Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Sven Lindemann"'
Autor:
Francisco Castillo, David Ramírez, María C. Ramos, Blanca Martinez-Arribas, Elisabeth Domingo-Contreras, Thomas A. Mackenzie, Carlos Peña-Varas, Sven Lindemann, Fernando Montero, Fredderick Annang, Francisca Vicente, Olga Genilloud, Dolores González-Pacanowska, Rosario Fernandez-Godino
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
The SARS coronavirus 2 (SARS-CoV-2) epidemic remains globally active. The emergence of new variants of interest and variants of concern (VoCs), which are potentially more vaccine-resistant and less sensitive to existing treatments, is evident due to
Externí odkaz:
https://doaj.org/article/443a48f1b15144c592da76c19bd18475
Autor:
Anne Gigout, Donata Harazin, Louise M. Topping, Didier Merciris, Sven Lindemann, Christian Brenneis, Ahuva Nissim
Publikováno v:
Arthritis Research & Therapy, Vol 23, Iss 1, Pp 1-11 (2021)
Abstract Background Osteoarthritis (OA) is a disease of the whole joint, with articular cartilage breakdown as a major characteristic. Inflammatory mediators, proteases, and oxidants produced by chondrocytes are known to be responsible for driving ca
Externí odkaz:
https://doaj.org/article/e5482f8d14654940b82769ea2ce6dc76
Autor:
Solveig Skovlund Groen, Dovile Sinkeviciute, Anne-Christine Bay-Jensen, Christian S. Thudium, Morten A. Karsdal, Simon Francis Thomsen, Sven Lindemann, Daniela Werkmann, Joseph Blair, Line Mærsk Staunstrup, Patrik Önnerfjord, Lars Arendt-Nielsen, Signe Holm Nielsen
Publikováno v:
Osteoarthritis and Cartilage Open, Vol 3, Iss 4, Pp 100207- (2021)
Objectives: There is an unmet medical need for biomarkers in OA which can be applied in clinical drug development trials. The present study describes the development of a specific and robust assay measuring type II collagen degradation (T2CM) and dis
Externí odkaz:
https://doaj.org/article/dbead7b88abd48ba819c5601d42f0785
Autor:
Suzanne Ackloo, Albert A. Antolin, Jose Manuel Bartolome, Hartmut Beck, Alex Bullock, Ulrich A. K. Betz, Jark Böttcher, Peter J. Brown, Menorca Chaturvedi, Alisa Crisp, Danette Daniels, Jan Dreher, Kristina Edfeldt, Aled M. Edwards, Ursula Egner, Jon Elkins, Christian Fischer, Tine Glendorf, Steven Goldberg, Ingo V. Hartung, Alexander Hillisch, Evert Homan, Stefan Knapp, Markus Köster, Oliver Krämer, Josep Llaveria, Uta Lessel, Sven Lindemann, Lars Linderoth, Hisanori Matsui, Maurice Michel, Florian Montel, Anke Mueller-Fahrnow, Susanne Müller, Dafydd R. Owen, Kumar Singh Saikatendu, Vijayaratnam Santhakumar, Wendy Sanderson, Cora Scholten, Matthieu Schapira, Sujata Sharma, Brock Shireman, Michael Sundström, Matthew H. Todd, Claudia Tredup, Jennifer Venable, Timothy M. Willson, Cheryl H. Arrowsmith
Publikováno v:
RSC Medicinal Chemistry.
Target 2035, an international federation of biomedical scientists from the public and private sectors, is leveraging ‘open’ principles to develop a pharmacological tool for every human protein.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3307d439e596fca276308b7255fe64f6
https://doi.org/10.1039/d2md00441k
https://doi.org/10.1039/d2md00441k
Publikováno v:
Journal of Cellular and Molecular Medicine
The growth and differentiation factor 5 (GDF‐5) is known to play a key role in cartilage morphogenesis and homeostasis, and a single‐nucleotide polymorphism in its promoter sequence was found to be associated with osteoarthritis (OA). In addition
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1251d265dcf1b482ecf64606b1c509d
http://europepmc.org/articles/PMC7339174
http://europepmc.org/articles/PMC7339174
Publikováno v:
BioResearch Open Access
For cartilage repair in vivo or evaluation of new therapeutic approaches in vitro, the generation of functional cartilage tissue is of crucial importance and can only be achieved if the phenotype of the chondrocytes is preserved. Three-dimensional (3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::857d1f435ac52225b28e0a87cc980f0f
http://europepmc.org/articles/PMC7133430
http://europepmc.org/articles/PMC7133430
Autor:
Christian Brenneis, Donata Harazin, Didier Merciris, Anne Gigout, Sven Lindemann, Ahuva Nissim, Louise M. Topping
Publikováno v:
Arthritis Research & Therapy
Arthritis Research & Therapy, Vol 23, Iss 1, Pp 1-11 (2021)
Arthritis Research & Therapy, Vol 23, Iss 1, Pp 1-11 (2021)
Background Osteoarthritis (OA) is a disease of the whole joint, with articular cartilage breakdown as a major characteristic. Inflammatory mediators, proteases, and oxidants produced by chondrocytes are known to be responsible for driving cartilage d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf13e4bdcf95b9146c2b704b89f50e7a
http://europepmc.org/articles/PMC8045329
http://europepmc.org/articles/PMC8045329
Autor:
Benedikte Serruys, Anne Sofie Siebuhr, Christoph Ladel, Christian S. Thudium, M. Michaelis, A.-C. Bay-Jensen, Morten A. Karsdal, Daniela Werkmann, Sven Lindemann
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 5992, p 5992 (2020)
International Journal of Molecular Sciences
Volume 21
Issue 17
International Journal of Molecular Sciences
Volume 21
Issue 17
Osteoarthritis (OA) is associated with cartilage breakdown, brought about by ADAMTS-5 mediated aggrecan degradation followed by MMP-derived aggrecan and type II collagen degradation. We investigated a novel anti-ADAMTS-5 inhibiting Nanobody®
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b9d543454f6476fb2dd6d5a0b8702e9
https://www.mdpi.com/1422-0067/21/17/5992
https://www.mdpi.com/1422-0067/21/17/5992
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 2, p 531 (2020)
International Journal of Molecular Sciences
Volume 21
Issue 2
International Journal of Molecular Sciences
Volume 21
Issue 2
The environment surrounding chondrocytes changes drastically in osteoarthritis (OA). For instance, the osmolarity in cartilage (ranging from 350 to 460 mOsm in healthy tissue) decreases during the progression of OA, reaching 270 mOsm. The objective o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71b3041868ad63d969eba1f8f9bd4bd9
https://www.mdpi.com/1422-0067/21/2/531
https://www.mdpi.com/1422-0067/21/2/531
Autor:
Kerstin Kleinschmidt-Doerr, Anne Gigout, T. Mang, Andreas Schoenemann, Frank Ploeger, Sven Lindemann
Publikováno v:
Journal of Cell Science.
BMP2 stimulates bone formation and signals preferably through BMP receptor (BMPR) 1A, whereas GDF5 is a cartilage inducer and signals preferably through BMPR1B. Consequently, BMPR1A and BMPR1B are believed to be involved in bone and cartilage formati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bace8fc07c1890f0ad6606e4819c7fd4
https://doi.org/10.1242/jcs.246934
https://doi.org/10.1242/jcs.246934