Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Sven T. Sowa"'
Autor:
Dr. Patricia Korn, Arno Classen, Dr. Sudarshan Murthy, Dr. Riccardo Guareschi, Mirko M. Maksimainen, Barbara E. Lippok, Albert Galera‐Prat, Sven T. Sowa, Catharina Voigt, Prof. Dr. Giulia Rossetti, Prof. Dr. Lari Lehtiö, Prof. Dr. Carsten Bolm, Prof. Dr. Bernhard Lüscher
Publikováno v:
ChemistryOpen, Vol 10, Iss 10, Pp 939-948 (2021)
Abstract Intracellular ADP‐ribosyltransferases catalyze mono‐ and poly‐ADP‐ribosylation and affect a broad range of biological processes. The mono‐ADP‐ribosyltransferase PARP10 is involved in signaling and DNA repair. Previous studies ide
Externí odkaz:
https://doaj.org/article/0e125f0171b24e93b9aec1f09fcdc7ff
Autor:
Sven T. Sowa, Albert Galera-Prat, Sarah Wazir, Heli I. Alanen, Mirko M. Maksimainen, Lari Lehtiö
Publikováno v:
STAR Protocols, Vol 3, Iss 1, Pp 101147- (2022)
Summary: Here, we describe a protocol to set up a screening assay for ADP-ribosyl binding proteins including proteins that possess O-glycosidase or N-glycosidase activities. The FRET-based assay measures the interaction of any ADP-ribosyl binding pro
Externí odkaz:
https://doaj.org/article/5757d53f46f04a1595194b95e88c4132
Autor:
Sven T. Sowa, Lari Lehtiö
Publikováno v:
Open Biology, Vol 12, Iss 3 (2022)
Tankyrases are ADP-ribosylating enzymes that regulate many physiological processes in the cell and are considered promising drug targets for cancer and fibrotic diseases. The catalytic ADP-ribosyltransferase domain of tankyrases contains a unique zin
Externí odkaz:
https://doaj.org/article/b2253f59b8f24166961bffcaa7875e73
Publikováno v:
Biomolecules, Vol 12, Iss 11, p 1688 (2022)
Tankyrases are poly-ADP-ribosyltransferases that regulate many crucial and diverse cellular processes in humans such as Wnt signaling, telomere homeostasis, mitotic spindle formation and glucose metabolism. While tankyrases are present in most animal
Externí odkaz:
https://doaj.org/article/c88ed3dc5bc543089e8f5ee72fa3dd34
Autor:
Jo Waaler, Stefan Krauss, Anita Wegert, Ruben G.G. Leenders, Ilonka A.T.M. Meerts, Lari Lehtiö, Albert Galera-Prat, Sven T. Sowa, Gunnveig Grødeland, Hanne Scholz, Merete Høyem, Lone Holmen, Petter A. Olsen, Aleksandra Aizenshtadt, Clara Hammarström, Sandra Espada, Enya Amundsen-Isaksen, Shoshy A. Brinch
Supplementary Figure S1. Chemical structures of selected tankyrase inhibitors. Supplementary Figure S2. OM-153 specifically inhibits TNKS1/2 and WNT/β-catenin signaling. Supplementary Figure S3. OM-153 specifically inhibits cell growth of an APC-mut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ae321b85444944ba3b4b1f59b1193c2
https://doi.org/10.1158/2767-9764.22544588.v1
https://doi.org/10.1158/2767-9764.22544588.v1
Autor:
Jo Waaler, Stefan Krauss, Anita Wegert, Ruben G.G. Leenders, Ilonka A.T.M. Meerts, Lari Lehtiö, Albert Galera-Prat, Sven T. Sowa, Gunnveig Grødeland, Hanne Scholz, Merete Høyem, Lone Holmen, Petter A. Olsen, Aleksandra Aizenshtadt, Clara Hammarström, Sandra Espada, Enya Amundsen-Isaksen, Shoshy A. Brinch
The catalytic enzymes tankyrase 1 and 2 (TNKS1/2) alter protein turnover by poly-ADP-ribosylating target proteins, which earmark them for degradation by the ubiquitin–proteasomal system. Prominent targets of the catalytic activity of TNKS1/2 includ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f93c195c48b8a1da60a3074acb0277a
https://doi.org/10.1158/2767-9764.c.6550697
https://doi.org/10.1158/2767-9764.c.6550697
Autor:
Shoshy A. Brinch, Enya Amundsen-Isaksen, Sandra Espada, Clara Hammarström, Aleksandra Aizenshtadt, Petter A. Olsen, Lone Holmen, Merete Høyem, Hanne Scholz, Gunnveig Grødeland, Sven T. Sowa, Albert Galera-Prat, Lari Lehtiö, Ilonka A.T.M. Meerts, Ruben G.G. Leenders, Anita Wegert, Stefan Krauss, Jo Waaler
Publikováno v:
Cancer Research Communications. 2:233-245
The catalytic enzymes tankyrase 1 and 2 (TNKS1/2) alter protein turnover by poly-ADP-ribosylating target proteins, which earmark them for degradation by the ubiquitin–proteasomal system. Prominent targets of the catalytic activity of TNKS1/2 includ
Autor:
Sudarshan, Murthy, Maria Giulia, Nizi, Mirko M, Maksimainen, Serena, Massari, Juho, Alaviuhkola, Barbara E, Lippok, Chiara, Vagaggini, Sven T, Sowa, Albert, Galera-Prat, Yashwanth, Ashok, Harikanth, Venkannagari, Renata, Prunskaite-Hyyryläinen, Elena, Dreassi, Bernhard, Lüscher, Patricia, Korn, Oriana, Tabarrini, Lari, Lehtiö
Publikováno v:
Journal of medicinal chemistry.
We report [1,2,4]triazolo[3,4
Autor:
Sudarshan Murthy, Maria Giulia Nizi, Mirko M. Maksimainen, Serena Massari, Juho Alaviuhkola, Barbara E. Lippok, Chiara Vagaggini, Sven T. Sowa, Albert Galera-Prat, Yashwanth Ashok, Harikanth Venkannagari, Renata Prunskaite-Hyyryläinen, Elena Dreassi, Bernhard Lüscher, Patricia Korn, Oriana Tabarrini, Lari Lehtiö
Publikováno v:
Journal of medicinal chemistry 66(2), 1301-1320 (2023). doi:10.1021/acs.jmedchem.2c01460
Journal of medicinal chemistry 66(2), 1301-1320 (2023). doi:10.1021/acs.jmedchem.2c01460
Published by American Chemical Society, Washington, DC
Published by American Chemical Society, Washington, DC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d02c78b88c3e04c15acc5405940609a1
http://urn.fi/urn:nbn:fi-fe2023032232837
http://urn.fi/urn:nbn:fi-fe2023032232837
Autor:
Patricia Korn, Lari Lehtiö, Bernhard Lüscher, Sven T. Sowa, Arno Classen, Giulia Rossetti, Barbara E. Lippok, Mirko M. Maksimainen, Carsten Bolm, Riccardo Guareschi, Albert Galera-Prat, Sudarshan Murthy, Catharina Voigt
Publikováno v:
ChemistryOpen
ChemistryOpen, Vol 10, Iss 10, Pp 939-948 (2021)
ChemistryOpen : including thesis treasury 10(10), 939-948 (2021). doi:10.1002/open.202100087
ChemistryOpen 10(10), 939-948 (2021). doi:10.1002/open.202100087
ChemistryOpen, Vol 10, Iss 10, Pp 939-948 (2021)
ChemistryOpen : including thesis treasury 10(10), 939-948 (2021). doi:10.1002/open.202100087
ChemistryOpen 10(10), 939-948 (2021). doi:10.1002/open.202100087
Intracellular ADP‐ribosyltransferases catalyze mono‐ and poly‐ADP‐ribosylation and affect a broad range of biological processes. The mono‐ADP‐ribosyltransferase PARP10 is involved in signaling and DNA repair. Previous studies identified O