Cryptosporidium lysyl-tRNA synthetase inhibitors define the interplay between solubility and permeability required to achieve efficacy.

Autor: Caldwell N; Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK., Peet C; Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK., Miller P; Department of Medicine, University of Vermont, Larner College of Medicine, Burlington, VT 05401, USA., Colon BL; Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK., Taylor MG; Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK., Cocco M; Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK., Dawson A; Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK., Lukac I; Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK., Teixeira JE; Department of Medicine, University of Vermont, Larner College of Medicine, Burlington, VT 05401, USA., Robinson L; Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK., Frame L; Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK., Seizova S; Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK., Damerow S; Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK., Tamaki F; Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK., Post J; Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK., Riley J; Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK., Mutter N; Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK., Hanna JC; Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK., Ferguson L; Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK., Hu X; Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK., Tinti M; Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK., Forte B; Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK., Norcross NR; Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK., Campbell PS; Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK., Svensen N; Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK., Caldwell FC; Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK., Jansen C; Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK., Postis V; Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK., Read KD; Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK., Huston CD; Department of Medicine, University of Vermont, Larner College of Medicine, Burlington, VT 05401, USA., Gilbert IH; Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK., Baragaña B; Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK., Pawlowic MC; Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK.

Publikováno v: Science translational medicine [Sci Transl Med] 2024 Oct 23; Vol. 16 (770), pp. eadm8631. Date of Electronic Publication: 2024 Oct 23.

Self-Assembly of Intracellular Multivalent RNA Complexes Using Dimeric Corn and Beetroot Aptamers.

Autor: Wu J; Department of Pharmacology, Weill Cornell Medicine, Cornell University, New York, New York 10065, United States., Svensen N; Department of Pharmacology, Weill Cornell Medicine, Cornell University, New York, New York 10065, United States., Song W; Department of Pharmacology, Weill Cornell Medicine, Cornell University, New York, New York 10065, United States., Kim H; Department of Pharmacology, Weill Cornell Medicine, Cornell University, New York, New York 10065, United States., Zhang S; Beijing Institutes of Life Science, Chinese Academy of Sciences, Beijing 100101, P. R. China., Li X; Beijing Institutes of Life Science, Chinese Academy of Sciences, Beijing 100101, P. R. China., Jaffrey SR; Department of Pharmacology, Weill Cornell Medicine, Cornell University, New York, New York 10065, United States.

Publikováno v: Journal of the American Chemical Society [J Am Chem Soc] 2022 Mar 30; Vol. 144 (12), pp. 5471-5477. Date of Electronic Publication: 2022 Mar 16.

Developing 1,4-Diethyl-1,2,3,4-tetrahydroquinoxalin-substituted Fluorogens Based on GFP Chromophore for Endoplasmic Reticulum and Lysosome Staining.

Autor: Rudik, Daniil I.^1,2 (AUTHOR) rudikdany@gmail.com, Perfilov, Maxim M.¹ (AUTHOR), Sokolov, Anatolii I.^1,3 (AUTHOR), Chen, Cheng⁴ (AUTHOR) chong.fang@oregonstate.edu, Baleeva, Nadezhda S.^1,3 (AUTHOR), Myasnyanko, Ivan N.^1,3 (AUTHOR), Mishin, Alexander S.¹ (AUTHOR), Fang, Chong⁴ (AUTHOR), Bogdanova, Yulia A.^1,3 (AUTHOR) yuliabogdanova@ibch.ru, Baranov, Mikhail S.^1,3 (AUTHOR)

Publikováno v: International Journal of Molecular Sciences. Oct2024, Vol. 25 Issue 19, p10448. 19p.

Imaging the dynamics of messenger RNA with a bright and stable green fluorescent RNA.

Autor: Zuo F; Optogenetics & Synthetic Biology Interdisciplinary Research Center, State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, China.; Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, School of Pharmacy, East China University of Science and Technology, Shanghai, China., Jiang L; School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China., Su N; Optogenetics & Synthetic Biology Interdisciplinary Research Center, State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, China.; Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, School of Pharmacy, East China University of Science and Technology, Shanghai, China., Zhang Y; Optogenetics & Synthetic Biology Interdisciplinary Research Center, State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, China.; Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, School of Pharmacy, East China University of Science and Technology, Shanghai, China., Bao B; School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China., Wang L; Optogenetics & Synthetic Biology Interdisciplinary Research Center, State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, China.; Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, School of Pharmacy, East China University of Science and Technology, Shanghai, China., Shi Y; Optogenetics & Synthetic Biology Interdisciplinary Research Center, State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, China., Yang H; Optogenetics & Synthetic Biology Interdisciplinary Research Center, State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, China.; Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, School of Pharmacy, East China University of Science and Technology, Shanghai, China., Huang X; School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China., Li R; Optogenetics & Synthetic Biology Interdisciplinary Research Center, State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, China., Zeng Q; School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China., Chen Z; Optogenetics & Synthetic Biology Interdisciplinary Research Center, State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, China.; Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, School of Pharmacy, East China University of Science and Technology, Shanghai, China., Lin Q; School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China., Zhuang Y; School of Bioengineering, East China University of Science and Technology, Shanghai, China., Zhao Y; Optogenetics & Synthetic Biology Interdisciplinary Research Center, State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, China.; Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, School of Pharmacy, East China University of Science and Technology, Shanghai, China.; Research Unit of New Techniques for Live-cell Metabolic Imaging, Chinese Academy of Medical Sciences, Beijing, China., Chen X; Optogenetics & Synthetic Biology Interdisciplinary Research Center, State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, China. xianjunchen@ecust.edu.cn.; Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, School of Pharmacy, East China University of Science and Technology, Shanghai, China. xianjunchen@ecust.edu.cn.; Research Unit of New Techniques for Live-cell Metabolic Imaging, Chinese Academy of Medical Sciences, Beijing, China. xianjunchen@ecust.edu.cn., Zhu L; Optogenetics & Synthetic Biology Interdisciplinary Research Center, State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, China. linyongzhu@sjtu.edu.cn.; School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China. linyongzhu@sjtu.edu.cn., Yang Y; Optogenetics & Synthetic Biology Interdisciplinary Research Center, State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, China. yiyang@ecust.edu.cn.; Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, School of Pharmacy, East China University of Science and Technology, Shanghai, China. yiyang@ecust.edu.cn.

Publikováno v: Nature chemical biology [Nat Chem Biol] 2024 Oct; Vol. 20 (10), pp. 1272-1281. Date of Electronic Publication: 2024 May 23.

Broccoli aptamer allows quantitative transcription regulation studies in vitro.

Autor: van der Sijs, Amanda¹ (AUTHOR), Visser, Thomas¹ (AUTHOR), Moerman, Pepijn² (AUTHOR), Folkers, Gert³ (AUTHOR), Kegel, Willem¹ (AUTHOR) w.k.kegel@uu.nl

Publikováno v: PLoS ONE. 6/13/2024, Vol. 19 Issue 6, p1-15. 15p.