Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Svenja V, Trossbach"'
Autor:
Mohammad Seidisarouei, Sandra Schäble, Marijn van Wingerden, Svenja V. Trossbach, Carsten Korth, Tobias Kalenscher
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Deficits in social interaction or social cognition are key phenotypes in a variety of chronic mental diseases, yet, their modeling and molecular dissection are only in their infancy. The Disrupted-in-Schizophrenia 1 (DISC1) signaling pathway
Externí odkaz:
https://doaj.org/article/59b321a8206a4d1c82ba472db7514020
Autor:
Mohammad Seidisarouei, Sandra Schäble, Marijn vanWingerden, Svenja V. Trossbach, Carsten Korth, Tobias Kalenscher
Publikováno v:
Brain and Behavior, Vol 13, Iss 5, Pp n/a-n/a (2023)
Abstract Patients diagnosed with neuropsychiatric disorders, such as autism and schizophrenia, suffer from disorganized speech. The disrupted‐in‐schizophrenia 1 (DISC1) protein pathway is considered a risk factor for the development of several ps
Externí odkaz:
https://doaj.org/article/f596c037417d44ba8ef35ed868d35cb9
Autor:
An-Li, Wang, Owen Y, Chao, Susanne, Nikolaus, Valeria, Lamounier-Zepter, Cornelis P, Hollenberg, Gert, Lubec, Svenja V, Trossbach, Carsten, Korth, Joseph P, Huston
Publikováno v:
Neuroscience. 493:41-51
Alterations in cognitive functions, social behaviors and stress reactions are commonly diagnosed in chronic mental illnesses (CMI). Animal models expressing mutant genes associated to CMI represent either rare mutations or those contributing only min
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5630d29a5b8fb501964beef91d1c2f93
https://doi.org/10.1016/j.neuroscience.2022.04.013
https://doi.org/10.1016/j.neuroscience.2022.04.013
Autor:
null Mohammad Seidisarouei, null Sandra Schäble, null Marijn van Wingerden, null Svenja V. Trossbach, null Carsten Korth, null Tobias Kalenscher
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9f6e73fb98017b959520f19bc52e71d3
https://doi.org/10.1002/brb3.2984/v2/response1
https://doi.org/10.1002/brb3.2984/v2/response1
Autor:
Fernando J. Sialana, An-Li Wang, Benedetta Fazari, Martina Kristofova, Roman Smidak, Svenja V. Trossbach, Carsten Korth, Joseph P. Huston, Maria A. de Souza Silva, Gert Lubec
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 11 (2018)
Disrupted-in-schizophrenia 1 (DISC1) is a key protein involved in behavioral processes and various mental disorders, including schizophrenia and major depression. A transgenic rat overexpressing non-mutant human DISC1, modeling aberrant proteostasis
Externí odkaz:
https://doaj.org/article/c5a986ab4010481a8df67226d7f0f90a
Autor:
Antony S K Yerabham, Andreas Müller-Schiffmann, Tamar Ziehm, Andreas Stadler, Sabrina Köber, Xela Indurkhya, Rita Marreiros, Svenja V Trossbach, Nicholas J Bradshaw, Ingrid Prikulis, Dieter Willbold, Oliver H Weiergräber, Carsten Korth
Publikováno v:
PLoS ONE, Vol 13, Iss 1, p e0191162 (2018)
Accumulating evidence suggests an important role for the Disrupted-in-Schizophrenia 1 (DISC1) protein in neurodevelopment and chronic mental illness. In particular, the C-terminal 300 amino acids of DISC1 have been found to mediate important protein-
Externí odkaz:
https://doaj.org/article/9a019ce9669146ad935d7d90240306aa
Publikováno v:
Trends in Neurosciences. 44:352-365
The ability of viruses to evolve several orders of magnitude faster than their host cells has enabled them to exploit host cellular machinery by selectively recruiting multiprotein complexes (MPCs) for their catalyzed assembly and replication. This h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4e12f25720afbe1b4fea2b2cc96c826
https://doi.org/10.1016/j.tins.2020.11.004
https://doi.org/10.1016/j.tins.2020.11.004
Autor:
Svenja V. Trossbach, Shriya Sahu, Suganya Selvarajah, Andreas Müller-Schiffmann, Ana Raquel Moreira, Vishwanath R. Lingappa, Irina Soloviev, Ingrid Prikulis, Sebastian Hänsch, Carsten Korth, Rita Marreiros, Stefanie Weidtkamp-Peters
Publikováno v:
Proc Natl Acad Sci U S A
Neurodegenerative diseases feature specific misfolded or misassembled proteins associated with neurotoxicity. The precise mechanisms by which protein aggregates first arise in the majority of sporadic cases have remained unclear. Likely, a first crit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fd30bc3cd73993fef525fd5bb342087
https://doi.org/10.1073/pnas.1906466117
https://doi.org/10.1073/pnas.1906466117
Autor:
Svenja V. Trossbach, Claudia Mattern, Carsten Korth, Maria A. de Souza Silva, Joseph P. Huston, An-Li Wang, Fernando J. Sialana, Benedetta Fazari, Susanne Nikolaus, Owen Y. Chao, Gert Lubec
Publikováno v:
Experts@Minnesota
The Disrupted-in-Schizophrenia 1 (DISC1) gene has been associated with mental illnesses such as major depression and schizophrenia. The transgenic DISC1 (tgDISC1) rat, which overexpresses the human DISC1 gene, is known to exhibit deficient dopamine (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76a8caa16441e6fa855e08614535bc43
https://doi.org/10.1016/j.nlm.2017.10.015
https://doi.org/10.1016/j.nlm.2017.10.015
Autor:
Karola Kaefer, Joseph O'Neill, Hugo Malagon-Vina, Carsten Korth, Svenja V. Trossbach, Jozsef Csicsvari, Desiree D. Dickerson
Publikováno v:
Hippocampus
Aberrant proteostasis of protein aggregation may lead to behavior disorders including chronic mental illnesses (CMI). Furthermore, the neuronal activity alterations that underlie CMI are not well understood. We recorded the local field potential and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c655df37cf82a26c3e1bfe6101d8c929