PMC4485035
http://europepmc.org/articles/PMC4485035
Publikováno v:
Circulation Research. 115
Background: Histone deacetylase (HDAC) enzymes inhibit gene expression through chromatin compaction and exacerbate myocyte death following ischemia-reperfusion (IR) in the heart. In our prior study, disinhibition of antioxidant gene and protein expre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::db877d6368e3ef7b8c9d77b9a7a7f3c0
https://doi.org/10.1161/res.115.suppl_1.363
https://doi.org/10.1161/res.115.suppl_1.363
article i nfo While inhibition of class I/IIb histone deacetylases (HDACs) protects the mammalian heart from ischemia reper- fusion (IR) injury, class selective effects remain unexamined. We hypothesized that selective inhibition of class I HDACs wou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57bbc98a63765f2031cf611e353c762e
https://europepmc.org/articles/PMC4046340/
https://europepmc.org/articles/PMC4046340/
Publikováno v:
Circulation Research. 113
Background: While dual inhibition of class I/IIb KDACs protects the mammalian heart from ischemia-reperfusion (IR) injury, class-specific effects have not been examined. Hypothesis: We hypothesized that specific inhibition of class I KDACs would pres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b2bdb76b7b328d9ba1286860439c8acd
https://doi.org/10.1161/res.113.suppl_1.a222
https://doi.org/10.1161/res.113.suppl_1.a222