Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Sven Hennig"'
Autor:
Athanasios Blanas, Haiko Karsjens, Aafke de Ligt, Elisabeth J.M. Huijbers, Karlijn van Loon, Stepan S. Denisov, Canan Durukan, Diederik J.M. Engbersen, Jan Groen, Sven Hennig, Tilman M. Hackeng, Judy R. van Beijnum, Arjan W. Griffioen
Publikováno v:
iScience, Vol 25, Iss 8, Pp 104719- (2022)
Summary: Poor immunogenicity of critical epitopes can hamper vaccine efficacy. To boost immune recognition of non- or low-immunogenic antigens, we developed a vaccine platform based on the conjugation of a target protein to a chimeric designer peptid
Externí odkaz:
https://doaj.org/article/1255ada1fb7443d9a31a721694925fe9
Autor:
Sven Hennig, Holger M Strauss, Katja Vanselow, Ozkan Yildiz, Sabrina Schulze, Julia Arens, Achim Kramer, Eva Wolf
Publikováno v:
PLoS Biology, Vol 7, Iss 4, p e94 (2009)
PERIOD proteins are central components of the Drosophila and mammalian circadian clocks. The crystal structure of a Drosophila PERIOD (dPER) fragment comprising two PER-ARNT-SIM (PAS) domains (PAS-A and PAS-B) and two additional C-terminal alpha-heli
Externí odkaz:
https://doaj.org/article/ba3bcb2f0e6148f89f65062757d6f583
Autor:
Sebastian Kiehstaller, George H. Hutchins, Alessia Amore, Alan Gerber, Mohamed Ibrahim, Sven Hennig, Saskia Neubacher, Tom N. Grossmann
Publikováno v:
Kiehstaller, S, Hutchins, G H, Amore, A, Gerber, A, Ibrahim, M, Hennig, S, Neubacher, S & Grossmann, T N 2023, ' Bicyclic Engineered Sortase A Performs Transpeptidation under Denaturing Conditions ', Bioconjugate chemistry, vol. 34, no. 6, pp. 1114-1121 . https://doi.org/10.1021/acs.bioconjchem.3c00151
Bioconjugate chemistry. American Chemical Society
Bioconjugate chemistry. American Chemical Society
Enzymes are of central importance to many biotechnological and biomedical applications. However, for many potential applications, the required conditions impede enzyme folding and therefore function. The enzyme Sortase A is a transpeptidase that is w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::900073b38c8c7146288c8df4ea14297a
https://hdl.handle.net/1871.1/ce68c81f-f931-4ebd-93ed-e2d4861cf034
https://hdl.handle.net/1871.1/ce68c81f-f931-4ebd-93ed-e2d4861cf034
Publikováno v:
Angewandte Chemie. International Edition, 61(42):e202210592. Wiley
Horst, B, Verdoorn, D S, Hennig, S, van der Heijden, G & Ruijter, E 2022, ' Enantioselective Total Synthesis of (−)-Limaspermidine and (−)-Kopsinine by a Nitroaryl Transfer Cascade Strategy ', Angewandte Chemie. International Edition, vol. 61, no. 42, e202210592 . https://doi.org/10.1002/anie.202210592
Horst, B, Verdoorn, D S, Hennig, S, van der Heijden, G & Ruijter, E 2022, ' Enantioselective Total Synthesis of (−)-Limaspermidine and (−)-Kopsinine by a Nitroaryl Transfer Cascade Strategy ', Angewandte Chemie. International Edition, vol. 61, no. 42, e202210592 . https://doi.org/10.1002/anie.202210592
We report an intramolecular conjugate addition/Truce-Smiles/E1cb cascade of 2-nitrobenzenesulfonamide-functionalized cyclohexenones as a new entry to the core scaffold of monoterpene indole alkaloids. The method was applied to the asymmetric total sy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20acb3502c5b0e7522b484040c8fdf5f
https://research.vu.nl/en/publications/a7f15b7e-891b-40b2-866b-8f64d67e65bc
https://research.vu.nl/en/publications/a7f15b7e-891b-40b2-866b-8f64d67e65bc
Autor:
Alan Gerber, Sven Hennig, Rosa Bellavita, Isabel Everard, Thirza van Ramshorst, Elisabetta Chiarparin, Nina Louisa Efrém, Nicholas M Pearce, Paul R. J. Davey, Tom N. Grossmann, Paolo Grieco, Mathias Wendt, Mercedes Vazquez-Chantada
Publikováno v:
Angewandte Chemie (International Ed. in English)
Angewandte Chemie-International Edition, 60(25), 13937-13944. Wiley
Wendt, M, Bellavita, R, Gerber, A, Efrém, N L, van Ramshorst, T, Pearce, N M, Davey, P R J, Everard, I, Vazquez-Chantada, M, Chiarparin, E, Grieco, P, Hennig, S & Grossmann, T N 2021, ' Bicyclic β-Sheet Mimetics that Target the Transcriptional Coactivator β-Catenin and Inhibit Wnt Signaling ', Angewandte Chemie-International Edition, vol. 60, no. 25, pp. 13937-13944 . https://doi.org/10.1002/anie.202102082
Angewandte Chemie-International Edition, 60(25), 13937-13944. John Wiley and Sons Ltd
Angewandte Chemie-International Edition, 60(25), 13937-13944. Wiley
Wendt, M, Bellavita, R, Gerber, A, Efrém, N L, van Ramshorst, T, Pearce, N M, Davey, P R J, Everard, I, Vazquez-Chantada, M, Chiarparin, E, Grieco, P, Hennig, S & Grossmann, T N 2021, ' Bicyclic β-Sheet Mimetics that Target the Transcriptional Coactivator β-Catenin and Inhibit Wnt Signaling ', Angewandte Chemie-International Edition, vol. 60, no. 25, pp. 13937-13944 . https://doi.org/10.1002/anie.202102082
Angewandte Chemie-International Edition, 60(25), 13937-13944. John Wiley and Sons Ltd
Protein complexes are defined by the three‐dimensional structure of participating binding partners. Knowledge about these structures can facilitate the design of peptidomimetics which have been applied for example, as inhibitors of protein–protei
Autor:
Hans Daniel Preschel, Ruben T. Otte, Ying Zhuo, Rebecca E. Ruscoe, Ashleigh J. Burke, Rachel Cowan, Brendan Horst, Sven Hennig, Elwin Janssen, Anthony Green, Nicholas J. Turner, Eelco Ruijter
We report a new synthesis of the Covid-19 drug nirmatrelvir featuring a highly enantioselective biocatalytic desymmetrization and a diastereoselective multicomponent reaction as the key steps. Our route avoids the use of transition metals and peptide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7291b26a84f84106d988e26925684ff3
https://doi.org/10.26434/chemrxiv-2022-8r8h7
https://doi.org/10.26434/chemrxiv-2022-8r8h7
Autor:
Adrian Glas, Tom N. Grossmann, Fredrik L. Holmelin, Kerstin Wallraven, Sven Hennig, Andrey I. Frolov
Publikováno v:
Chemical Science
Wallraven, K, Holmelin, F L, Glas, A, Hennig, S, Frolov, A I & Grossmann, T N 2020, ' Adapting free energy perturbation simulations for large macrocyclic ligands : how to dissect contributions from direct binding and free ligand flexibility ', Chemical Science, vol. 11, no. 8, pp. 2269-2276 . https://doi.org/10.1039/c9sc04705k
Chemical Science, 11(8), 2269-2276. Royal Society of Chemistry
Wallraven, K, Holmelin, F L, Glas, A, Hennig, S, Frolov, A I & Grossmann, T N 2020, ' Adapting free energy perturbation simulations for large macrocyclic ligands : how to dissect contributions from direct binding and free ligand flexibility ', Chemical Science, vol. 11, no. 8, pp. 2269-2276 . https://doi.org/10.1039/c9sc04705k
Chemical Science, 11(8), 2269-2276. Royal Society of Chemistry
A combination of free energy perturbations and molecular dynamics simulations were applied to investigate large macrocyclic ligands and their receptor binding.
Large and flexible ligands gain increasing interest in the development of bioactive a
Large and flexible ligands gain increasing interest in the development of bioactive a
Autor:
Karin S. Altmann, Ina Lunk, Felix-Alexander Litty, Jürke Kotthaus, Carmen Carrillo García, Ingrid R. Vetter, Dennis Schade, Bernd Clement, Gudrun Ott, Antje Havemeyer, Sven Hennig
Publikováno v:
Lunk, I, Litty, F-A, Hennig, S, Vetter, I R, Kotthaus, J, Altmann, K S, Ott, G, Havemeyer, A, Carillo García, C, Clement, B & Schade, D 2020, ' Discovery of N-(4-Aminobutyl)-N '-(2-methoxyethyl)guanidine as the First Selective, Nonamino Acid, Catalytic Site Inhibitor of Human Dimethylarginine Dimethylaminohydrolase-1 ( h DDAH-1) ', Journal of Medicinal Chemistry, vol. 63, no. 1, pp. 425-432 . https://doi.org/10.1021/acs.jmedchem.9b01230
Journal of Medicinal Chemistry, 63(1), 425-432. American Chemical Society
Journal of Medicinal Chemistry, 63(1), 425-432. American Chemical Society
N-(4-Aminobutyl)-N′-(2-methoxyethyl)guanidine (8a) is a potent inhibitor targeting the hDDAH-1 active site (Ki = 18 μM) and derived from a series of guanidine- and amidine-based inhibitors. Its nonamino acid nature leads to high selectivities towa
Autor:
Mathias Wendt, Sven Hennig, Arne Kuepper, Nicole Pospiech, Diego Brancaccio, Sadasivam Jeganathan, Tom N. Grossmann, Ettore Novellino, Alfonso Carotenuto, Sebastian Kiehstaller
Publikováno v:
Angewandte Chemie (International Ed. in English)
Jeganathan, S, Wendt, M, Kiehstaller, S, Brancaccio, D, Kuepper, A, Pospiech, N, Carotenuto, A, Novellino, E, Hennig, S & Grossmann, T N 2019, ' Constrained Peptides with Fine-Tuned Flexibility Inhibit NF-Y Transcription Factor Assembly ', Angewandte Chemie. International Edition, vol. 58, no. 48, pp. 17351-17358 . https://doi.org/10.1002/anie.201907901
Angewandte Chemie
Jeganathan, S, Wendt, M, Kiehstaller, S, Brancaccio, D, Kuepper, A, Pospiech, N, Carotenuto, A, Novellino, E, Hennig, S & Grossmann, T N 2019, ' Constrained Peptides with Fine-Tuned Flexibility Inhibit NF-Y Transcription Factor Assembly ', Angewandte Chemie. International Edition, vol. 58, no. 48, pp. 17351-17358 . https://doi.org/10.1002/anie.201907901
Angewandte Chemie
Protein complex formation depends on the interplay between preorganization and flexibility of the binding epitopes involved. The design of epitope mimetics typically focuses on stabilizing a particular bioactive conformation, often without considerin
Autor:
André Richters, Sven Hennig
Publikováno v:
Drug discovery today. Technologies. 40