Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Sven Vilain"'
Autor:
Sven Vilain
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
Externí odkaz:
https://doaj.org/article/40aef4a16c4c433280243648a5f1ea1a
Autor:
Lujia Zhou, Joseph McInnes, Keimpe Wierda, Matthew Holt, Abigail G. Herrmann, Rosemary J. Jackson, Yu-Chun Wang, Jef Swerts, Jelle Beyens, Katarzyna Miskiewicz, Sven Vilain, Ilse Dewachter, Diederik Moechars, Bart De Strooper, Tara L. Spires-Jones, Joris De Wit, Patrik Verstreken
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Mislocalisation of tau occurs in several neurodegenerative diseases and is thought to contribute to synaptic function. The authors show that presynaptically, tau binds to synaptic vesicles via the N-terminus which contributes to synaptic dysfunction.
Externí odkaz:
https://doaj.org/article/29d0e0f57e0642e99099f85ef88b2518
Autor:
Tom Cornelissen, Sven Vilain, Katlijn Vints, Natalia Gounko, Patrik Verstreken, Wim Vandenberghe
Publikováno v:
eLife, Vol 7 (2018)
Mutations in the genes for PINK1 and parkin cause Parkinson’s disease. PINK1 and parkin cooperate in the selective autophagic degradation of damaged mitochondria (mitophagy) in cultured cells. However, evidence for their role in mitophagy in vivo i
Externí odkaz:
https://doaj.org/article/3a7b992f0f33432b804d642094f9efb0
Autor:
Giovanni Esposito, Melissa Vos, Sven Vilain, Jef Swerts, Jorge De Sousa Valadas, Stefanie Van Meensel, Onno Schaap, Patrik Verstreken
Publikováno v:
PLoS Genetics, Vol 9, Iss 4, p e1003478 (2013)
The PTEN-induced kinase 1 (PINK1) is a mitochondrial kinase, and pink1 mutations cause early onset Parkinson's disease (PD) in humans. Loss of pink1 in Drosophila leads to defects in mitochondrial function, and genetic data suggest that another PD-re
Externí odkaz:
https://doaj.org/article/564fb14719d54e73b92ed880fbc2a0f8
Autor:
Sven Vilain, Giovanni Esposito, Dominik Haddad, Onno Schaap, Mariya P Dobreva, Melissa Vos, Stefanie Van Meensel, Vanessa A Morais, Bart De Strooper, Patrik Verstreken
Publikováno v:
PLoS Genetics, Vol 8, Iss 1, p e1002456 (2012)
Pink1 is a mitochondrial kinase involved in Parkinson's disease, and loss of Pink1 function affects mitochondrial morphology via a pathway involving Parkin and components of the mitochondrial remodeling machinery. Pink1 loss also affects the enzymati
Externí odkaz:
https://doaj.org/article/fab4c4340126431da8700027a5a93c2d
Autor:
Stein Aerts, Sven Vilain, Shu Hu, Leon-Charles Tranchevent, Roland Barriot, Jiekun Yan, Yves Moreau, Bassem A Hassan, Xiao-Jiang Quan
Publikováno v:
PLoS Genetics, Vol 5, Iss 1, p e1000351 (2009)
Genetic screens are powerful methods for the discovery of gene-phenotype associations. However, a systems biology approach to genetics must leverage the massive amount of "omics" data to enhance the power and speed of functional gene discovery in viv
Externí odkaz:
https://doaj.org/article/48b8e25fcd7f4b29aabd731c461451d8
Autor:
Hamza Yusuf Altun, Melike Secilmis, Tuba Akgul Caglar, Emre Vatandaslar, Gürkan Öztürk, Sven Vilain, Emrah Eroglu
The relationship between hydrogen peroxide (H2O2) and nitric oxide (NO) in the vasculature is multifaceted and remains controversial because the dynamic detection of these reactive molecules is challenging. Genetically encoded biosensors (GEBs) allow
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4bbb7f49767838196a70d0e417056066
https://doi.org/10.1101/2023.02.15.528776
https://doi.org/10.1101/2023.02.15.528776
Autor:
Joachim G. Schulz, Leen Van Huffel, Paul P. Van Veldhoven, Jarl Bastianen, Annette Gärtner, Sven Vilain, Antonio Laranjeira, Carlos G. Dotti
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-1 (2020)
Scientific Reports
Scientific Reports
The brain's impotence to utilize long-chain fatty acids as fuel, one of the dogmas in neuroscience, is surprising, since the nervous system is the tissue most energy consuming and most vulnerable to a lack of energy. Challenging this view, we here sh
Autor:
Joris de Wit, Sven Vilain, Keimpe D. Wierda, Abigail G. Herrmann, Matthew Holt, Yu-Chun Wang, Patrik Verstreken, Bart De Strooper, Jelle Beyens, Ilse Dewachter, Lujia Zhou, Tara L. Spires-Jones, Diederik Moechars, Joseph McInnes, Jef Swerts, Rosemary J. Jackson, Katarzyna Miskiewicz
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Nature Communications
Zhou, L, McInnes, J, Wierda, K, Holt, M, Herrmann, A G, Jackson, R J, Wang, Y-C, Swerts, J, Beyens, J, Miskiewicz, K, Vilain, S, Dewachter, I, Moechars, D, De Strooper, B, Spires-Jones, T L, De Wit, J & Verstreken, P 2017, ' Tau association with synaptic vesicles causes presynaptic dysfunction ', Nature Communications, vol. 8, 15295 . https://doi.org/10.1038/ncomms15295
Nature Communications
Zhou, L, McInnes, J, Wierda, K, Holt, M, Herrmann, A G, Jackson, R J, Wang, Y-C, Swerts, J, Beyens, J, Miskiewicz, K, Vilain, S, Dewachter, I, Moechars, D, De Strooper, B, Spires-Jones, T L, De Wit, J & Verstreken, P 2017, ' Tau association with synaptic vesicles causes presynaptic dysfunction ', Nature Communications, vol. 8, 15295 . https://doi.org/10.1038/ncomms15295
Tau is implicated in more than 20 neurodegenerative diseases, including Alzheimer's disease. Under pathological conditions, Tau dissociates from axonal microtubules and missorts to pre- and postsynaptic terminals. Patients suffer from early synaptic
Autor:
Wim Mandemakers, Sabine Kuenen, Vincenzo Bonifati, Sandra-Fausia Soukup, Sven Vilain, Femke M.S. de Vrij, Marina Picillo, Julia Manetsberger, Serguei Gontcharenko, Frederic A. Meunier, Patrik Verstreken, Adekunle T. Bademosi, Nils Schoovaerts, Jef Swerts, Natalia V. Gounko, Roy Masius, Shashini T. Munshi, Steven A. Kushner, Paolo Barone, Roeland Vanhauwaert, Laura Bounti
Publikováno v:
The EMBO Journal
EMBO J
EMBO Journal, 36(10), 1392-1411. Wiley-Blackwell
EMBO J
EMBO Journal, 36(10), 1392-1411. Wiley-Blackwell
Presynaptic terminals are metabolically active and accrue damage through continuous vesicle cycling. How synapses locally regulate protein homeostasis is poorly understood. We show that the presynaptic lipid phosphatase synaptojanin is required for m