Mutations in the potassium channel subunit KCNE1 are associated with early-onset familial atrial fibrillation

Autor: Olesen Morten S, Bentzen Bo H, Nielsen Jonas B, Steffensen Annette B, David Jens-Peter, Jabbari Javad, Jensen Henrik K, Haunsø Stig, Svendsen Jesper H, Schmitt Nicole

Publikováno v: BMC Medical Genetics, Vol 13, Iss 1, p 24 (2012)

Abstract Background Atrial fibrillation (AF) is the most common arrhythmia. The potassium current IKs is essential for cardiac repolarization. Gain-of-function mutations in KV7.1, the pore-forming α-subunit of the IKs channel, have been associated w

Externí odkaz: https://doaj.org/article/1dc3558472c942e7b173ff90513fd37f

Whole-genome amplified DNA from stored dried blood spots is reliable in high resolution melting curve and sequencing analysis

Autor: Haunsø Stig, Svendsen Jesper H, Olesen Morten S, Hollegaard Mads V, Winkel Bo G, Hougaard David M, Tfelt-Hansen Jacob

Publikováno v: BMC Medical Genetics, Vol 12, Iss 1, p 22 (2011)

Abstract Background The use of dried blood spots (DBS) samples in genomic workup has been limited by the relative low amounts of genomic DNA (gDNA) they contain. It remains to be proven that whole genome amplified DNA (wgaDNA) from stored DBS samples

Externí odkaz: https://doaj.org/article/0e4ae761e82541f58bf359da336ad43b

Moderate-Affinity Affibodies Modulate the Delivery and Bioactivity of Bone Morphogenetic Protein-2.

Autor: Dorogin J; Department of Bioengineering, Knight Campus for Accelerating Scientific Impact, University of Oregon, 6231 University of Oregon, Eugene, OR, 97403, USA., Hochstatter HB; Department of Bioengineering, Knight Campus for Accelerating Scientific Impact, University of Oregon, 6231 University of Oregon, Eugene, OR, 97403, USA.; Department of Human Physiology, University of Oregon, 1320 E 15th Ave., Eugene, OR, 97403, USA., Shepherd SO; Department of Chemistry and Biochemistry, University of Oregon, 1253 University of Oregon, Eugene, OR, 97403, USA., Svendsen JE; Department of Bioengineering, Knight Campus for Accelerating Scientific Impact, University of Oregon, 6231 University of Oregon, Eugene, OR, 97403, USA.; Department of Chemistry and Biochemistry, University of Oregon, 1253 University of Oregon, Eugene, OR, 97403, USA., Benz MA; Department of Bioengineering, Knight Campus for Accelerating Scientific Impact, University of Oregon, 6231 University of Oregon, Eugene, OR, 97403, USA.; Department of Chemistry and Biochemistry, University of Oregon, 1253 University of Oregon, Eugene, OR, 97403, USA., Powers AC; Department of Bioengineering, Knight Campus for Accelerating Scientific Impact, University of Oregon, 6231 University of Oregon, Eugene, OR, 97403, USA., Fear KM; Department of Bioengineering, Knight Campus for Accelerating Scientific Impact, University of Oregon, 6231 University of Oregon, Eugene, OR, 97403, USA., Townsend JM; Department of Bioengineering, Knight Campus for Accelerating Scientific Impact, University of Oregon, 6231 University of Oregon, Eugene, OR, 97403, USA., Prell JS; Department of Chemistry and Biochemistry, University of Oregon, 1253 University of Oregon, Eugene, OR, 97403, USA., Hosseinzadeh P; Department of Bioengineering, Knight Campus for Accelerating Scientific Impact, University of Oregon, 6231 University of Oregon, Eugene, OR, 97403, USA.; Department of Chemistry and Biochemistry, University of Oregon, 1253 University of Oregon, Eugene, OR, 97403, USA., Hettiaratchi MH; Department of Bioengineering, Knight Campus for Accelerating Scientific Impact, University of Oregon, 6231 University of Oregon, Eugene, OR, 97403, USA.; Department of Chemistry and Biochemistry, University of Oregon, 1253 University of Oregon, Eugene, OR, 97403, USA.

Publikováno v: Advanced healthcare materials [Adv Healthc Mater] 2023 Oct; Vol. 12 (26), pp. e2300793. Date of Electronic Publication: 2023 Jul 09.

Structural and biochemical analyses of selectivity determinants in chimeric Streptococcus Class A sortase enzymes.

Autor: Gao M; Department of Chemistry, Western Washington University, Bellingham, Washington, USA., Johnson DA; Department of Chemistry, Western Washington University, Bellingham, Washington, USA., Piper IM; Department of Chemistry, Western Washington University, Bellingham, Washington, USA., Kodama HM; Department of Chemistry, Western Washington University, Bellingham, Washington, USA., Svendsen JE; Department of Chemistry, Western Washington University, Bellingham, Washington, USA., Tahti E; Department of Chemistry, Western Washington University, Bellingham, Washington, USA., Longshore-Neate F; Department of Chemistry, Western Washington University, Bellingham, Washington, USA., Vogel B; Department of Chemistry, Western Washington University, Bellingham, Washington, USA., Antos JM; Department of Chemistry, Western Washington University, Bellingham, Washington, USA., Amacher JF; Department of Chemistry, Western Washington University, Bellingham, Washington, USA.

Publikováno v: Protein science : a publication of the Protein Society [Protein Sci] 2022 Mar; Vol. 31 (3), pp. 701-715. Date of Electronic Publication: 2022 Jan 03.

Synchronization in G0/G1 enhances the mitogenic response of cells overexpressing the human insulin receptor A isoform to insulin.

Autor: Bonnesen C; Insulin Biology, Novo Nordisk Park C9.S.27, 2760, Maaloev, Denmark. crib@novonordisk.com, Nelander GM, Hansen BF, Jensen P, Krabbe JS, Jensen MB, Hegelund AC, Svendsen JE, Oleksiewicz MB

Publikováno v: Cell biology and toxicology [Cell Biol Toxicol] 2010 Aug; Vol. 26 (4), pp. 293-307. Date of Electronic Publication: 2009 Nov 08.