Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Sven W. Sauer"'
Autor:
Gustavo A. Bezerra, William R. Foster, Henry J. Bailey, Kevin G. Hicks, Sven W. Sauer, Bianca Dimitrov, Thomas J. McCorvie, Jürgen G. Okun, Jared Rutter, Stefan Kölker, Wyatt W. Yue
Publikováno v:
IUCrJ, Vol 7, Iss 4, Pp 693-706 (2020)
DHTKD1 is a lesser-studied E1 enzyme among the family of 2-oxoacid dehydrogenases. In complex with E2 (dihydrolipoamide succinyltransferase, DLST) and E3 (dihydrolipoamide dehydrogenase, DLD) components, DHTKD1 is involved in lysine and tryptophan ca
Externí odkaz:
https://doaj.org/article/f5c7b911e55a49b5ba415171e6dd2ab1
Autor:
Georg Gdynia, Sven W. Sauer, Jürgen Kopitz, Dominik Fuchs, Katarina Duglova, Thorsten Ruppert, Matthias Miller, Jens Pahl, Adelheid Cerwenka, Markus Enders, Heimo Mairbäurl, Marcin M. Kamiński, Roland Penzel, Christine Zhang, Jonathan C. Fuller, Rebecca C. Wade, Axel Benner, Jenny Chang-Claude, Hermann Brenner, Michael Hoffmeister, Hanswalter Zentgraf, Peter Schirmacher, Wilfried Roth
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
HMBG1 is a protein expressed in natural killer cells and is important in immunosurveillance. In this study, the authors show that HMGB1 binds to and inhibits PKM2, resulting in a block in aerobic glycolysis and ultimately cell death.
Externí odkaz:
https://doaj.org/article/6d0982f20a704f85b9b090631aa6eb7d
Autor:
Marcin M. Kamiński, Sven W. Sauer, Marian Kamiński, Silvana Opp, Thorsten Ruppert, Paulius Grigaravičius, Przemysław Grudnik, Hermann-Josef Gröne, Peter H. Krammer, Karsten Gülow
Publikováno v:
Cell Reports, Vol 2, Iss 5, Pp 1300-1315 (2012)
Mitochondria-originating reactive oxygen species (ROS) control T cell receptor (TCR)-induced gene expression. Here, we show that TCR-triggered activation of ADP-dependent glucokinase (ADPGK), an alternative, glycolytic enzyme typical for Archaea, med
Externí odkaz:
https://doaj.org/article/96ce577eec5b4fd6998e231b2ec9cac5
Autor:
Wyatt W. Yue, Thomas J. McCorvie, Bianca Dimitrov, Henry J. Bailey, Kevin G. Hicks, Stefan Kölker, Sven W. Sauer, Gustavo Arruda Bezerra, Juergen G. Okun, W. Foster, Jared Rutter
Publikováno v:
IUCrJ, Vol 7, Iss 4, Pp 693-706 (2020)
IUCrJ
IUCrJ
Through interaction studies, the crystal structure of human DHTKD1 allows insight into a mitochondrial megacomplex in lysine catabolism. This creates the starting framework for developing DHTKD1 modulators to probe the intricate mitochondrial energy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6477f2f702f20628cd60b07635802f1
https://doi.org/10.1107/s205225252000696x
https://doi.org/10.1107/s205225252000696x
Autor:
Guenter Haemmerle, Christoph Dieterich, Tamás Fischer, Sven W. Sauer, Monika Oberer, Jens Tyedmers, Hugo A. Katus, Patrick Most, Lorenz H. Lehmann, Oliver J. Müller, Lisa Wechselberger, Barbara C. Worst, Dominik Siede, Samuel Sossalla, Kumar D Shanmukha, Friederike C. Schreiter, Zegeye H Jebessa, Chang Xu, Johannes Backs, Matthias Dewenter, Giuseppina Federico, Xue-Min Gong, Cedric Moro, Herrmann-Josef Gröne
Publikováno v:
Nature metabolism
Catecholamines stimulate the first step of lipolysis by PKA-dependent release of the lipid droplet-associated protein ABHD5 from perilipin to co-activate the lipase ATGL. Here, we unmask a yet unrecognized proteolytic and cardioprotective function of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dab45232ee7a995811007916b363af7e
https://doi.org/10.1038/s42255-019-0138-4
https://doi.org/10.1038/s42255-019-0138-4
Autor:
Mirko Völkers, Jana Birkenhagen, Anne Schröder, Jonathan Bones, Christian Thiel, Sara Carillo, Roland Imle, Nastassja Himmelreich, Hermann Josef Gröne, Karsten Gülow, Amol Tandon, Stefan Mittermayr, Nicolas Stützenberger, Stefan Kölker, Marcin Kamiński, Bei-Tzu Wang, Sven W. Sauer, Gernot Poschet, Matthias Carl
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
Scientific Reports
Scientific Reports
Modulation of energy metabolism to a highly glycolytic phenotype, i.e. Warburg effect, is a common phenotype of cancer and activated immune cells allowing increased biomass-production for proliferation and cell division. Endoplasmic reticulum (ER)-lo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d79785f888ef47463ca76b7f3e14e4c
http://link.springer.com/article/10.1038/s41598-019-50566-6
http://link.springer.com/article/10.1038/s41598-019-50566-6
Autor:
Julia Calzada-Wack, D. S. Froese, Johannes Beckers, Céline Bürer, G. T. Bommer, Jan Rozman, Andres Kaech, M. Forny, Daniel Hoces, J. P. Dewulf, Samuel E. Wuest, Stefan Kölker, M. Lucienne, Patrick Forny, Martin Irmler, Sven W. Sauer, Helmut Fuchs, Juan Antonio Aguilar-Pimentel, Matthias R. Baumgartner, F. Traversi, Birgit Rathkolb, Raffaele Gerlini, V. Gailus-Durner, M Hrabe de Angelis
Inherited disorders of mitochondrial metabolism, including isolated methylmalonic aciduria (MMAuria), present unique challenges to energetic homeostasis by disrupting energy producing pathways. To better understand global responses to energy shortage
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f807772e231686f795ef581b2548d2a8
https://www.zora.uzh.ch/id/eprint/213084/
https://www.zora.uzh.ch/id/eprint/213084/
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-16 (2020)
Scientific Reports
Scientific Reports
Warburg effect or aerobic glycolysis provides selective growth advantage to aggressive cancers. However, targeting oncogenic regulators of Warburg effect has always been challenging owing to the wide spectrum of roles of these molecules in multitude
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dab901bd6071d0e8f22c84aaa1410f45
https://doi.org/10.1038/s41598-020-70014-0
https://doi.org/10.1038/s41598-020-70014-0
Autor:
Anne-Claude Gavin, Akihisa Yamamoto, Georg F. Hoffmann, Sven W. Sauer, Vladimir Benes, Laura Poisa-Beiro, Natalie Romanov, Judith Thoma, Anthony D. Ho, Motomu Tanaka, Jonathan J M Landry, Simon Raffel, Peer Bork, Volker Eckstein
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
Scientific Reports, Vol. 10, No 1 (2020) P. 11597
Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
Scientific Reports, Vol. 10, No 1 (2020) P. 11597
Inspired by recent proteomic data demonstrating the upregulation of carbon and glycogen metabolism in aging human hematopoietic stem and progenitor cells (HPCs, CD34+ cells), this report addresses whether this is caused by elevated glycolysis of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::824543b7b918f549bd6e5fd29d3e5001
https://doi.org/10.1038/s41598-020-68396-2
https://doi.org/10.1038/s41598-020-68396-2
Autor:
Stefan Koelker, Gustavo Arruda Bezerra, Wyatt W. Yue, Bianca Dimitrov, W. Foster, Juergen G. Okun, Henry J. Bailey, Kevin G. Hicks, Sven W. Sauer, Jared Rutter
DHTKD1 is a lesser-studied E1 enzyme belonging to the family of 2-oxoacid dehydrogenases. DHTKD1, in complex with the E2 (dihydrolipoamide succinyltransferase, DLST) and E3 (lipoamide dehydrogenase, DLD) components, is implicated in lysine and trypto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c8a16e9d63d7a950481acbae5e813bb