Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Sven Marcel Stefan"'
Publikováno v:
Journal of Cheminformatics, Vol 16, Iss 1, Pp 1-14 (2024)
Abstract The identification, establishment, and exploration of potential pharmacological drug targets are major steps of the drug development pipeline. Target validation requires diverse chemical tools that come with a spectrum of functionality, e.g.
Externí odkaz:
https://doaj.org/article/915ee01612964edf8b8ce915d86aee8f
Publikováno v:
Scientific Data, Vol 11, Iss 1, Pp 1-14 (2024)
Abstract The identification of lead molecules and the exploration of novel pharmacological drug targets are major challenges of medical life sciences today. Genome‐wide association studies, multi-omics, and systems pharmacology steadily reveal new
Externí odkaz:
https://doaj.org/article/b76f4a1f526c490d81171551ee611e41
Autor:
Sven Marcel Stefan, Muhammad Rafehi
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Medicinal polypharmacology is one answer to the complex reality of multifactorial human diseases that are often unresponsive to single-targeted treatment. It is an admittance that intrinsic feedback mechanisms, crosstalk, and disease networks necessi
Externí odkaz:
https://doaj.org/article/201cd5c0b4d04b3395a12a4e79d40f1d
Publikováno v:
Journal of Cheminformatics, Vol 15, Iss 1, Pp 1-10 (2023)
Abstract The discovery of both distinctive lead molecules and novel drug targets is a great challenge in drug discovery, which particularly accounts for orphan diseases. Huntington’s disease (HD) is an orphan, neurodegenerative disease of which the
Externí odkaz:
https://doaj.org/article/7191e25a664a40a48b2859a1635161d9
Autor:
Sven Marcel Stefan, Muhammad Rafehi
Publikováno v:
Neural Regeneration Research, Vol 19, Iss 8, Pp 1647-1648 (2024)
Externí odkaz:
https://doaj.org/article/93eda158c3a149508ed469f086643128
Publikováno v:
Scientific Data, Vol 9, Iss 1, Pp 1-14 (2022)
Measurement(s) Influx • Efflux • Tracer • Transport velocity Technology Type(s) Fluorometry • Radioactivity • Plate reader • Flow cytometer • Tracer distribution Factor Type(s) half-maximal inhibition concentration Sample Characteristic
Externí odkaz:
https://doaj.org/article/35de399dd5c64cffabea4b11683a95a6
Autor:
Luisa Möhle, Katja Stefan, Pablo Bascuñana, Mirjam Brackhan, Thomas Brüning, Ivan Eiriz, Ahmed El Menuawy, Sylvie van Genderen, Irene Santos-García, Anna Maria Górska, María Villa, Jingyun Wu, Sven Marcel Stefan, Jens Pahnke
Publikováno v:
Biology, Vol 12, Iss 7, p 932 (2023)
Alzheimer’s disease (AD), the leading cause of dementia, is a growing health issue with very limited treatment options. To meet the need for novel therapeutics, existing drugs with additional preferred pharmacological profiles could be recruited. T
Externí odkaz:
https://doaj.org/article/b3743d71a7f84bc691a9e0438153a5e3
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 19, Iss , Pp 3269-3283 (2021)
Computer-aided pattern analysis (C@PA) was recently presented as a powerful tool to predict multitarget ABC transporter inhibitors. The backbone of this computational methodology was the statistical analysis of frequently occurring molecular features
Externí odkaz:
https://doaj.org/article/43fb7fc0071c408bbfccf6004c679a82
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 19, Iss , Pp 6490-6504 (2021)
The adenosine-triphosphate-(ATP)-binding cassette (ABC) transporter ABCA7 is a genetic risk factor for Alzheimer’s disease (AD). Defective ABCA7 promotes AD development and/or progression. Unfortunately, ABCA7 belongs to the group of ‘under-studi
Externí odkaz:
https://doaj.org/article/c222e50d710e4b9e9d540cec71d79b14
Autor:
Jens Pahnke, Pablo Bascuñana, Mirjam Brackhan, Katja Stefan, Vigneshwaran Namasivayam, Radosveta Koldamova, Jingyun Wu, Luisa Möhle, Sven Marcel Stefan
Publikováno v:
Free Neuropathology, Vol 2 (2021)
Adenosine-triphosphate-(ATP)-binding cassette (ABC) transport proteins are ubiquitously present membrane-bound efflux pumps that distribute endo- and xenobiotics across intra- and intercellular barriers. Discovered over 40 years ago, ABC transporters
Externí odkaz:
https://doaj.org/article/2a455a57340e4bdc881b25f95719c033