Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Sven Malchow"'
Autor:
Sven Malchow, Alla Korepanova, Sanjay C. Panchal, Ryan A. McClure, Kenton L. Longenecker, Wei Qiu, Hongyu Zhao, Min Cheng, Jun Guo, Kelly L. Klinge, Patricia Trusk, Steven D. Pratt, Tao Li, Matthew D. Kurnick, Lishu Duan, Alex R. Shoemaker, Sujatha M. Gopalakrishnan, Scott E. Warder, J. Brad Shotwell, Albert Lai, Chaohong Sun, Augustine T. Osuma, William N. Pappano
Publikováno v:
ACS chemical biology. 17(3)
Hematopoietic progenitor kinase 1 (HPK1) is an MAP4K family member within the Ste20-like serine/threonine branch of the kinome. HPK1 expression is limited to hematopoietic cells and has a predominant role as a negative regulator of T cell function. B
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d41ef3dd8d993a23762cf2d11769d5f5
https://pubmed.ncbi.nlm.nih.gov/35188729
https://pubmed.ncbi.nlm.nih.gov/35188729
Autor:
Peter A. Savage, Nicholas D. Socci, Saki Nishi, Daniel S. Leventhal, Victoria Lee, Sven Malchow
Publikováno v:
Immunity. 44:1102-1113
The promiscuous expression of tissue-restricted antigens in the thymus, driven in part by autoimmune regulator (Aire), is critical for the protection of peripheral tissues from autoimmune attack. Aire-dependent processes are thought to promote both c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4a6e7ca3cddff7e0c378a46bae60287
https://doi.org/10.1016/j.immuni.2016.02.009
https://doi.org/10.1016/j.immuni.2016.02.009
Autor:
Haochu Huang, Douglas E. Kline, Peter A. Savage, Julian M. Berger, Nicholas D. Socci, Donald J. Vander Griend, Sven Malchow, Saki Nishi, Daniel S. Leventhal, Victoria Lee, Dana C. Gilmore, Justin Kline
Publikováno v:
Immunity. 44:847-859
Although antigen recognition mediated by the T cell receptor (TCR) influences many facets of Foxp3(+) regulatory T (Treg) cell biology, including development and function, the cell types that present antigen to Treg cells in vivo remain largely undef
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09fa976a17f6da7f27400b8b0c89b9ea
https://doi.org/10.1016/j.immuni.2016.01.025
https://doi.org/10.1016/j.immuni.2016.01.025
Autor:
Jessica Gewiese-Rabsch, Jürgen Scheller, Kosuke Yamamoto, Stefan Rose-John, Nathalie Jänner, Wolfgang Thaiss, Christoph Garbers, Sven Malchow, Georg H. Waetzig
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1812:290-301
Neutrophil depleted mice are protected from concanavalin A-mediated hepatitis, showing that neutrophils are critical for cellular liver damage. Interleukin-6 has pro- and anti-inflammatory properties and mediates neutrophil recruitment in diseases su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3c2f24c2ee0b69c4ff088d79243b340
https://doi.org/10.1016/j.bbadis.2010.11.009
https://doi.org/10.1016/j.bbadis.2010.11.009
Autor:
Jürgen Scheller, Doreen M. Floss, Ingo Plagmann, Andrei A. Kruglov, Sven Malchow, Udo Conrad, Sergei A. Nedospasov, Markus Sack, Stefan Rose-John
Publikováno v:
Plant Biotechnology Journal. 9:22-31
Tumour necrosis factor (TNF) is a major pro-inflammatory cytokine involved in multiple inflammatory diseases. The detrimental activity of TNF can be blocked by various antagonists, and commercial therapeutics based upon this principle have been appro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::68ae42678c5dce28c0d1f0081a809495
https://doi.org/10.1111/j.1467-7652.2010.00523.x
https://doi.org/10.1111/j.1467-7652.2010.00523.x
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1802:1054-1061
Interleukin-6 (IL-6) plays an important role in liver regeneration and protection against liver damage. In addition to IL-6 classic signaling via membrane bound receptor (mIL-6R), IL-6 signaling can also be mediated by soluble IL-6R (sIL-6R) thereby
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::665a5c631d8b2cfad878f1b93ab70e25
https://doi.org/10.1016/j.bbadis.2010.07.023
https://doi.org/10.1016/j.bbadis.2010.07.023
Publikováno v:
Journal of Autoimmunity. 34:29-37
Interleukin-6 (IL-6) has been suggested to play a pivotal role in liver regeneration. IL-6 on target cells activates a receptor complex consisting of the IL-6 receptor (IL-6R) and the signal transducing receptor subunit gp130. Not all cells in the bo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e6167b951ec485aa1ecd1eb6f1a0cf8
https://doi.org/10.1016/j.jaut.2009.08.003
https://doi.org/10.1016/j.jaut.2009.08.003
Publikováno v:
Immunological reviews. 259(1)
Many tumors express antigens that can be specifically or selectively recognized by T lymphocytes, suggesting that T-cell-mediated immunity may be harnessed for the immunotherapy of cancer. However, since tumors originate from normal cells and evolve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::802f90c48e3ce08bfb7f39eb6b46b6d8
https://pubmed.ncbi.nlm.nih.gov/24712470
https://pubmed.ncbi.nlm.nih.gov/24712470
Publikováno v:
Oncoimmunology
Little is known about the relative contributions of self-specific regulatory T cells (Tregs) of thymic origin and induced Tregs generated extrathymically to the pool of tumor-infiltrating Tregs. We have recently demonstrated that thymic-derived Tregs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1d88d67f73675730afea000c4b4f051
https://pubmed.ncbi.nlm.nih.gov/24073374
https://pubmed.ncbi.nlm.nih.gov/24073374
Publikováno v:
Trends in immunology. 34(1)
Due to the critical role of Foxp3+ regulatory T cells (Tregs) in the regulation of immunity and the enrichment of Tregs within many human tumors, a number of emerging therapeutic strategies for the treatment of cancer involve the depletion or modulat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98f3a1678ad40d6f464d786efdc53a82
https://pubmed.ncbi.nlm.nih.gov/22999714
https://pubmed.ncbi.nlm.nih.gov/22999714