Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Sven Rothemund"'
Autor:
Brianda L. Santini, Margrethe Gaardløs, Dariusz Wyrzykowski, Sven Rothemund, Anja Penk, Martin Zacharias, Sergey A. Samsonov
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 23, Iss , Pp 2985-2994 (2024)
Cyclic peptides present a robust platform for drug design, offering high specificity and stability due to their conformationally constrained structures. In this study, we introduce an updated version of the Cyclic Peptide Matching program (cPEPmatch)
Externí odkaz:
https://doaj.org/article/35f5e31773204f40aabdbcb950c9b903
Publikováno v:
Biomedicines, Vol 10, Iss 7, p 1512 (2022)
We here report a novel strategy to control the bioavailability of the fibrillizing parathyroid hormone (PTH)-derived peptides, where the concentration of the bioactive form is controlled by an reversible, photoswitchable peptide. PTH1–84, a human h
Externí odkaz:
https://doaj.org/article/3c220cfd67fd4799b7fe42b86f401081
Autor:
Paula Bollmann, Franziska Werner, Marko Jaron, Tom A. Bruns, Hartmut Wache, Jochen Runte, Peter Boknik, Uwe Kirchhefer, Frank U. Müller, Igor B. Buchwalow, Sven Rothemund, Joachim Neumann, Ulrich Gergs
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2021)
As part of our ongoing studies on the potential pathophysiological role of serine/threonine phosphatases (PP) in the mammalian heart, we have generated mice with cardiac-specific overexpression of PP2Cβ (PP2C-TG) and compared them with littermate wi
Externí odkaz:
https://doaj.org/article/b021743755d641a393a09eb53a4cce6f
Autor:
Anna Peters, Petra Krumbholz, Elisabeth Jäger, Anna Heintz-Buschart, Mehmet Volkan Çakir, Sven Rothemund, Alexander Gaudl, Uta Ceglarek, Torsten Schöneberg, Claudia Stäubert
Publikováno v:
PLoS Genetics, Vol 15, Iss 7, p e1008283 (2019)
[This corrects the article DOI: 10.1371/journal.pgen.1008145.].
Externí odkaz:
https://doaj.org/article/d5d1c45a492a4e87870341bd06bff8b4
Autor:
Anna Peters, Petra Krumbholz, Elisabeth Jäger, Anna Heintz-Buschart, Mehmet Volkan Çakir, Sven Rothemund, Alexander Gaudl, Uta Ceglarek, Torsten Schöneberg, Claudia Stäubert
Publikováno v:
PLoS Genetics, Vol 15, Iss 5, p e1008145 (2019)
The interplay of microbiota and the human host is physiologically crucial in health and diseases. The beneficial effects of lactic acid bacteria (LAB), permanently colonizing the human intestine or transiently obtained from food, have been extensivel
Externí odkaz:
https://doaj.org/article/ce392e97ce304b04b60ec081d3701009
Autor:
Juliane Röthe, Doreen Thor, Jana Winkler, Alexander B. Knierim, Claudia Binder, Sandra Huth, Robert Kraft, Sven Rothemund, Torsten Schöneberg, Simone Prömel
Publikováno v:
Cell Reports, Vol 26, Iss 6, Pp 1573-1584.e5 (2019)
Summary: Insulin secretion from pancreatic β cells is a highly complex and tightly regulated process. Its dysregulation is one characteristic of type 2 diabetes, and thus, an in-depth understanding of the mechanisms controlling insulin secretion is
Externí odkaz:
https://doaj.org/article/817373dca9cf4a059992f6c63eedf44f
Autor:
Ines Liebscher, Julia Schön, Sarah C. Petersen, Liane Fischer, Nina Auerbach, Lilian Marie Demberg, Amit Mogha, Maxi Cöster, Kay-Uwe Simon, Sven Rothemund, Kelly R. Monk, Torsten Schöneberg
Publikováno v:
Cell Reports, Vol 9, Iss 6, Pp 2018-2026 (2014)
Adhesion G protein-coupled receptors (aGPCRs) comprise the second largest yet least studied class of the GPCR superfamily. aGPCRs are involved in many developmental processes and immune and synaptic functions, but the mode of their signal transductio
Externí odkaz:
https://doaj.org/article/3f3477fcd9df49e4bfc98d591c8d863e
Autor:
Nicole Scholz, Chonglin Guan, Matthias Nieberler, Alexander Grotemeyer, Isabella Maiellaro, Shiqiang Gao, Sebastian Beck, Matthias Pawlak, Markus Sauer, Esther Asan, Sven Rothemund, Jana Winkler, Simone Prömel, Georg Nagel, Tobias Langenhan, Robert J Kittel
Publikováno v:
eLife, Vol 6 (2017)
Adhesion-type G protein-coupled receptors (aGPCRs), a large molecule family with over 30 members in humans, operate in organ development, brain function and govern immunological responses. Correspondingly, this receptor family is linked to a multitud
Externí odkaz:
https://doaj.org/article/e820c749773040feb7f732624cecd87d
Autor:
Antje Müller, Jana Winkler, Franziska Fiedler, Tania Sastradihardja, Claudia Binder, Ralf Schnabel, Jana Kungel, Sven Rothemund, Christian Hennig, Torsten Schöneberg, Simone Prömel
Publikováno v:
PLoS Genetics, Vol 11, Iss 10, p e1005624 (2015)
Orientation of spindles and cell division planes during development of many species ensures that correct cell-cell contacts are established, which is vital for proper tissue formation. This is a tightly regulated process involving a complex interplay
Externí odkaz:
https://doaj.org/article/2584e66f15094cecb42d052e3125729f
Autor:
Ines Liebscher, Julia Schön, Sarah C. Petersen, Liane Fischer, Nina Auerbach, Lilian Marie Demberg, Amit Mogha, Maxi Cöster, Kay-Uwe Simon, Sven Rothemund, Kelly R. Monk, Torsten Schöneberg
Publikováno v:
Cell Reports, Vol 10, Iss 6, p 1021 (2015)
Externí odkaz:
https://doaj.org/article/a2fe3c9d751144c491109893c95c8536