Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Svenja Wiechmann"'
Autor:
Andreas Ernst, Andreas Weigert, Priscila da Silva, Javier Mora, Xin You, Svenja Wiechmann, Mateusz Putyrski, Javier Garcia-Pardo, Aimo Kannt, Bernhard Bruene
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 12, Iss 8 (2024)
Background The interleukin (IL)-1-family receptor antagonist IL-38 has emerged as a negative regulator of auto-inflammation. Given the intricate interplay between antitumor immunity and auto-inflammation, we hypothesized that blocking IL-38 may enhan
Externí odkaz:
https://doaj.org/article/6ab5abd72d6643518a19bf5844b185f5
Stress-primed secretory autophagy promotes extracellular BDNF maturation by enhancing MMP9 secretion
Autor:
Silvia Martinelli, Elmira A. Anderzhanova, Thomas Bajaj, Svenja Wiechmann, Frederik Dethloff, Katja Weckmann, Daniel E. Heinz, Tim Ebert, Jakob Hartmann, Thomas M. Geiger, Michael Döngi, Kathrin Hafner, Max L. Pöhlmann, Lee Jollans, Alexandra Philipsen, Susanne V. Schmidt, Ulrike Schmidt, Giuseppina Maccarrone, Valentin Stein, Felix Hausch, Christoph W. Turck, Mathias V. Schmidt, Anne-Kathrin Gellner, Bernhard Kuster, Nils C. Gassen
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Glucocorticoids are associated with stress. Here, the authors show that high levels of glucocorticoid stress promote secretory autophagy of matrix metalloproteinase 9 via a stress responsive chaperone, increasing brain-derived neurotrophic factor pro
Externí odkaz:
https://doaj.org/article/4b82f8ddb5c141baac1137b7deee6057
Autor:
Vanessa Dietinger, Cira R. García de Durango, Svenja Wiechmann, Sophie L. Boos, Marlies Michl, Jens Neumann, Heiko Hermeking, Bernhard Kuster, Peter Jung
Publikováno v:
Cell Communication and Signaling, Vol 18, Iss 1, Pp 1-24 (2020)
Abstract Background Wnt signaling drives epithelial self-renewal and disease progression in human colonic epithelium and colorectal cancer (CRC). Characterization of Wnt effector pathways is key for our understanding of these processes and for develo
Externí odkaz:
https://doaj.org/article/fd5a7a6483cd4180b87e3763382c2da5
Autor:
Yangyang Bian, Runsheng Zheng, Florian P. Bayer, Cassandra Wong, Yun-Chien Chang, Chen Meng, Daniel P. Zolg, Maria Reinecke, Jana Zecha, Svenja Wiechmann, Stephanie Heinzlmeir, Johannes Scherr, Bernhard Hemmer, Mike Baynham, Anne-Claude Gingras, Oleksandr Boychenko, Bernhard Kuster
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Mass spectrometry-based proteomics typically relies on highly sensitive nano-flow liquid chromatography (LC) but this can reduce robustness and reproducibility. Here, the authors show that micro-flow LC enables robust and reproducible high-throughput
Externí odkaz:
https://doaj.org/article/51978dfc79c64bbfbbf6af243fbb23c2
Autor:
Yingying Han, Javier Mora, Arnaud Huard, Priscila da Silva, Svenja Wiechmann, Mateusz Putyrski, Christian Schuster, Eiman Elwakeel, Guangping Lang, Anica Scholz, Tatjana Scholz, Tobias Schmid, Natasja de Bruin, Pierre Billuart, Carlo Sala, Harald Burkhardt, Michael J. Parnham, Andreas Ernst, Bernhard Brüne, Andreas Weigert
Publikováno v:
Cell Reports, Vol 27, Iss 3, Pp 835-846.e5 (2019)
Summary: Interleukin-38 (IL-38) is a cytokine of the IL-1 family with a role in chronic inflammation. However, its main cellular targets and receptors remain obscure. IL-38 is highly expressed in the skin and downregulated in psoriasis patients. We r
Externí odkaz:
https://doaj.org/article/6b0ea48022dd45428022b5ac6a3fd6d3
Autor:
Martin Wegner, Valentina Diehl, Verena Bittl, Rahel de Bruyn, Svenja Wiechmann, Yves Matthess, Marie Hebel, Michael GB Hayes, Simone Schaubeck, Christopher Benner, Sven Heinz, Anja Bremm, Ivan Dikic, Andreas Ernst, Manuel Kaulich
Publikováno v:
eLife, Vol 8 (2019)
Current technologies used to generate CRISPR/Cas gene perturbation reagents are labor intense and require multiple ligation and cloning steps. Furthermore, increasing gRNA sequence diversity negatively affects gRNA distribution, leading to libraries
Externí odkaz:
https://doaj.org/article/393c8588725544a5ab186bfe7246d237
Autor:
Jana Zecha, Florian P. Bayer, Svenja Wiechmann, Julia Woortman, Nicola Berner, Julian Müller, Annika Schneider, Karl Kramer, Mar Abril-Gil, Thomas Hopf, Leonie Reichart, Lin Chen, Fynn M. Hansen, Severin Lechner, Patroklos Samaras, Stephan Eckert, Ludwig Lautenbacher, Maria Reinecke, Firas Hamood, Polina Prokofeva, Larsen Vornholz, Chiara Falcomatà, Madeleine Dorsch, Ayla Schröder, Anton Venhuizen, Stephanie Wilhelm, Guillaume Médard, Gabriele Stoehr, Jürgen Ruland, Barbara M. Grüner, Dieter Saur, Maike Buchner, Benjamin Ruprecht, Hannes Hahne, Matthew The, Mathias Wilhelm, Bernhard Kuster
Although most cancer drugs modulate the activities of cellular pathways by changing posttranslational modifications (PTMs), little is known regarding the extent and the time- and dose-response characteristics of drug-regulated PTMs. In this work, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c87d1d00a70e16be3fa10729e9a3ae2
https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&origin=inward&scp=85152012772
https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&origin=inward&scp=85152012772
Autor:
Svenja Wiechmann, Tufan Gökirmak, Punit P. Seth, Michael Tanowitz, Mehran Nikan, Thazha P. Prakash
Publikováno v:
Trends in Pharmacological Sciences. 42:588-604
Synthetic therapeutic oligonucleotides (STO) represent the third bonafide platform for drug discovery in the pharmaceutical industry after small molecule and protein therapeutics. So far, thirteen STOs have been approved by regulatory agencies and ov
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71e54fe9b4b34052e40f0a3021ef9698
https://doi.org/10.1016/j.tips.2021.04.010
https://doi.org/10.1016/j.tips.2021.04.010
Autor:
Jens, Stepan, Daniel E, Heinz, Frederik, Dethloff, Thomas, Bajaj, Andreas, Zellner, Kathrin, Hafner, Svenja, Wiechmann, Sarah, Mackert, Yara, Mecdad, Michael, Rabenstein, Tim, Ebert, Silvia, Martinelli, Alexander S, Häusl, Maximilian L, Pöhlmann, Anke, Hermann, Xiao, Ma, Hermann, Pavenstädt, Mathias V, Schmidt, Alexandra, Philipsen, Chris W, Turck, Jan M, Deussing, Bernhard, Kuster, Michael C, Wehr, Valentin, Stein, Joachim, Kremerskothen, Carsten T, Wotjak, Nils C, Gassen
Publikováno v:
Cell reports. 41(10)
Learning and memory rely on changes in postsynaptic glutamergic α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type receptor (AMPAR) number, spatial organization, and function. The Hippo pathway component WW and C2 domain-containing pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::de9fdfa687008404386b679469d8a8ac
https://pubmed.ncbi.nlm.nih.gov/36476872
https://pubmed.ncbi.nlm.nih.gov/36476872
Autor:
Svenja Wiechmann, Anne-Claude Gingras, Yun-Chien Chang, Runsheng Zheng, Maria Reinecke, Yangyang Bian, Mike Baynham, Florian P. Bayer, Chen Meng, Bernhard Hemmer, Cassandra J. Wong, Jana Zecha, Daniel P Zolg, Stephanie Heinzlmeir, Bernhard Kuster, Johannes Scherr, Oleksandr Boychenko
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Nature communications
Nature Communications
Nature communications
Nature Communications
Nano-flow liquid chromatography tandem mass spectrometry (nano-flow LC–MS/MS) is the mainstay in proteome research because of its excellent sensitivity but often comes at the expense of robustness. Here we show that micro-flow LC–MS/MS using a 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64d930414299e72afffdf9dc9159bde9
https://doaj.org/article/51978dfc79c64bbfbbf6af243fbb23c2
https://doaj.org/article/51978dfc79c64bbfbbf6af243fbb23c2