Identification and Quantification of (t)RNA Modifications in Pseudomonas aeruginosa by Liquid Chromatography-Tandem Mass Spectrometry

Autor: Kevin Ferreira, Sebastian Doberenz, Susanne Häussler, Jonas Krueger, Svenja Grobe, Volkhard Kaever, Mark Brönstrup

Publikováno v: Chembiochem : a European journal of chemical biology

Transfer RNA (tRNA) modifications impact the structure and function of tRNAs, thus affecting the efficiency and fidelity of translation. In the opportunistic pathogen Pseudomonas aeruginosa translational regulation plays an important but less defined

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fb5b240bfa1a9909308d3a38b169e6c
https://pubmed.ncbi.nlm.nih.gov/30644616

Characterization of BNT162b2 mRNA to Evaluate Risk of Off-Target Antigen Translation.

Autor: Patel HK; Analytical Research and Development, Biotherapeutics Pharmaceutical Sciences, Pfizer Inc., Andover, MA 01810, USA., Zhang K; Analytical Research and Development, Biotherapeutics Pharmaceutical Sciences, Pfizer Inc., Chesterfield, MO 63017, USA., Utegg R; Analytical Research and Development, Biotherapeutics Pharmaceutical Sciences, Pfizer Inc., Andover, MA 01810, USA., Stephens E; Analytical Research and Development, Biotherapeutics Pharmaceutical Sciences, Pfizer Inc., Andover, MA 01810, USA., Salem S; Analytical Research and Development, Biotherapeutics Pharmaceutical Sciences, Pfizer Inc., Andover, MA 01810, USA., Welch H; Analytical Research and Development, Biotherapeutics Pharmaceutical Sciences, Pfizer Inc., Andover, MA 01810, USA., Grobe S; BioNTech SE, 55131 Mainz, Germany., Schlereth J; BioNTech SE, 55131 Mainz, Germany., Kuhn AN; BioNTech SE, 55131 Mainz, Germany., Ryczek J; Analytical Research and Development, Biotherapeutics Pharmaceutical Sciences, Pfizer Inc., Chesterfield, MO 63017, USA., Cirelli DJ; Analytical Research and Development, Biotherapeutics Pharmaceutical Sciences, Pfizer Inc., Andover, MA 01810, USA., Lerch TF; Analytical Research and Development, Biotherapeutics Pharmaceutical Sciences, Pfizer Inc., Chesterfield, MO 63017, USA. Electronic address: thomas.lerch@pfizer.com.

Publikováno v: Journal of pharmaceutical sciences [J Pharm Sci] 2023 May; Vol. 112 (5), pp. 1364-1371. Date of Electronic Publication: 2023 Jan 13.