Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Sven Weiler"'
Autor:
Thomas, Ullrich, Luca, Arista, Sven, Weiler, Sylvie, Teixeira-Fouchard, Valérie, Broennimann, Nikolaus, Stiefl, Victoria, Head, Ina, Kramer, Sabine, Guth
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 64:128667
Inhibition of mutant activin A type-1 receptor ACVR1 (ALK2) signaling by small-molecule drugs is a promising therapeutic approach to treat fibrodysplasia ossificans progressiva (FOP), an ultra-rare disease leading to progressive soft tissue heterotop
Autor:
Olivier Rogel, Tommasi Ruben A, J. R. Doughty, James Fang, Robert Goldstein, Raviraj Kulathila, Clayton Springer, Kirk Clark, Vishwas Ganu, Sven Weiler, Lijuan Zhu, Mark Chambers, Marc Walker, Stacey LaVoie, Jonathan E. Grob, Leslie Wighton Mcquire, Michael Shultz, Ronald L. Goldberg, Richard Melton, William Macchia, Jing Zhang
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:6440-6445
The matrix metalloproteinase enzyme MMP-13 plays a key role in the degradation of type II collagen in cartilage and bone in osteoarthritis (OA). An effective MMP-13 inhibitor would provide a disease modifying therapy for the treatment of arthritis, a
Publikováno v:
Journal of the American Chemical Society. 125:5393-5407
The evolution of a strategy culminating in an efficient, enantioselective synthesis of the potent microtubule-stabilizing agent FR182877 is described. Guided by a proposed biogenesis of this complex natural product, a solution emerged that involved t
Autor:
Honnappa Srinivas, Nadine Braendlin, Berndt Oberhauser, Christian Beerli, Andreas Billich, Anna Schubart, Christian Bergsdorf, Sven Weiler
Publikováno v:
Journal of medicinal chemistry. 57(12)
Sphingosine 1-phosphate (S1P) lyase has recently been implicated as a therapeutic target for the treatment of multiple sclerosis (MS), based on studies in a genetic mouse model. Potent active site directed inhibitors of the enzyme are not known so fa
Publikováno v:
Angewandte Chemie International Edition. 38:971-974
A 13-step synthesis of (±)-fumagillol (1), the direct precursor of the potent angiogenesis inhibitors TNP-470 and fumagillin, from crotonaldehyde, diethylamine, and acrolein (see the scheme) has been achieved. The synthesis features a remarkable het
Publikováno v:
Angewandte Chemie. 111:1024-1027
Autor:
Richard R. Schmidt, Sven Weiler
Publikováno v:
Tetrahedron Letters. 39:2299-2302
Based on readily available glucose, 2-azido-glucose, mannose, and N-phthaloyllactosamine building blocks 5, 6, 8, and 13 a highly versatile strategy for the synthesis of complex type and bisected complex type N-glycan residues is established; this is
Publikováno v:
Journal of Carbohydrate Chemistry. 15:241-254
Reaction of 2-O-unprotected 1-O-silyl-protected D-glucose and D-galactose derivatives 5a-d with benzyl bromide in the presence of sodium hydride as the base afforded 1-O-benzyl 2-O-silyl derivatives 6aα/β - 6dα/β. Thus, prior to anomeric O-benzyl
Publikováno v:
ChemInform. 27
Reaction of 2-O-unprotected 1-O-silyl-protected D-glucose and D-galactose derivatives 5a-d with benzyl bromide in the presence of sodium hydride as the base afforded 1-O-benzyl 2-O-silyl derivatives 6aα/β - 6dα/β. Thus, prior to anomeric O-benzyl
Autor:
Richard R. Schmidt, Sven Weiler
Publikováno v:
ChemInform. 29
Based on readily available glucose, 2-azido-glucose, mannose, and N-phthaloyllactosamine building blocks 5, 6, 8, and 13 a highly versatile strategy for the synthesis of complex type and bisected complex type N-glycan residues is established; this is