Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Sven Mathias"'
Autor:
Joschka Bauer, Sven Mathias, Sebastian Kube, Kerstin Otte, Patrick Garidel, Martin Gamer, Michaela Blech, Simon Fischer, Anne R Karow-Zwick
Publikováno v:
mAbs, Vol 12, Iss 1 (2020)
The discovery of therapeutic monoclonal antibodies (mAbs) primarily focuses on their biological activity favoring the selection of highly potent drug candidates. These candidates, however, may have physical or chemical attributes that lead to unfavor
Externí odkaz:
https://doaj.org/article/4b709eb7b77347208fd2e1baab40e518
Autor:
Nikolas Zeh, Helga Schneider, Sven Mathias, Nadja Raab, Michael Kleemann, Sabine Schmidt-Hertel, Benjamin Weis, Silke Wissing, Nikola Strempel, René Handrick, Kerstin Otte
Publikováno v:
PLoS ONE, Vol 14, Iss 8, p e0221679 (2019)
Exosomes represent a promising delivery tool for nucleic acid-based pharmaceuticals. They are highly suitable for transporting therapeutic miRNAs to tumor cells, due to their natural membrane components. Further, exosomes are capable of effectively p
Externí odkaz:
https://doaj.org/article/dfa96773dacc49e182f77410d1b73f91
Autor:
Martin Gamer, Karlheinz Holzmann, René Handrick, Simon Fischer, Patrick Schlossbauer, Benjamin Lindner, Anna Stadermann, Nadja Raab, Kerstin Otte, Sven Mathias, Nikolas Zeh
Publikováno v:
New Biotechnology. 66:79-88
Chinese Hamster Ovary (CHO) cells are the most frequently used biopharmaceutical production hosts, although industry is presently suffering from their variable recombinant product quality, insufficient long-term stability and low productivity. Here,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f6530a41cfce4883fcfd2a4434a99ba
https://doi.org/10.1016/j.nbt.2021.10.005
https://doi.org/10.1016/j.nbt.2021.10.005
Autor:
Simon Fischer, Sven Mathias, Anna Stadermann, Shumin Yang, Valerie Schmieder, Nikolas Zeh, Nicoletta Schmidt, Patrick Richter, Sara Wright, Eike Zimmermann, Yan Ley, Julia Meer, Thomas Hartsch, Christian Bernloehr, Kerstin Otte, Harald Bradl, Martin Gamer, Patrick Schulz
Publikováno v:
Biotechnology and bioengineering. 119(3)
Chinese hamster ovary (CHO) cells are known not to express appreciable levels of the sialic acid residue N-glycolylneuraminic acid (NGNA) on monoclonal antibodies. However, we actually have identified a recombinant CHO cell line expressing an IgG wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::277d0ea870b0e07c9bedb04afb4db02d
https://pubmed.ncbi.nlm.nih.gov/34935124
https://pubmed.ncbi.nlm.nih.gov/34935124
Autor:
Theresa Buck, Jens Pfannstiel, Nikolas Zeh, Yu-Wei Shieh, Kerstin Otte, Helga Schneider, Nadja Raab, Sven Mathias, Florian Klingler
Publikováno v:
Biotechnology and bioengineeringREFERENCES. 118(8)
Chinese hamster ovary (CHO) suspension cells are the main production hosts for biopharmaceuticals. For the improvement of production processes, it is essential to understand the interaction between CHO cells and their microenvironment. While the cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c07305af0b094f4e771646de24da359
https://pubmed.ncbi.nlm.nih.gov/33951178
https://pubmed.ncbi.nlm.nih.gov/33951178
Autor:
Anne R. Karow-Zwick, Kerstin Otte, Sven Mathias, Sebastian Kube, Joschka Bauer, Martin Gamer, Patrick Garidel, Michaela Blech, Simon Fischer
Publikováno v:
mAbs
article-version (VoR) Version of Record
article-version (VoR) Version of Record
The discovery of therapeutic monoclonal antibodies (mAbs) primarily focuses on their biological activity favoring the selection of highly potent drug candidates. These candidates, however, may have physical or chemical attributes that lead to unfavor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0801ccb1c9702cd2384f349290bced8
https://doi.org/10.1080/19420862.2020.1787121
https://doi.org/10.1080/19420862.2020.1787121
Autor:
Kerstin Otte, Nikolas Zeh, Nikola Strempel, Sven Mathias, René Handrick, Nadja Raab, Sabine Schmidt-Hertel, Silke Wissing, Helga Schneider, Michael Kleemann, Benjamin Weis
Publikováno v:
PLoS ONE
PLoS ONE, Vol 14, Iss 8, p e0221679 (2019)
PLoS ONE, Vol 14, Iss 8, p e0221679 (2019)
Exosomes represent a promising delivery tool for nucleic acid-based pharmaceuticals. They are highly suitable for transporting therapeutic miRNAs to tumor cells, due to their natural membrane components. Further, exosomes are capable of effectively p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da602cd7dbec7d08bd11da8862e6c068
http://europepmc.org/articles/PMC6713437
http://europepmc.org/articles/PMC6713437
Autor:
Ingo Gorr, Patrick Schulz, Simon Fischer, Martin Gamer, René Handrick, Nikolas Zeh, Anna Wippermann, Nadja Raab, Kerstin Otte, Sven Mathias
Publikováno v:
Biotechnology and bioengineeringREFERENCES. 117(1)
Although most therapeutic monoclonal antibodies (mAbs) can routinely be produced in the multigram per litre range, some mAb candidates turn out to be difficult-to-express (DTE). In addition, the class of more complex biological formats is permanently
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1665a0a52fd0b27e13c58ceeb9248b0d
https://pubmed.ncbi.nlm.nih.gov/31631329
https://pubmed.ncbi.nlm.nih.gov/31631329
Autor:
Kerstin Alt, René Handrick, Vaibhav Jadhav, Kerstin Otte, Nicole Borth, Simon Fischer, Nadja Raab, Sven Mathias, Valerie Schmieder
Publikováno v:
Biotechnology journal. 14(5)
MicroRNAs (miRNAs) are noncoding RNAs that serve as versatile molecular engineering tools to improve production cells by overexpression or knockdown of miRNAs showing beneficial or adverse effects on cell-culture performance. The genomic knockout (KO
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58cbeae1424ff1fb57fe93a4990d90f9
https://pubmed.ncbi.nlm.nih.gov/30802343
https://pubmed.ncbi.nlm.nih.gov/30802343
Autor:
Michael Kleemann, Theresa Buck, René Handrick, Verena V. Emmerling, Matthias Hackl, Simon Fischer, Johannes Grillari, Simone Schaz, Armaz Aschrafi, Kerstin Otte, Sven Mathias
Publikováno v:
Journal of Biotechnology. 212:32-43
Functional genomics represent a valuable approach to improve culture performance of Chinese hamster ovary (CHO) cell lines for biopharmaceutical manufacturing. Recent advances in applied microRNA (miRNAs) research suggest that these small non-coding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2b9eea69c909e83a048ae511248d7de
https://doi.org/10.1016/j.jbiotec.2015.08.002
https://doi.org/10.1016/j.jbiotec.2015.08.002