Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Sven Kratochvil"'
Autor:
Melissa M. Lemke, Robert M. Theisen, Emily R. Bozich, Milla R. McLean, Christina Y. Lee, Ester Lopez, Supachai Rerks-Ngarm, Punnee Pitisuttithum, Sorachai Nitayaphan, Sven Kratochvil, Bruce D. Wines, P. Mark Hogarth, Stephen J. Kent, Amy W. Chung, Kelly B. Arnold
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Fc-mediated immune functions have been correlated with protection in the RV144 HIV vaccine trial and are important for immunity to a range of pathogens. IgG antibodies (Abs) that form complexes with Fc receptors (FcRs) on innate immune cells can acti
Externí odkaz:
https://doaj.org/article/35b3306aabcb40c09ff91806b53e7bb8
Autor:
Melissa M. Lemke, Milla R. McLean, Christina Y. Lee, Ester Lopez, Emily R. Bozich, Supachai Rerks-Ngarm, Punnee Pitisuttithum, Sorachai Nitayaphan, Sven Kratochvil, Bruce D. Wines, P. Mark Hogarth, Stephen J. Kent, Amy W. Chung, Kelly B. Arnold
Publikováno v:
Cell Reports Medicine, Vol 2, Iss 9, Pp 100386- (2021)
Summary: Immunoglobulin G (IgG) antibodies that activate Fc-mediated immune functions have been correlated with vaccine efficacy, but it is difficult to unravel the relative roles of multiple IgG and Fc receptor (FcR) features that have the capacity
Externí odkaz:
https://doaj.org/article/7ab01d1112034192a941db86e300e132
Autor:
Sven Kratochvil, Paul F. McKay, Amy W. Chung, Stephen J. Kent, Jill Gilmour, Robin J. Shattock
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Externí odkaz:
https://doaj.org/article/edf952f6b7ef48b698627399c5eb5110
Autor:
Jenna Anderson, Thorunn A. Olafsdottir, Sven Kratochvil, Paul F. McKay, Malin Östensson, Josefine Persson, Robin J. Shattock, Ali M. Harandi
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Systems biology approaches have recently provided new insights into the mechanisms of action of human vaccines and adjuvants. Here, we investigated early transcriptional signatures induced in whole blood of healthy subjects following vaccination with
Externí odkaz:
https://doaj.org/article/3e81b23e6dbe4c9a9d129174b4901d30
Autor:
Luke Muir, Paul F. McKay, Velislava N. Petrova, Oleksiy V. Klymenko, Sven Kratochvil, Christopher L. Pinder, Paul Kellam, Robin J. Shattock
Publikováno v:
Wellcome Open Research, Vol 2 (2018)
Background: Human memory B cells play a vital role in the long-term protection of the host from pathogenic re-challenge. In recent years the importance of a number of different memory B cell subsets that can be formed in response to vaccination or in
Externí odkaz:
https://doaj.org/article/b5a3c3da8db74ff9b512cf6c41b86ee0
Autor:
Sven Kratochvil, Paul F. McKay, Amy W. Chung, Stephen J. Kent, Jill Gilmour, Robin J. Shattock
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
Antibody subclasses exhibit extensive polymorphisms (allotypes) that could potentially impact the quality of HIV-vaccine induced B cell responses. Allotypes of immunoglobulin (Ig) G1, the most abundant serum antibody, have been shown to display alter
Externí odkaz:
https://doaj.org/article/54a797ad4dd9402ebeffd7bf565c8f2b
Autor:
Sven Kratochvil, Paul F. McKay, Jakub T. Kopycinski, Cynthia Bishop, Peter John Hayes, Luke Muir, Christopher L. Pinder, Deniz Cizmeci, Deborah King, Yoann Aldon, Bruce D. Wines, P. Mark Hogarth, Amy W. Chung, Stephen J. Kent, Kathrin Held, Christof Geldmacher, Len Dally, Nelson S. Santos, Tom Cole, Jill Gilmour, Sarah Fidler, Robin J. Shattock
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
A key aspect to finding an efficacious human immunodeficiency virus (HIV) vaccine is the optimization of vaccine schedules that can mediate the efficient maturation of protective immune responses. In the present study, we investigated the effect of a
Externí odkaz:
https://doaj.org/article/4c3b30ccf3f844fdb4a1bdab3e84d4fd
Autor:
Sai Luo, Changbin Jing, Adam Yongxin Ye, Sven Kratochvil, Christopher A. Cottrell, Ja-Hyun Koo, Aimee Chapdelaine Williams, Lucas Vieira Francisco, Himanshu Batra, Edward Lamperti, Oleksandr Kalyuzhniy, Yuxiang Zhang, Alessandro Barbieri, John P. Manis, Barton F. Haynes, William R. Schief, Facundo D. Batista, Ming Tian, Frederick W. Alt
Antibody heavy chain (HC) and light chain (LC) variable region exons are assembled by V(D)J recombination. V(D)J junctional regions encode complementarity-determining-region 3 (CDR3), an antigen-contact region immensely diversified through non-templa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a77f1f868d87a642a14bafeff3acf828
https://doi.org/10.1101/2022.10.12.511911
https://doi.org/10.1101/2022.10.12.511911
Autor:
Mateo Reveiz, Prabhanshu Tripathi, Lais Da Silva Pereira, Patience Kiyuka, Tracy Liu, Baoshan Zhang, Yongping Yang, Brian G. Bonilla, Marlon Dillon, Myungjin Lee, Chen-Hsiang Shen, Arne Schön, Sven Kratochvil, Facundo D. Batista, Azza H. Idris, Robert A. Seder, Peter D. Kwong, Reda Rawi
SUMMARYAntibody CIS43 binds Plasmodium falciparum circumsporozoite protein (PfCSP) and protects against malaria, as recently demonstrated clinically. To improve the efficacy of CIS43, we developed an in silico pipeline to optimize the interaction ene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::35c85dbac3ddfcc6042ff7373d650af4
https://doi.org/10.1101/2022.04.08.487687
https://doi.org/10.1101/2022.04.08.487687
Publikováno v:
Pharmacological reviews. 74(1)
We have experienced an enormous cohesive effort of the scientific community to understand how the immune system reacts to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and how to elicit protective immunity via vaccination. This effort