Mass spectrometry-driven discovery of neuropeptides mediating nictation behavior of nematodes

Autor: Bram Cockx, Sven Van Bael, Rose Boelen, Elke Vandewyer, Heeseung Yang, Tuan Anh Le, Johnathan J. Dalzell, Isabel Beets, Christina Ludwig, Junho Lee, Liesbet Temmerman

Publikováno v: Cockx, B, Van Bael, S, Boelen, R, Vandewyer, E, Yang, H, Le, T A, Dalzell, J J, Beets, I, Ludwig, C, Lee, J & Temmerman, L 2023, ' Mass spectrometry-driven discovery of neuropeptides mediating nictation behavior of nematodes ', Molecular and Cellular Proteomics, vol. 22, no. 2, 100479 . https://doi.org/10.1016/j.mcpro.2022.100479

Neuropeptides regulate animal physiology and behavior, making them widely studied targets of functional genetics research. While the field often relies on differential -omics approaches to build hypotheses, no such method exists for neuropeptidomics.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2e437208fa89f340acb0934c329e017
https://pure.qub.ac.uk/en/publications/2d030ad5-7804-4b12-b843-d3a10986d67b

Mass spectrometric evidence for neuropeptide-amidating enzymes in

Autor: Jan Watteyne, Niels Ringstad, Gerben Menschaert, Liliane Schoofs, H. Robert Horvitz, Kurt Boonen, Steven J. Husson, Sven Van Bael, Wouter De Haes, Liesbet Temmerman

Publikováno v: Journal of Biological Chemistry. 293:6052-6063

Neuropeptides constitute a vast and functionally diverse family of neurochemical signaling molecules and are widely involved in the regulation of various physiological processes. The nematode Caenorhabditis elegans is well-suited for the study of neu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ebc835aba91b2a0d02a7ebe8b12e369
https://doi.org/10.1074/jbc.ra117.000731

Beyond ROS clearance: Peroxiredoxins in stress signaling and aging

Autor: Samantha Louise Edwards, Lucas Mergan, Wouter De Haes, Liesbet Temmerman, Giel Detienne, Sven Van Bael

Publikováno v: Ageing research reviews. 44

Antioxidants were long predicted to have lifespan-promoting effects, but in general this prediction has not been well supported. While some antioxidants do seem to have a clear effect on longevity, this may not be primarily as a result of their role

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5631e024477ee1f75c2c2060dbf85a10
https://pubmed.ncbi.nlm.nih.gov/29580920

A Caenorhabditis elegans mass spectrometric resource for neuropeptidomics

Autor: Liliane Schoofs, Kurt Boonen, Isabel Beets, Sven Zels, Sven Van Bael, Liesbet Temmerman

Publikováno v: Journal of the American Society for Mass Spectrometry

Neuropeptides are important signaling molecules used by nervous systems to mediate and fine-tune neuronal communication. They can function as neurotransmitters or neuromodulators in neural circuits, or they can be released as neurohormones to target

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ecc494efdf798263c66fee3941ebe13
https://lirias.kuleuven.be/handle/123456789/632174