Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Sven Inerot"'
Publikováno v:
Journal of Orthopaedic Research. 19:149-154
The G1 regulatory pathway involving p16, pRb and cdk4 in the cell cycle has been investigated in human chondrosarcoma. The protein expression of p16, pRb and cdk4 was analyzed by Western blot in cultured cells from eight chondrosarcomas and in two ch
Publikováno v:
FEBS Letters. 438:85-90
The expression and localization of the helix-loop-helix transcription factors Id1 and Id3, as well as localization of the E12-protein, were studied in cells isolated from human articular cartilage and chondrosarcoma. Serum withdrawal down-regulated I
Autor:
Joel A. Block, Ashok A. Jagasia, Manuel O. Diaz, Tsutomu Nobori, Steven Gitelis, Anand P. Iyer, Sven Inerot
Publikováno v:
Cancer Letters. 105:77-90
Cytogenetic abnormalities of chromosome 9 (9p21) have been reported in a large number of tumors that include malignant melanomas, gliomas, lung cancers and leukemias. These aberrations on 9p have been previously shown to involve the loss of the inter
Publikováno v:
Journal of Biological Chemistry. 267:7245-7252
Newly synthesized 35S-labeled chondrocytic keratan sulfate chains were generated by chondrocytes of human chondrosarcoma cell line 105KC and were analyzed for heterogeneity of regional substitution, hydrodynamic size, and charge density. After isolat
Publikováno v:
Journal of Orthopaedic Research. 9:658-673
Degenerative hip joint disease was induced in dogs by extra-articular surgery that created a condition that mimics hip dysplasia. Decreased acetabular coverage of the femoral head gave altered mechanical load, with ensuing cartilage degeneration. For
Publikováno v:
The Journal of Bone & Joint Surgery. 73:647-658
Keratan sulphate is an integral component of the large aggregating proteoglycans of mature human articular cartilage. The keratan sulphate content of chondrocytic proteoglycans increases during maturation, and it is a useful marker of mature-type cho
Publikováno v:
Connective Tissue Research. 26:295-313
Articular cartilage chondrocytes maintain biosynthetic heterogeneity in cell culture, but undergo irreversible dedifferentiation of their proteoglycan phenotype, as defined by keratan sulfate content. A recently described cell line of malignant human
Autor:
Julia, Asp, Camilla, Brantsing, Karina, Lövstedt, Maria Serena, Benassi, Sven, Inerot, Gabriella, Gamberi, Piero, Picci, Anders, Lindahl
Publikováno v:
International journal of oncology. 27(6)
Both the tumour suppressor, p16, and the helix-loop-helix transcription factor, Id1, have been assigned roles in tumour growth in general and appear to be involved in chondrosarcoma. Id1 has further been found to repress the expression of p16. Theref
Autor:
Anders Lindahl, Julia Asp, Sven Inerot, Maria Serena Benassi, Luca Sangiorgi, Camilla Brantsing, Piero Picci
Publikováno v:
International journal of cancer. 93(5)
The locus encoding the tumor suppressor p16 has been found to code for a second, different protein. This protein, p14ARF, has been shown to protect p53 from degradation. Like p16, its gene is often altered in different cancers. In this study, the fir
Publikováno v:
Scandinavian Journal of Clinical and Laboratory Investigation. 45:421-427
An enzyme linked immunosorbent assay for the quantification of proteoglycans or proteoglycan fragments in biological fluids is presented. The assay has been used to determine concentrations of articular cartilage proteoglycans and/or fragments thereo