Zobrazeno 1 - 10
of 68
pro vyhledávání: '"Sven Thoms"'
Publikováno v:
Biology Direct, Vol 19, Iss 1, Pp 1-14 (2024)
Abstract Peroxisomes are primarily studied in the brain, kidney, and liver due to the conspicuous tissue-specific pathology of peroxisomal biogenesis disorders. In contrast, little is known about the role of peroxisomes in other tissues such as the h
Externí odkaz:
https://doaj.org/article/3310a2b6de5b4138b6f7b11bd9b1dfeb
Autor:
Amnon Wittenstein, Michal Caspi, Ido Rippin, Orna Elroy-Stein, Hagit Eldar-Finkelman, Sven Thoms, Rina Rosin-Arbesfeld
Publikováno v:
PLoS Biology, Vol 21, Iss 11, p e3002355 (2023)
The introduction of premature termination codons (PTCs), as a result of splicing defects, insertions, deletions, or point mutations (also termed nonsense mutations), lead to numerous genetic diseases, ranging from rare neuro-metabolic disorders to re
Externí odkaz:
https://doaj.org/article/326ee8ebb9fd4674935f832a707e601c
Autor:
Nazar Oleksiievets, Yelena Sargsyan, Jan Christoph Thiele, Nikolaos Mougios, Shama Sograte-Idrissi, Oleksii Nevskyi, Ingo Gregor, Felipe Opazo, Sven Thoms, Jörg Enderlein, Roman Tsukanov
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-8 (2022)
Oleksiievets et al. combine single-molecule localization super-resolution microscopy technique DNA-PAINT with fluorescence lifetime imaging to allow fast multi-target super-resolution imaging in one spectral region by separating two or three differen
Externí odkaz:
https://doaj.org/article/11f38fcb80294114a5b25445853266b1
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Calcium is a central signal transduction element in biology. Peroxisomes are essential cellular organelles, yet calcium handling in peroxisomes has been contentious. Recent advances show that peroxisomes are part of calcium homeostasis in cardiac myo
Externí odkaz:
https://doaj.org/article/ffe287a08ebe4254b15a475d61828290
Publikováno v:
Biomolecules, Vol 11, Iss 7, p 1006 (2021)
Premature termination codon (PTC) mutations account for approximately 10% of pathogenic variants in monogenic diseases. Stimulation of translational readthrough, also known as stop codon suppression, using translational readthrough-inducing drugs (TR
Externí odkaz:
https://doaj.org/article/8cf12eee718848faad50794aa5d23abc
Autor:
Anna V. Bulankina, Sven Thoms
Publikováno v:
Cells, Vol 9, Iss 3, p 534 (2020)
Ferlins are multiple-C2-domain proteins involved in Ca2+-triggered membrane dynamics within the secretory, endocytic and lysosomal pathways. In bony vertebrates there are six ferlin genes encoding, in humans, dysferlin, otoferlin, myoferlin, Fer1L5 a
Externí odkaz:
https://doaj.org/article/8201797175764a53877a9fe57a43bf66
Autor:
Fabian Schueren, Sven Thoms
Publikováno v:
PLoS Genetics, Vol 12, Iss 8, p e1006196 (2016)
Translational readthrough (TR) has come into renewed focus because systems biology approaches have identified the first human genes undergoing functional translational readthrough (FTR). FTR creates functional extensions to proteins by continuing tra
Externí odkaz:
https://doaj.org/article/224b3d2624de4f2582992f5971901034
Autor:
Julia Hofhuis, Fabian Schueren, Christopher Nötzel, Thomas Lingner, Jutta Gärtner, Olaf Jahn, Sven Thoms
Publikováno v:
Open Biology, Vol 6, Iss 11 (2016)
Translational readthrough gives rise to C-terminally extended proteins, thereby providing the cell with new protein isoforms. These may have different properties from the parental proteins if the extensions contain functional domains. While for most
Externí odkaz:
https://doaj.org/article/03aca3f59666453abc0d56dffde762a7
Publikováno v:
Disease Models & Mechanisms, Vol 5, Iss 2, Pp 259-269 (2012)
SUMMARY Endoplasmic reticulum stress signaling (ERSS) plays an important role in the pathogenesis of diabetes and heart disease. The latter is a common comorbidity of diabetes and worsens patient outcome. Results from clinical studies suggest benefic
Externí odkaz:
https://doaj.org/article/f22a2218f1a44529a233acc23f7f0940
Autor:
Sven Thoms
Publikováno v:
Open Biology, Vol 5, Iss 11 (2015)
Peroxisomes are capable of importing folded and oligomeric proteins. However, it is a matter of dispute whether oligomer import by peroxisomes is the exception or the rule. Here, I argue for a clear distinction between homo-oligomeric proteins that a
Externí odkaz:
https://doaj.org/article/d9bfaf315b514700a33ab7d1472ebdd3