Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Svend Havelund"'
Autor:
Ib Jonassen, Svend Havelund, Frantisek Hubalek, Per-Olof Wahlund, Thomas Hoeg-Jensen, Ulla Ribel
Publikováno v:
Pharmaceutical Research
Purpose To study the self-association states of insulin degludec and insulin aspart alone and combined in pharmaceutical formulation and under conditions simulating the subcutaneous depot. Methods Formulations were made of 0.6 mM degludec at 3 and 5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03f508594563299b61128751678c51fa
http://europepmc.org/articles/PMC4452210
http://europepmc.org/articles/PMC4452210
Autor:
Katrine Nørgaard Toft, Bente Vestergaard, Gabriel David, Svend Havelund, M.H. Jensen, Javier Perez
Publikováno v:
Journal of Synchrotron Radiation. 17:769-773
Small-angle X-ray scattering (SAXS) is a powerful technique to structurally characterize biological macromolecules in solution. Heterogeneous solutions are inherently challenging to study. However, since SAXS data from ideal solutions are additive, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f4b248bd4acce693dcb86a7c4c62f4a
https://doi.org/10.1107/s0909049510030372
https://doi.org/10.1107/s0909049510030372
Publikováno v:
Journal of Pharmaceutical Sciences. 98:3265-3277
The insulin hexamer acts as an allosteric unit mediated by homotropic and heterotropic effects shifting the equilibrium between three distinct conformational states ( T 6 , R 3 T 3 and R 6 ). The homotropic ligand phenol stabilises the R 6 state by b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72144a3e6403bfde04e36d601aa7cb13
https://doi.org/10.1002/jps.21736
https://doi.org/10.1002/jps.21736
Publikováno v:
European Journal of Pharmaceutics and Biopharmaceutics. 70:828-838
Quality by design (QBD) refers to a holistic approach towards drug development. Important parts of QBD include definition of final product performance and understanding of formulation and process parameters. Inhalation of proteins for systemic distri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::119eed10224f960ee891614e5895defc
https://doi.org/10.1016/j.ejpb.2008.07.015
https://doi.org/10.1016/j.ejpb.2008.07.015
Publikováno v:
Pharmaceutical Research. 23:2611-2620
To study the correlation between the thermal and chemical stability of insulin formulations with various insulin hexamer ligands.The thermal stability was investigated using differential scanning calorimetry (DSC) and near-UV circular dichroism (NUV-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c5cace1890a500ef88872c30d1b6d41
https://doi.org/10.1007/s11095-006-9098-y
https://doi.org/10.1007/s11095-006-9098-y
Autor:
Marco van de Weert, Svend Havelund, Kasper Huus, Sven Frokjaer, Helle Birk Olsen, Bent W. Sigurskjold
Publikováno v:
Biochemistry. 45:4014-4024
The influence of ligand binding and conformation state on the thermostability of hexameric zinc-insulin was studied by differential scanning calorimetry (DSC). The insulin hexamer exists in equilibrium between the forms T6, T3R3, and R6. Phenolic lig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77ee91b69e326b633d7953431e402b8c
https://doi.org/10.1021/bi0524520
https://doi.org/10.1021/bi0524520
Autor:
Aage Vølund, Svend Havelund, Ib Jonassen, Mette Loftager, Ulla Ribel, Anne Plum, Jan Markussen, Thomas Hoeg-Jensen
Publikováno v:
Pharmaceutical Research. 23:49-55
This study was conducted to assess the suitability of insulin analogs acylated by various cholic acid derivatives for use as basal insulin, and to test the most promising of these, LysB29(N ɛ-lithocholyl-γ-Glu) des(B30) human insulin (NN344) in pig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc476816191b9ac1ea9ab132e5481cc4
https://doi.org/10.1007/s11095-005-9047-1
https://doi.org/10.1007/s11095-005-9047-1
Publikováno v:
Biochemistry. 44:11171-11177
The thermal stability of human insulin was studied by differential scanning microcalorimetry and near-UV circular dichroism as a function of zinc/protein ratio, to elucidate the dissociation and unfolding processes of insulin in different association
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fef11d4e46af4afdd3b0f2d0bd4d9cc4
https://doi.org/10.1021/bi0507940
https://doi.org/10.1021/bi0507940
Autor:
Per Vedsø, Jan Markussen, Lauge Schäffer, Ib Jonassen, Thomas Hoeg-Jensen, Signe Ridderberg, Preben H. Olesen, Per Balschmidt, Svend Havelund
Publikováno v:
Journal of Peptide Science. 11:339-346
Derivatization of insulin with phenylboronic acids is described, thereby equipping insulin with novel glucose sensing ability. It is furthermore demonstrated that such insulins are useful in glucose-responsive polymer-based release systems. The prefe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d6e17605fb3daccd75a19313c6f167b
https://doi.org/10.1002/psc.624
https://doi.org/10.1002/psc.624
Autor:
Svend Havelund, Morten Hach, Per Balschmidt, Jan Markussen, Annette Frost Pettersson, Thomas Kjeldsen
Publikováno v:
Protein Expression and Purification. 14:309-316
Synthetic prepro-leaders lacking consensus N-linked glycosylation sites confers secretion competence of correctly folded insulin precursor expressed in the yeast species Saccharomyces cerevisiae with a yield comparable to, or better than the alpha-fa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9504f5d8fbc12542d0f34448a8f7c94
https://doi.org/10.1006/prep.1998.0977
https://doi.org/10.1006/prep.1998.0977