Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Svenja, Adrian"'
Autor:
Felicitas Bossler, Bianca J. Kuhn, Thomas Günther, Stephen J. Kraemer, Prajakta Khalkar, Svenja Adrian, Claudia Lohrey, Angela Holzer, Mitsugu Shimobayashi, Matthias Dürst, Arnulf Mayer, Frank Rösl, Adam Grundhoff, Jeroen Krijgsveld, Karin Hoppe-Seyler, Felix Hoppe-Seyler
Publikováno v:
mBio, Vol 10, Iss 1 (2019)
ABSTRACT Hypoxia is linked to therapeutic resistance and poor clinical prognosis for many tumor entities, including human papillomavirus (HPV)-positive cancers. Notably, HPV-positive cancer cells can induce a dormant state under hypoxia, characterize
Externí odkaz:
https://doaj.org/article/918e7614f6584952bcd19da40a198aa4
Autor:
Egbert F Smit, Christophe Dooms, Jo Raskin, Ernest Nadal, Lye M Tho, Xiuning Le, Julien Mazieres, How S Hin, Masahire Morise, Viola W Zhu, Daniel Tan, Kristina H Holmberg, Barbara Ellers-Lenz, Svenja Adrian, Sabine Brutlach, Karl M Schumacher, Niki Karachaliou, Yi-Long Wu
Publikováno v:
Future Oncology. 18:1039-1054
MET amplification (METamp), a mechanism of acquired resistance to EGFR tyrosine kinase inhibitors, occurs in up to 30% of patients with non-small-cell lung cancer (NSCLC) progressing on first-line osimertinib. Combining osimertinib with a MET inhibit
Autor:
Egbert, F Smit, Christophe, Dooms, Jo, Raskin, Ernest, Nadal, Lye M, Tho, Xiuning, Le, Julien, Mazieres, How, S Hin, Masahire, Morise, Viola, W Zhu, Daniel, Tan, Kristina, H Holmberg, Barbara, Ellers-Lenz, Svenja, Adrian, Sabine, Brutlach, Karl M, Schumacher, Niki, Karachaliou, Yi-Long, Wu
Publikováno v:
Future oncology (London, England). 18(9)
Osimertinib is used to treat a type of lung cancer that has specific changes (mutations) in a gene called
Publikováno v:
Viruses, Vol 9, Iss 7, p 174 (2017)
Oncogenic types of human papillomaviruses (HPVs) are major human carcinogens. The expression of the viral E6/E7 oncogenes plays a key role for HPV-linked oncogenesis. It recently has been found that low oxygen concentrations (“hypoxia”), as prese
Externí odkaz:
https://doaj.org/article/32681595378b44f38332815dc41f7c44
Autor:
J. Tabernero, Christophe Borg, E. Liu, L. Limon, C. López-López, Gene Grant Finley, S. Salim, Christophe Tournigand, John H. Strickler, Antonio Cubillo, Regina Esser, T. S. Bekaii-Saab, M.J. Safont Aguilera, Frank Beier, Svenja Adrian, Rocio Garcia-Carbonero, Nuria Rodríguez-Salas, Kanwal Pratap Singh Raghav
Publikováno v:
Annals of Oncology. 32:S136-S137
Autor:
Carlos Galvez, David Vicente Baz, Svenja Adrian, Jin-Hyoung Kang, Santiago Viteri, Young-Chul Kim, Jan P. van Meerbeeck, Karl-Maria Schumacher, Rolf Bruns, Niki Karachaliou, Paul K. Paik, Luis Paz-Ares, Xiuning Le
Publikováno v:
Journal of Clinical Oncology. 39:9021-9021
9021 Background: METamp is an oncogenic driver occurring in 1–5% of NSCLCs that confers a poor prognosis and lacks approved targeted therapies. Tepotinib, a highly selective MET inhibitor, provided durable response in NSCLC with MET exon 14 ( METex
Autor:
Felix Hoppe-Seyler, Arnulf Mayer, Mitsugu Shimobayashi, Prajakta Khalkar, Matthias Dürst, Stephen J. Kraemer, Bianca J. Kuhn, Felicitas Bossler, Svenja Adrian, Karin Hoppe-Seyler, Claudia Lohrey, Thomas Günther, Frank Rösl, Adam Grundhoff, Angela Holzer, Jeroen Krijgsveld
Publikováno v:
mBio, Vol 10, Iss 1, p e02323-18 (2019)
mBio
mBio, Vol 10, Iss 1 (2019)
mBio
mBio, Vol 10, Iss 1 (2019)
Oncogenic HPV types are major human carcinogens. Under hypoxia, HPV-positive cancer cells can repress the viral E6/E7 oncogenes and induce a reversible growth arrest. This response could contribute to therapy resistance, immune evasion, and tumor rec
Autor:
Tanios Bekaii-Saab, Frank Beier, Svenja Adrian, Josep Tabernero, Elena Elez, Jana Prausová, Cindy Neuzillet, Zev A. Wainberg, Eva Liu, Kanwal Pratap Singh Raghav, Filippo Pietrantonio, Stephen Falk, Shaista Salim, Nicole Campbell, Salvatore Siena, Eric Van Cutsem, Nicolas Isambert, Regina Esser
Publikováno v:
Journal of Clinical Oncology. 39:TPS149-TPS149
TPS149 Background: METamp is a secondary, or co-driving, genetic change in pts with mCRC and acquired resistance to anti-EGFR therapy, which can contribute to disease progression. In EGFR-resistant pts with mCRC and METamp, MET inhibition + an anti-E
Publikováno v:
Viruses, Vol 9, Iss 7, p 174 (2017)
Viruses
Viruses
Oncogenic types of human papillomaviruses (HPVs) are major human carcinogens. The expression of the viral E6/E7 oncogenes plays a key role for HPV-linked oncogenesis. It recently has been found that low oxygen concentrations (“hypoxia”), as prese
Autor:
Wojciech Pokrzywa, Jörg Höhfeld, Melek E. Akyuz, Riga Tawo, Svenja Adrian, Vishnu Balaji, Thorsten Hoppe, Éva Kevei
Publikováno v:
Worm
The integrity of the cellular proteome is supported by quality control networks, which govern protein synthesis, folding, and degradation. It is generally accepted that an age-related decline in protein homeostasis (proteostasis) contributes to prote