Zobrazeno 1 - 10
of 186
pro vyhledávání: '"Sverker Jern"'
Publikováno v:
Research and Practice in Thrombosis and Haemostasis, Vol 6, Iss 4, Pp n/a-n/a (2022)
Abstract Background Knowledge on differences in patients who present with deep vein thrombosis (DVT) and those with pulmonary embolism (PE) is incomplete. Objective To determine comorbidities and temporary provoking factors in patients with a first
Externí odkaz:
https://doaj.org/article/b9e88cb2cde04188bbc3757bb1335eb7
Autor:
Karin Mossberg, Josefin Olausson, Emanuel Fryk, Sverker Jern, Per-Anders Jansson, Helén Brogren
Publikováno v:
PLoS ONE, Vol 17, Iss 8, p e0267833 (2022)
BackgroundThe main inhibitor of the fibrinolytic system, Plasminogen Activator Inhibitor -1 (PAI-1), irreversibly binds tissue-type Plasminogen Activator (t-PA) and thereby inhibits the protective action of tPA against thrombus formation. Elevated le
Externí odkaz:
https://doaj.org/article/7d9b5e5824df456a98c4c8c5db8dbe54
Publikováno v:
International Journal of Vascular Medicine, Vol 2016 (2016)
Objective. Endothelial tissue-type plasminogen activator (t-PA) release is a pivotal response to protect the circulation from occluding thrombosis. We have shown that the t-PA gene is epigenetically regulated and greatly induced by the histone deacet
Externí odkaz:
https://doaj.org/article/16b5854a967449539b07e055a5e4b269
Autor:
Kristina Svennerholm, Michael Haney, Björn Biber, Erik Ulfhammer, Ott Saluveer, Pia Larsson, Elmir Omerovic, Sverker Jern, Niklas Bergh
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0128283 (2015)
Externí odkaz:
https://doaj.org/article/f2480fa4634247138fdb97a2f50ee931
Autor:
Mia Magnusson, Emma Xuchun Lu, Pia Larsson, Erik Ulfhammer, Niklas Bergh, Helena Carén, Sverker Jern
Publikováno v:
PLoS ONE, Vol 10, Iss 10, p e0141805 (2015)
Tissue-type plasminogen activator (t-PA), which is synthesized in the endothelial cells lining the blood vessel walls, is a key player in the fibrinolytic system protecting the circulation against occluding thrombus formation. Although classical gene
Externí odkaz:
https://doaj.org/article/166a4e10d025427590e1ba70a8675d2e
Autor:
Kristina Svennerholm, Michael Haney, Björn Biber, Erik Ulfhammer, Ott Saluveer, Pia Larsson, Elmir Omerovic, Sverker Jern, Niklas Bergh
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0121196 (2015)
The expression of the tissue plasminogen activator (t-PA) gene appears to be under epigenetic control and can be affected by histone deacetylation inhibition. The study aimed to test if histone deacetalyase inhibitor treatment lead to increased t-PA
Externí odkaz:
https://doaj.org/article/381664977cd84508822470fc568d998c
Autor:
Ott Saluveer, Pia Larsson, Wilhelm Ridderstråle, Thórdís J Hrafnkelsdóttir, Sverker Jern, Niklas Bergh
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e107582 (2014)
AIMS: The aim of the study was to test if pharmacological intervention by valproic acid (VPA) treatment can modulate the fibrinolytic system in man, by means of increased acute release capacity of tissue plasminogen activator (t-PA) as well as an alt
Externí odkaz:
https://doaj.org/article/ada22bdc6d11401c8664f55e50a90e3c
Histone deacetylase inhibitor treatment increases coronary t-PA release in a porcine ischemia model.
Autor:
Kristina Svennerholm, Niklas Bergh, Pia Larsson, Sverker Jern, Göran Johansson, Björn Biber, Michael Haney
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e97260 (2014)
BACKGROUND: The expression of the tissue plasminogen activator gene can be affected by histone deacetylation inhibition and thus appears to be under epigenetic control. OBJECTIVES: The study aimed to test if in vivo pharmacological intervention by va
Externí odkaz:
https://doaj.org/article/55fa8defde7542beb98a0eb8b2859f14
Autor:
Pia Larsson, Erik Ulfhammer, Mia Magnusson, Niklas Bergh, Sebastian Lunke, Assam El-Osta, Robert L Medcalf, Per-Arne Svensson, Lena Karlsson, Sverker Jern
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e31573 (2012)
AIMS: Stimulated release of tissue-type plasminogen activator (t-PA) is pivotal for an intravascular fibrinolytic response and protects the circulation from occluding thrombosis. Hence, an impaired t-PA production is associated with increased risk fo
Externí odkaz:
https://doaj.org/article/da97fee7b5fe4e688af01ef94d47a7bb
Publikováno v:
PLoS ONE, Vol 6, Iss 11, p e26762 (2011)
The vascular fibrinolytic system is crucial for spontaneous lysis of blood clots. Plasminogen activator inhibitor 1 (PAI-1), the principal inhibitor of the key fibrinolytic enzyme tissue-type plasminogen activator (tPA), is present in platelets at hi
Externí odkaz:
https://doaj.org/article/68aff3c9466e4b9ea472f4eb79e09e87