Zobrazeno 1 - 10
of 77
pro vyhledávání: '"Sven Stringer"'
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Gene-set analysis (GSA) is widely used to infer functional and biological properties of a gene set. Here, the authors develop a conditional and interaction gene-set analysis approach that can considerably refine results from traditional GSA.
Externí odkaz:
https://doaj.org/article/241c1127ce014dceaa058d324b4c6adf
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
Neuroticism can be assessed as a composite score of individual items. Here, Nagel et al. perform genetic association studies for 12 neuroticism items and the sum-score and demonstrate genetic heterogeneity at the item-level.
Externí odkaz:
https://doaj.org/article/7e9fd55c065d4717ac52709cbb4a6ab9
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 11 (2017)
Induced pluripotent stem cell (iPSC) technology is more and more used for the study of genetically complex human disease but is challenged by variability, sample size and polygenicity. We discuss studies involving iPSC-derived neurons from patients w
Externí odkaz:
https://doaj.org/article/f9459cd7b2fb4d7399e644553fdbe6a4
Autor:
Christiaan de Leeuw, Kyoko Watanabe, Sophie van der Sluis, Benjamin M. Neale, Ole A. Andreassen, Oleksandr Frei, Tinca J. C. Polderman, Danielle Posthuma, Sven Stringer, Maša Umićević Mirkov
Publikováno v:
Nature Genetics, 51(September), 1339-1348. Nature Publishing Group
Watanabe, K, Stringer, S, Frei, O, Umićević Mirkov, M, de Leeuw, C, Polderman, T J C, van der Sluis, S, Andreassen, O A, Neale, B M & Posthuma, D 2019, ' A global overview of pleiotropy and genetic architecture in complex traits ', Nature Genetics, vol. 51, no. 9, pp. 1339-1348 . https://doi.org/10.1038/s41588-019-0481-0
Watanabe, K, Stringer, S, Frei, O, Umićević Mirkov, M, de Leeuw, C, Polderman, T J C, van der Sluis, S, Andreassen, O A, Neale, B M & Posthuma, D 2019, ' A global overview of pleiotropy and genetic architecture in complex traits ', Nature Genetics, vol. 51, no. September, pp. 1339-1348 . https://doi.org/10.1038/s41588-019-0481-0
Nature Genetics, 51(9), 1339-1348. Nature Publishing Group
Watanabe, K, Stringer, S, Frei, O, Umićević Mirkov, M, de Leeuw, C, Polderman, T J C, van der Sluis, S, Andreassen, O A, Neale, B M & Posthuma, D 2019, ' A global overview of pleiotropy and genetic architecture in complex traits ', Nature Genetics, vol. 51, no. 9, pp. 1339-1348 . https://doi.org/10.1038/s41588-019-0481-0
Watanabe, K, Stringer, S, Frei, O, Umićević Mirkov, M, de Leeuw, C, Polderman, T J C, van der Sluis, S, Andreassen, O A, Neale, B M & Posthuma, D 2019, ' A global overview of pleiotropy and genetic architecture in complex traits ', Nature Genetics, vol. 51, no. September, pp. 1339-1348 . https://doi.org/10.1038/s41588-019-0481-0
Nature Genetics, 51(9), 1339-1348. Nature Publishing Group
After a decade of genome-wide association studies (GWASs), fundamental questions in human genetics, such as the extent of pleiotropy across the genome and variation in genetic architecture across traits, are still unanswered. The current availability
Autor:
Ka Wan Li, Iryna Paliukhovich, Titia Gebuis, Patrick F. Sullivan, Danielle Posthuma, Martina Rosato, Ronald E. van Kesteren, Sven Stringer, August B. Smit
Publikováno v:
Molecular Psychiatry
Molecular Psychiatry, 26(3), 784-799. Nature Publishing Group
Rosato, M, Stringer, S, Gebuis, T, Paliukhovich, I, Li, K W, Posthuma, D, Sullivan, P F, Smit, A B & van Kesteren, R E 2021, ' Combined cellomics and proteomics analysis reveals shared neuronal morphology and molecular pathway phenotypes for multiple schizophrenia risk genes ', Molecular Psychiatry, vol. 26, no. 3, pp. 784-799 . https://doi.org/10.1038/s41380-019-0436-y
Molecular Psychiatry, 26(3), 784-799. Nature Publishing Group
Rosato, M, Stringer, S, Gebuis, T, Paliukhovich, I, Li, K W, Posthuma, D, Sullivan, P F, Smit, A B & van Kesteren, R E 2021, ' Combined cellomics and proteomics analysis reveals shared neuronal morphology and molecular pathway phenotypes for multiple schizophrenia risk genes ', Molecular Psychiatry, vol. 26, no. 3, pp. 784-799 . https://doi.org/10.1038/s41380-019-0436-y
An enigma in studies of neuropsychiatric disorders is how to translate polygenic risk into disease biology. For schizophrenia, where > 145 significant GWAS loci have been identified and only a few genes directly implicated, addressing this issue is a
Autor:
María Soler Artigas, Anders D. Børglum, Josep Antoni Ramos-Quiroga, Benjamin M. Neale, Iris Garcia-Martínez, Marta Ribasés, Vanesa Richarte, Paula Rovira, Mireia Pagerols, Barbara Franke, Ditte Demontis, Miguel Casas, Cristina Sánchez-Mora, Jacqueline M. Vink, Stephen V. Faraone, Sven Stringer
Publikováno v:
Molecular Psychiatry, 26, 3663
ADHD Group of the Psychiatric Genomics Consortium, International Cannabis Consortium 2021, ' Correction to : Attention-deficit/hyperactivity disorder and lifetime cannabis use: genetic overlap and causality ', Molecular Psychiatry, vol. 26, no. 7, pp. 3663 . https://doi.org/10.1038/s41380-021-01049-6
Molecular Psychiatry, 26, 7, pp. 3663
ADHD Group of the Psychiatric Genomics Consortium, International Cannabis Consortium 2021, ' Correction to : Attention-deficit/hyperactivity disorder and lifetime cannabis use: genetic overlap and causality ', Molecular Psychiatry, vol. 26, no. 7, pp. 3663 . https://doi.org/10.1038/s41380-021-01049-6
Molecular Psychiatry, 26, 7, pp. 3663
A Correction to this paper has been published: https://doi.org/10.1038/s41380-021-01049-6.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0f2384479c5f62c5990ceba8fde546b
http://hdl.handle.net/2066/230713
http://hdl.handle.net/2066/230713
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e68913 (2013)
For most complex traits, results from genome-wide association studies show that the proportion of the phenotypic variance attributable to the additive effects of individual SNPs, that is, the heritability explained by the SNPs, is substantially less
Externí odkaz:
https://doaj.org/article/84345986f3824d699195f01655d997ab
Autor:
Alzheimer’s Disease Neuroimaging Initiative, Lianne M. Reus, Betty M. Tijms, Pieter Jelle Visser, Charlotte E. Teunissen, Yolande A.L. Pijnenburg, Danielle Posthuma, Sven Stringer, Philip Scheltens
Publikováno v:
Neurobiology of Aging, 93, 144.e1-144.e15. Elsevier Inc.
Alzheimer's Disease Neuroimaging Initiative 2020, ' Degree of genetic liability for Alzheimer's disease associated with specific proteomic profiles in cerebrospinal fluid ', Neurobiology of Aging, vol. 93, pp. 144.e1-144.e15 . https://doi.org/10.1016/j.neurobiolaging.2020.03.012
Alzheimer's Disease Neuroimaging Initiative 2020, ' Degree of genetic liability for Alzheimer's disease associated with specific proteomic profiles in cerebrospinal fluid ', Neurobiology of Aging, vol. 93, pp. 144.e1-144.e15 . https://doi.org/10.1016/j.neurobiolaging.2020.03.012, https://doi.org/10.1016/j.neurobiolaging.2020.03.012
Alzheimer's Disease Neuroimaging Initiative 2020, ' Degree of genetic liability for Alzheimer's disease associated with specific proteomic profiles in cerebrospinal fluid ', Neurobiology of Aging, vol. 93, pp. 144.e1-144.e15 . https://doi.org/10.1016/j.neurobiolaging.2020.03.012
Alzheimer's Disease Neuroimaging Initiative 2020, ' Degree of genetic liability for Alzheimer's disease associated with specific proteomic profiles in cerebrospinal fluid ', Neurobiology of Aging, vol. 93, pp. 144.e1-144.e15 . https://doi.org/10.1016/j.neurobiolaging.2020.03.012, https://doi.org/10.1016/j.neurobiolaging.2020.03.012
Genetic factors play a major role in Alzheimer's disease (AD) pathology, but biological mechanisms through which these factors contribute to AD remain elusive. Using a cerebrospinal fluid (CSF) proteomic approach, we examined associations between pol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d36b6088cdd604ef85053437fc50139
https://research.vumc.nl/en/publications/89fdb29c-986a-4662-837e-61b1f1a83c9c
https://research.vumc.nl/en/publications/89fdb29c-986a-4662-837e-61b1f1a83c9c
Autor:
Dan Rujescu, Vidar M. Steen, Eva Krapohl, Aarno Palotie, Elisabeth Widen, Ingrid Melle, Patrick Sullivan, Katrina L. Grasby, Stephan Ripke, Anke R. Hammerschlag, Christiaan de Leeuw, Panos Bitsios, Nikos C. Stefanis, Tonya White, Gail Davies, Ahmad R. Hariri, Philip R. Jansen, Peter B. Barr, John M. Starr, Max Lam, Ian J. Deary, Sara Hägg, Dimitrios Avramopoulos, Bettina Konte, Anil K. Malhotra, Delilah Zabaneh, Kjetil Sundet, Tinca J. C. Polderman, Ornit Chiba-Falek, Jakob Kaminski, Danielle M. Dick, Andrea Christoforou, Jin Yu, Gunter Schumann, Matthew A. Scult, Anna C. Need, Jens Hjerling-Leffler, Gonçalo R. Abecasis, Kenneth S. Kendler, Todd Lencz, Dwight Dickinson, Bradley T. Webb, Elizabeth T. Cirulli, Stephanie Le Hellard, Gerome Breen, Astri J. Lundervold, Hannah Young, Erin Burke Quinlan, William Ollier, Nikolaos Smyrnis, Emily Drabant Conley, Danielle Posthuma, Sten Linnarsson, Aristotle N. Voineskos, Edythe D. London, Pamela DeRosse, Russell A. Poldrack, Jonathan R. I. Coleman, Jeanne E. Savage, Sarah E. Medland, Ana B. Muñoz-Manchado, Richard E. Straub, Robert Plomin, Ida K. Karlsson, Nathan G. Skene, Dan E. Arking, Birgit Debrabant, Joey W. Trampush, Matthew C. Keller, Mats Nagel, Gary Donohoe, Chandra A. Reynolds, Panos Roussos, Lene Christiansen, Ivar Reinvang, Ole A. Andreassen, Antony Payton, Robert Karlsson, Margaret J. Wright, Deborah C. Koltai, Jari Lahti, Andreas Heinz, Tyrone D. Cannon, Eliza Congdon, Olav B. Smeland, Stella G. Giakoumaki, Marianne Nygaard, Julien Bryois, M. Arfan Ikram, Nancy L. Pedersen, Katri Räikkönen, Daniel R. Weinberger, Neil Pendleton, Swapnil Awasthi, Sven Stringer, Nelson A. Freimer, Aiden Corvin, Kyoko Watanabe, David C. Glahn, Henning Tiemeier, Grant W. Montgomery, Narelle K. Hansell, Robert M. Bilder, Katherine E. Burdick, Srdjan Djurovic, David C. Liewald, Sophie van der Sluis, Thomas Espeseth, Scott I. Vrieze, Fred W. Sabb, Nicholas G. Martin, Michael Gill, Emma Knowles, Derek W. Morris, Alex Hatzimanolis, Ina Giegling, Johan G. Eriksson
Publikováno v:
Nature Genetics, 50(7), 912-+. Nature Publishing Group
Savage, J E, Jansen, P R, Stringer, S, Watanabe, K, Bryois, J, De Leeuw, C A, Nagel, M, Awasthi, S, Barr, P B, Coleman, J R I, Grasby, K L, Hammerschlag, A R, Kaminski, J A, Karlsson, R, Krapohl, E, Lam, M, Nygaard, M, Reynolds, C A, Trampush, J W, Young, H, Zabaneh, D, Hägg, S, Hansell, N K, Karlsson, I K, Linnarsson, S, Montgomery, G W, Muñoz-manchado, A B, Quinlan, E B, Schumann, G, Skene, N G, Webb, B T, White, T, Arking, D E, Avramopoulos, D, Bilder, R M, Bitsios, P, Burdick, K E, Cannon, T D, Chiba-falek, O, Christoforou, A, Cirulli, E T, Congdon, E, Corvin, A, Davies, G, Deary, I J, Derosse, P, Dickinson, D, Djurovic, S, Donohoe, G, Conley, E D, Eriksson, J G, Espeseth, T, Freimer, N A, Giakoumaki, S, Giegling, I, Gill, M, Glahn, D C, Hariri, A R, Hatzimanolis, A, Keller, M C, Knowles, E, Koltai, D, Konte, B, Lahti, J, Le Hellard, S, Lencz, T, Liewald, D C, London, E, Lundervold, A J, Malhotra, A K, Melle, I, Morris, D, Need, A C, Ollier, W, Palotie, A, Payton, A, Pendleton, N, Poldrack, R A, Räikkönen, K, Reinvang, I, Roussos, P, Rujescu, D, Sabb, F W, Scult, M A, Smeland, O B, Smyrnis, N, Starr, J M, Steen, V M, Stefanis, N C, Straub, R E, Sundet, K, Tiemeier, H, Voineskos, A N, Weinberger, D R, Widen, E, Yu, J, Abecasis, G, Andreassen, O A, Breen, G, Christiansen, L, Debrabant, B, Dick, D M, Heinz, A, Hjerling-leffler, J, Ikram, M A, Kendler, K S, Martin, N G, Medland, S E, Pedersen, N L, Plomin, R, Polderman, T J C, Ripke, S, Van Der Sluis, S, Sullivan, P F, Vrieze, S I, Wright, M J & Posthuma, D 2018, ' Genome-wide association meta-analysis in 269,867 individuals identifies new genetic and functional links to intelligence ', Nature Genetics, vol. 50, pp. 912-919 . https://doi.org/10.1038/s41588-018-0152-6
Nature Genetics, 50(7), 912-919. Nature Publishing Group
Savage, J E, Jansen, P R, Stringer, S, Watanabe, K, Bryois, J, de Leeuw, C A, Nagel, M, Awasthi, S, Barr, P B, Coleman, J R I, Grasby, K L, Hammerschlag, A R, Kaminski, J A, Karlsson, R, Krapohl, E, Lam, M, Nygaard, M, Reynolds, C A, Trampush, J W, Young, H, Zabaneh, D, Hägg, S, Hansell, N K, Karlsson, I K, Linnarsson, S, Montgomery, G W, Muñoz-Manchado, A B, Quinlan, E B, Schumann, G, Skene, N G, Webb, B T, White, T, Arking, D E, Avramopoulos, D, Bilder, R M, Bitsios, P, Burdick, K E, Cannon, T D, Chiba-Falek, O, Christoforou, A, Cirulli, E T, Congdon, E, Corvin, A, Davies, G, Deary, I J, DeRosse, P, Dickinson, D, Djurovic, S, Donohoe, G, Conley, E D, Eriksson, J G, Espeseth, T, Freimer, N A, Giakoumaki, S, Giegling, I, Gill, M, Glahn, D C, Hariri, A R, Hatzimanolis, A, Keller, M C, Knowles, E, Koltai, D, Konte, B, Lahti, J, Le Hellard, S, Lencz, T, Liewald, D C, London, E, Lundervold, A J, Malhotra, A K, Melle, I, Morris, D, Need, A C, Ollier, W, Palotie, A, Payton, A, Pendleton, N, Poldrack, R A, Räikkönen, K, Reinvang, I, Roussos, P, Rujescu, D, Sabb, F W, Scult, M A, Smeland, O B, Smyrnis, N, Starr, J M, Steen, V M, Stefanis, N C, Straub, R E, Sundet, K, Tiemeier, H, Voineskos, A N, Weinberger, D R, Widen, E, Yu, J, Abecasis, G, Andreassen, O A, Breen, G, Christiansen, L, Debrabant, B, Dick, D M, Heinz, A, Hjerling-Leffler, J, Ikram, M A, Kendler, K S, Martin, N G, Medland, S E, Pedersen, N L, Plomin, R, Polderman, T J C, Ripke, S, van der Sluis, S, Sullivan, P F, Vrieze, S I, Wright, M J & Posthuma, D 2018, ' Genome-wide association meta-analysis in 269,867 individuals identifies new genetic and functional links to intelligence ', Nature Genetics, vol. 50, no. 7, 0, pp. 912-919 . https://doi.org/10.1038/s41588-018-0152-6
Savage, J E, Jansen, P R, Stringer, S, Watanabe, K, Bryois, J, de Leeuw, C A, Nagel, M, Awasthi, S, Barr, P B, Coleman, J R I, Grasby, K L, Hammerschlag, A R, Kaminski, J A, Karlsson, R, Krapohl, E, Lam, M, Nygaard, M, Reynolds, C A, Trampush, J W, Young, H, Zabaneh, D, Hägg, S, Hansell, N K, Karlsson, I K, Linnarsson, S, Montgomery, G W, Muñoz-Manchado, A B, Quinlan, E B, Schumann, G, Skene, N G, Webb, B T, White, T, Arking, D E, Avramopoulos, D, Bilder, R M, Bitsios, P, Burdick, K E, Cannon, T D, Chiba-Falek, O, Christoforou, A, Cirulli, E T, Congdon, E, Corvin, A, Davies, G, Deary, I J, DeRosse, P, Dickinson, D, Djurovic, S, Donohoe, G, Conley, E D, Eriksson, J G, Espeseth, T, Freimer, N A, Giakoumaki, S, Giegling, I, Gill, M, Glahn, D C, Hariri, A R, Hatzimanolis, A, Keller, M C, Knowles, E, Koltai, D, Konte, B, Lahti, J, Le Hellard, S, Lencz, T, Liewald, D C, London, E, Lundervold, A J, Malhotra, A K, Melle, I, Morris, D, Need, A C, Ollier, W, Palotie, A, Payton, A, Pendleton, N, Poldrack, R A, Räikkönen, K, Reinvang, I, Roussos, P, Rujescu, D, Sabb, F W, Scult, M A, Smeland, O B, Smyrnis, N, Starr, J M, Steen, V M, Stefanis, N C, Straub, R E, Sundet, K, Tiemeier, H, Voineskos, A N, Weinberger, D R, Widen, E, Yu, J, Abecasis, G, Andreassen, O A, Breen, G, Christiansen, L, Debrabant, B, Dick, D M, Heinz, A, Hjerling-Leffler, J, Ikram, M A, Kendler, K S, Martin, N G, Medland, S E, Pedersen, N L, Plomin, R, Polderman, T J C, Ripke, S, van der Sluis, S, Sullivan, P F, Vrieze, S I, Wright, M J & Posthuma, D 2018, ' Genome-wide association meta-analysis in 269,867 individuals identifies new genetic and functional links to intelligence ', Nature Genetics, vol. 50, no. 7, pp. 912-919 . https://doi.org/10.1038/s41588-018-0152-6
Savage, J E, Jansen, P R, Stringer, S, Watanabe, K, Bryois, J, de Leeuw, C A, Nagel, M, Awasthi, S, Barr, P B, Coleman, J R I, Grasby, K L, Hammerschlag, A R, Kaminski, J A, Karlsson, R, Krapohl, E, Lam, M, Nygaard, M, Reynolds, C A, Trampush, J W, Young, H, Zabaneh, D, Hägg, S, Hansell, N K, Karlsson, I K, Linnarsson, S, Montgomery, G W, Muñoz-Manchado, A B, Quinlan, E B, Schumann, G, Skene, N G, Webb, B T, White, T, Arking, D E, Avramopoulos, D, Bilder, R M, Bitsios, P, Burdick, K E, Cannon, T D, Chiba-Falek, O, Christoforou, A, Cirulli, E T, Congdon, E, Corvin, A, Davies, G, Deary, I J, DeRosse, P, Dickinson, D, Djurovic, S, Christiansen, L & Debrabant, B 2018, ' Genome-wide association meta-analysis in 269,867 individuals identifies new genetic and functional links to intelligence ', Nature Genetics, vol. 50, no. 7, pp. 912–919 . https://doi.org/10.1038/s41588-018-0152-6
Savage, J E, Jansen, P R, Stringer, S, Watanabe, K, Bryois, J, De Leeuw, C A, Nagel, M, Awasthi, S, Barr, P B, Coleman, J R I, Grasby, K L, Hammerschlag, A R, Kaminski, J A, Karlsson, R, Krapohl, E, Lam, M, Nygaard, M, Reynolds, C A, Trampush, J W, Young, H, Zabaneh, D, Hägg, S, Hansell, N K, Karlsson, I K, Linnarsson, S, Montgomery, G W, Muñoz-Manchado, A B, Quinlan, E B, Schumann, G, Skene, N G, Webb, B T, White, T, Arking, D E, Avramopoulos, D, Bilder, R M, Bitsios, P, Burdick, K E, Cannon, T D, Chiba-Falek, O, Christoforou, A, Cirulli, E T, Congdon, E, Corvin, A, Davies, G, Deary, I J, Derosse, P, Dickinson, D, Djurovic, S, Donohoe, G, Conley, E D, Eriksson, J G, Espeseth, T, Freimer, N A, Giakoumaki, S, Giegling, I, Gill, M, Glahn, D C, Hariri, A R, Hatzimanolis, A, Keller, M C, Knowles, E, Koltai, D, Konte, B, Lahti, J, Le Hellard, S, Lencz, T, Liewald, D C, London, E, Lundervold, A J, Malhotra, A K, Melle, I, Morris, D, Need, A C, Ollier, W, Palotie, A, Payton, A, Pendleton, N, Poldrack, R A, Räikkönen, K, Reinvang, I, Roussos, P, Rujescu, D, Sabb, F W, Scult, M A, Smeland, O B, Smyrnis, N, Starr, J M, Steen, V M, Stefanis, N C, Straub, R E, Sundet, K, Tiemeier, H, Voineskos, A N, Weinberger, D R, Widen, E, Yu, J, Abecasis, G, Andreassen, O A, Breen, G, Christiansen, L, Debrabant, B, Dick, D M, Heinz, A, Hjerling-Leffler, J, Ikram, M A, Kendler, K S, Martin, N G, Medland, S E, Pedersen, N L, Plomin, R, Polderman, T J C, Ripke, S, Van Der Sluis, S, Sullivan, P F, Vrieze, S I, Wright, M J & Posthuma, D 2018, ' Genome-wide association meta-analysis in 269,867 individuals identifies new genetic and functional links to intelligence ', Nature Genetics, vol. 50, no. 7, pp. 912-919 . https://doi.org/10.1038/s41588-018-0152-6
Savage, J E, Jansen, P R, Stringer, S, Watanabe, K, Bryois, J, De Leeuw, C A, Nagel, M, Awasthi, S, Barr, P B, Coleman, J R I, Grasby, K L, Hammerschlag, A R, Kaminski, J A, Karlsson, R, Krapohl, E, Lam, M, Nygaard, M, Reynolds, C A, Trampush, J W, Young, H, Zabaneh, D, Hägg, S, Hansell, N K, Karlsson, I K, Linnarsson, S, Montgomery, G W, Muñoz-manchado, A B, Quinlan, E B, Schumann, G, Skene, N G, Webb, B T, White, T, Arking, D E, Avramopoulos, D, Bilder, R M, Bitsios, P, Burdick, K E, Cannon, T D, Chiba-falek, O, Christoforou, A, Cirulli, E T, Congdon, E, Corvin, A, Davies, G, Deary, I J, Derosse, P, Dickinson, D, Djurovic, S, Donohoe, G, Conley, E D, Eriksson, J G, Espeseth, T, Freimer, N A, Giakoumaki, S, Giegling, I, Gill, M, Glahn, D C, Hariri, A R, Hatzimanolis, A, Keller, M C, Knowles, E, Koltai, D, Konte, B, Lahti, J, Le Hellard, S, Lencz, T, Liewald, D C, London, E, Lundervold, A J, Malhotra, A K, Melle, I, Morris, D, Need, A C, Ollier, W, Palotie, A, Payton, A, Pendleton, N, Poldrack, R A, Räikkönen, K, Reinvang, I, Roussos, P, Rujescu, D, Sabb, F W, Scult, M A, Smeland, O B, Smyrnis, N, Starr, J M, Steen, V M, Stefanis, N C, Straub, R E, Sundet, K, Tiemeier, H, Voineskos, A N, Weinberger, D R, Widen, E, Yu, J, Abecasis, G, Andreassen, O A, Breen, G, Christiansen, L, Debrabant, B, Dick, D M, Heinz, A, Hjerling-leffler, J, Ikram, M A, Kendler, K S, Martin, N G, Medland, S E, Pedersen, N L, Plomin, R, Polderman, T J C, Ripke, S, Van Der Sluis, S, Sullivan, P F, Vrieze, S I, Wright, M J & Posthuma, D 2018, ' Genome-wide association meta-analysis in 269,867 individuals identifies new genetic and functional links to intelligence ', Nature Genetics, vol. 50, pp. 912-919 . https://doi.org/10.1038/s41588-018-0152-6
Nature Genetics, 50(7), 912-919. Nature Publishing Group
Savage, J E, Jansen, P R, Stringer, S, Watanabe, K, Bryois, J, de Leeuw, C A, Nagel, M, Awasthi, S, Barr, P B, Coleman, J R I, Grasby, K L, Hammerschlag, A R, Kaminski, J A, Karlsson, R, Krapohl, E, Lam, M, Nygaard, M, Reynolds, C A, Trampush, J W, Young, H, Zabaneh, D, Hägg, S, Hansell, N K, Karlsson, I K, Linnarsson, S, Montgomery, G W, Muñoz-Manchado, A B, Quinlan, E B, Schumann, G, Skene, N G, Webb, B T, White, T, Arking, D E, Avramopoulos, D, Bilder, R M, Bitsios, P, Burdick, K E, Cannon, T D, Chiba-Falek, O, Christoforou, A, Cirulli, E T, Congdon, E, Corvin, A, Davies, G, Deary, I J, DeRosse, P, Dickinson, D, Djurovic, S, Donohoe, G, Conley, E D, Eriksson, J G, Espeseth, T, Freimer, N A, Giakoumaki, S, Giegling, I, Gill, M, Glahn, D C, Hariri, A R, Hatzimanolis, A, Keller, M C, Knowles, E, Koltai, D, Konte, B, Lahti, J, Le Hellard, S, Lencz, T, Liewald, D C, London, E, Lundervold, A J, Malhotra, A K, Melle, I, Morris, D, Need, A C, Ollier, W, Palotie, A, Payton, A, Pendleton, N, Poldrack, R A, Räikkönen, K, Reinvang, I, Roussos, P, Rujescu, D, Sabb, F W, Scult, M A, Smeland, O B, Smyrnis, N, Starr, J M, Steen, V M, Stefanis, N C, Straub, R E, Sundet, K, Tiemeier, H, Voineskos, A N, Weinberger, D R, Widen, E, Yu, J, Abecasis, G, Andreassen, O A, Breen, G, Christiansen, L, Debrabant, B, Dick, D M, Heinz, A, Hjerling-Leffler, J, Ikram, M A, Kendler, K S, Martin, N G, Medland, S E, Pedersen, N L, Plomin, R, Polderman, T J C, Ripke, S, van der Sluis, S, Sullivan, P F, Vrieze, S I, Wright, M J & Posthuma, D 2018, ' Genome-wide association meta-analysis in 269,867 individuals identifies new genetic and functional links to intelligence ', Nature Genetics, vol. 50, no. 7, 0, pp. 912-919 . https://doi.org/10.1038/s41588-018-0152-6
Savage, J E, Jansen, P R, Stringer, S, Watanabe, K, Bryois, J, de Leeuw, C A, Nagel, M, Awasthi, S, Barr, P B, Coleman, J R I, Grasby, K L, Hammerschlag, A R, Kaminski, J A, Karlsson, R, Krapohl, E, Lam, M, Nygaard, M, Reynolds, C A, Trampush, J W, Young, H, Zabaneh, D, Hägg, S, Hansell, N K, Karlsson, I K, Linnarsson, S, Montgomery, G W, Muñoz-Manchado, A B, Quinlan, E B, Schumann, G, Skene, N G, Webb, B T, White, T, Arking, D E, Avramopoulos, D, Bilder, R M, Bitsios, P, Burdick, K E, Cannon, T D, Chiba-Falek, O, Christoforou, A, Cirulli, E T, Congdon, E, Corvin, A, Davies, G, Deary, I J, DeRosse, P, Dickinson, D, Djurovic, S, Donohoe, G, Conley, E D, Eriksson, J G, Espeseth, T, Freimer, N A, Giakoumaki, S, Giegling, I, Gill, M, Glahn, D C, Hariri, A R, Hatzimanolis, A, Keller, M C, Knowles, E, Koltai, D, Konte, B, Lahti, J, Le Hellard, S, Lencz, T, Liewald, D C, London, E, Lundervold, A J, Malhotra, A K, Melle, I, Morris, D, Need, A C, Ollier, W, Palotie, A, Payton, A, Pendleton, N, Poldrack, R A, Räikkönen, K, Reinvang, I, Roussos, P, Rujescu, D, Sabb, F W, Scult, M A, Smeland, O B, Smyrnis, N, Starr, J M, Steen, V M, Stefanis, N C, Straub, R E, Sundet, K, Tiemeier, H, Voineskos, A N, Weinberger, D R, Widen, E, Yu, J, Abecasis, G, Andreassen, O A, Breen, G, Christiansen, L, Debrabant, B, Dick, D M, Heinz, A, Hjerling-Leffler, J, Ikram, M A, Kendler, K S, Martin, N G, Medland, S E, Pedersen, N L, Plomin, R, Polderman, T J C, Ripke, S, van der Sluis, S, Sullivan, P F, Vrieze, S I, Wright, M J & Posthuma, D 2018, ' Genome-wide association meta-analysis in 269,867 individuals identifies new genetic and functional links to intelligence ', Nature Genetics, vol. 50, no. 7, pp. 912-919 . https://doi.org/10.1038/s41588-018-0152-6
Savage, J E, Jansen, P R, Stringer, S, Watanabe, K, Bryois, J, de Leeuw, C A, Nagel, M, Awasthi, S, Barr, P B, Coleman, J R I, Grasby, K L, Hammerschlag, A R, Kaminski, J A, Karlsson, R, Krapohl, E, Lam, M, Nygaard, M, Reynolds, C A, Trampush, J W, Young, H, Zabaneh, D, Hägg, S, Hansell, N K, Karlsson, I K, Linnarsson, S, Montgomery, G W, Muñoz-Manchado, A B, Quinlan, E B, Schumann, G, Skene, N G, Webb, B T, White, T, Arking, D E, Avramopoulos, D, Bilder, R M, Bitsios, P, Burdick, K E, Cannon, T D, Chiba-Falek, O, Christoforou, A, Cirulli, E T, Congdon, E, Corvin, A, Davies, G, Deary, I J, DeRosse, P, Dickinson, D, Djurovic, S, Christiansen, L & Debrabant, B 2018, ' Genome-wide association meta-analysis in 269,867 individuals identifies new genetic and functional links to intelligence ', Nature Genetics, vol. 50, no. 7, pp. 912–919 . https://doi.org/10.1038/s41588-018-0152-6
Savage, J E, Jansen, P R, Stringer, S, Watanabe, K, Bryois, J, De Leeuw, C A, Nagel, M, Awasthi, S, Barr, P B, Coleman, J R I, Grasby, K L, Hammerschlag, A R, Kaminski, J A, Karlsson, R, Krapohl, E, Lam, M, Nygaard, M, Reynolds, C A, Trampush, J W, Young, H, Zabaneh, D, Hägg, S, Hansell, N K, Karlsson, I K, Linnarsson, S, Montgomery, G W, Muñoz-Manchado, A B, Quinlan, E B, Schumann, G, Skene, N G, Webb, B T, White, T, Arking, D E, Avramopoulos, D, Bilder, R M, Bitsios, P, Burdick, K E, Cannon, T D, Chiba-Falek, O, Christoforou, A, Cirulli, E T, Congdon, E, Corvin, A, Davies, G, Deary, I J, Derosse, P, Dickinson, D, Djurovic, S, Donohoe, G, Conley, E D, Eriksson, J G, Espeseth, T, Freimer, N A, Giakoumaki, S, Giegling, I, Gill, M, Glahn, D C, Hariri, A R, Hatzimanolis, A, Keller, M C, Knowles, E, Koltai, D, Konte, B, Lahti, J, Le Hellard, S, Lencz, T, Liewald, D C, London, E, Lundervold, A J, Malhotra, A K, Melle, I, Morris, D, Need, A C, Ollier, W, Palotie, A, Payton, A, Pendleton, N, Poldrack, R A, Räikkönen, K, Reinvang, I, Roussos, P, Rujescu, D, Sabb, F W, Scult, M A, Smeland, O B, Smyrnis, N, Starr, J M, Steen, V M, Stefanis, N C, Straub, R E, Sundet, K, Tiemeier, H, Voineskos, A N, Weinberger, D R, Widen, E, Yu, J, Abecasis, G, Andreassen, O A, Breen, G, Christiansen, L, Debrabant, B, Dick, D M, Heinz, A, Hjerling-Leffler, J, Ikram, M A, Kendler, K S, Martin, N G, Medland, S E, Pedersen, N L, Plomin, R, Polderman, T J C, Ripke, S, Van Der Sluis, S, Sullivan, P F, Vrieze, S I, Wright, M J & Posthuma, D 2018, ' Genome-wide association meta-analysis in 269,867 individuals identifies new genetic and functional links to intelligence ', Nature Genetics, vol. 50, no. 7, pp. 912-919 . https://doi.org/10.1038/s41588-018-0152-6
Intelligence is highly heritable 1 and a major determinant of human health and well-being 2 . Recent genome-wide meta-analyses have identified 24 genomic loci linked to variation in intelligence 3-7 , but much about its genetic underpinnings remains
Publikováno v:
PLoS ONE, Vol 6, Iss 11, p e27964 (2011)
Complex diseases are often highly heritable. However, for many complex traits only a small proportion of the heritability can be explained by observed genetic variants in traditional genome-wide association (GWA) studies. Moreover, for some of those
Externí odkaz:
https://doaj.org/article/05d4391e243f4e0299ae9ca865085982