Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Sven P. Wichert"'
Autor:
Julia Kasprzak, Timothy Goering, Karin Berger-Thürmel, Vanessa Kratzer, Wuthichai Prompinit, Sven P. Wichert, Simon Leutner, Norbert Langermann, Michael von Bergwelt-Baildon, Volker Heinemann, Hana Algül, Martin Zünkeler, Daniel Nasseh
Publikováno v:
Digital Health, Vol 10 (2024)
Objectives The treatment of rare tumors often necessitates the involvement of highly specialized teams, typically based in larger medical centers or university hospitals, which are often lacking in rural areas. The German TARGET (the Trans-sectoral P
Externí odkaz:
https://doaj.org/article/8edf269f97ab4f56acc84ddeb931d70b
Autor:
Lukša Popović, Jan P. Wintgens, Yuxin Wu, Ben Brankatschk, Sascha Menninger, Carsten Degenhart, Niels Jensen, Sven P. Wichert, Bert Klebl, Moritz J. Rossner, Michael C. Wehr
Publikováno v:
iScience, Vol 27, Iss 2, Pp 108839- (2024)
Summary: ERBB receptor tyrosine kinases are involved in development and diseases like cancer, cardiovascular, neurodevelopmental, and mental disorders. Although existing drugs target ERBB receptors, the next generation of drugs requires enhanced sele
Externí odkaz:
https://doaj.org/article/ff5d053643f145278c5b251d0afc7838
Autor:
Janos L. Kalman, Gerrit Burkhardt, Kristina Adorjan, Barbara B. Barton, Sylvia De Jonge, Daniela Eser-Valeri, Christine M. Falter-Wagner, Urs Heilbronner, Andrea Jobst, Daniel Keeser, Christian Koenig, Gabi Koller, Nikolaos Koutsouleris, Carolin Kurz, Dominic Landgraf, Katharina Merz, Richard Musil, Afton M. Nelson, Frank Padberg, Sergi Papiol, Oliver Pogarell, Robert Perneczky, Florian Raabe, Matthias A. Reinhard, Almut Richter, Tobias Rüther, Maria Susanne Simon, Andrea Schmitt, Lenka Slapakova, Nanja Scheel, Cornelius Schüle, Elias Wagner, Sven P. Wichert, Peter Zill, Peter Falkai, Thomas G. Schulze, Eva Christina Schulte
Publikováno v:
Frontiers in Psychiatry, Vol 13 (2022)
Translational research on complex, multifactorial mental health disorders, such as bipolar disorder, major depressive disorder, schizophrenia, and substance use disorders requires databases with large-scale, harmonized, and integrated real-world and
Externí odkaz:
https://doaj.org/article/39d7c1a21d9c4d07a14ea8ca5d65f947
Autor:
Sabine Herold, Prateek Kumar, Sven P Wichert, Benedikt Kretzschmar, Mathias Bähr, Moritz J Rossner, Katharina Hein
Publikováno v:
PLoS ONE, Vol 10, Iss 10, p e0138852 (2015)
Multiple Sclerosis (MS) is a chronic autoimmune inflammatory disease of the central nervous system (CNS). Histopathological and radiological analysis revealed that neurodegeneration occurs early in the disease course. However, the pathological mechan
Externí odkaz:
https://doaj.org/article/059cbfb7688a4754bcef7f6da3440915
Publikováno v:
Cellular and Molecular Life Sciences
Receptor tyrosine kinases (RTKs) play key roles in various aspects of cell biology, including cell-to-cell communication, proliferation and differentiation, survival, and tissue homeostasis, and have been implicated in various diseases including canc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a028731e37f4c04fff5c50485e740bc0
http://europepmc.org/articles/PMC6675780
http://europepmc.org/articles/PMC6675780
Autor:
Paul C Baier, Magdalena M Brzózka, Ali Shahmoradi, Lisa Reinecke, Christina Kroos, Sven P Wichert, Henrik Oster, Michael C Wehr, Reshma Taneja, Johannes Hirrlinger, Moritz J Rossner
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e110310 (2014)
Increasing evidence suggests that clock genes may be implicated in a spectrum of psychiatric diseases, including sleep and mood related disorders as well as schizophrenia. The bHLH transcription factors SHARP1/DEC2/BHLHE41 and SHARP2/DEC1/BHLHE40 are
Externí odkaz:
https://doaj.org/article/e2c75b49f97e486ab971d0167c3a0e2b
Autor:
Moritz J Rossner, Henrik Oster, Sven P Wichert, Lisa Reinecke, Michael C Wehr, Johannes Reinecke, Gregor Eichele, Reshma Taneja, Klaus-Armin Nave
Publikováno v:
PLoS ONE, Vol 3, Iss 7, p e2762 (2008)
BackgroundThe circadian system provides the basis to anticipate and cope with daily recurrent challenges to maintain the organisms' homeostasis. De-synchronization of circadian feedback oscillators in humans causes 'jet lag', likely contributes to sl
Externí odkaz:
https://doaj.org/article/86559e37fc204688aaed8a707e16e04e
Autor:
Sergi Papiol, Sven P. Wichert, Michael C. Wehr, Ben Brankatschk, Moritz J. Rossner, Alexander Herholt, Nirmal Kannaiyan
Publikováno v:
Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-14 (2018)
Scientific Reports, Vol 8, Iss 1, Pp 1-14 (2018)
Neuronal signal transduction shapes brain function and malfunction may cause mental disorders. Despite the existence of functional genomics screens for proliferation and toxicity, neuronal signalling has been difficult to address so far. To overcome
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dd6ab43afdaf7e0426f6b900f8a8bb5
https://doi.org/10.1038/s41598-018-36008-9
https://doi.org/10.1038/s41598-018-36008-9
Publikováno v:
Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)
Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)
G protein-coupled receptors (GPCRs) are the largest class of cell surface receptors and are implicated in the physiological regulation of many biological processes. The high diversity of GPCRs and their physiological functions make them primary targe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::596acc35af4491970802a00642920753
https://doi.org/10.1038/s41598-018-26401-9
https://doi.org/10.1038/s41598-018-26401-9
Autor:
Peter Falkai, Mykola Kravchenko, Jan P. Wintgens, Sven P. Wichert, Mingyue Zhang, Tilmann Unterbarnscheidt, Weiqi Zhang, Michael C. Wehr, Maria Clara Soto-Bernardini, Moritz J. Rossner, Wilko Hinrichs, Sergi Papiol, Magdalena M. Brzózka, Klaus-Armin Nave, Markus H. Schwab, Alexander Herholt
Publikováno v:
EMBO Molecular Medicine
Embo Molecular Medicine
Embo Molecular Medicine
Enhanced NRG1‐ERBB4 signaling is a risk pathway in schizophrenia, and corresponding mouse models display several endophenotypes of the disease. Nonetheless, pathway‐directed treatment strategies with clinically applicable compounds have not been
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0bf0434597fcb5da936eb2e425e6dbe
https://pubmed.ncbi.nlm.nih.gov/28743784
https://pubmed.ncbi.nlm.nih.gov/28743784