Zobrazeno 1 - 10
of 73
pro vyhledávání: '"Sven Heinz"'
Autor:
Paola Cattaneo, Michael G. B. Hayes, Nina Baumgarten, Dennis Hecker, Sofia Peruzzo, Galip S. Aslan, Paolo Kunderfranco, Veronica Larcher, Lunfeng Zhang, Riccardo Contu, Gregory Fonseca, Simone Spinozzi, Ju Chen, Gianluigi Condorelli, Stefanie Dimmeler, Marcel H. Schulz, Sven Heinz, Nuno Guimarães-Camboa, Sylvia M. Evans
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
How and whether histone modifications regulate distinct gene networks remains insufficiently understood. Here Cattaneo et al show that DOT1L catalyzed H3K79me2 regulates fetal chamber-specific gene expression and neonatal cardiomyocyte cell cycle wit
Externí odkaz:
https://doaj.org/article/af78efbb43a14df4a0071f5cb6653928
Publikováno v:
BMC Bioinformatics, Vol 21, Iss 1, Pp 1-22 (2020)
Abstract Background Mounting evidence suggests several diseases and biological processes target transcription termination to misregulate gene expression. Disruption of transcription termination leads to readthrough transcription past the 3′ end of
Externí odkaz:
https://doaj.org/article/c41be1592b4245c69859e99b40e02622
Autor:
Lorane Texari, Nathanael J. Spann, Ty D. Troutman, Mashito Sakai, Jason S. Seidman, Sven Heinz
Publikováno v:
STAR Protocols, Vol 2, Iss 1, Pp 100358- (2021)
Summary: Integrative analysis of next-generation sequencing data can help understand disease mechanisms. Specifically, ChIP-seq can illuminate where transcription regulators bind to regulate transcription. A major obstacle to performing this assay on
Externí odkaz:
https://doaj.org/article/4c519530be254408b8c8ba5990502ad4
Autor:
Ty D. Troutman, Hunter Bennett, Mashito Sakai, Jason S. Seidman, Sven Heinz, Christopher K. Glass
Publikováno v:
STAR Protocols, Vol 2, Iss 1, Pp 100363- (2021)
Summary: Significant advancements in understanding disease mechanisms can occur through combined analysis of next-generation sequencing datasets generated using purified cell populations. Here, we detail our optimized protocol for purification of mou
Externí odkaz:
https://doaj.org/article/2077200b90804f65be9a29826ae8a921
Autor:
Martin Wegner, Valentina Diehl, Verena Bittl, Rahel de Bruyn, Svenja Wiechmann, Yves Matthess, Marie Hebel, Michael GB Hayes, Simone Schaubeck, Christopher Benner, Sven Heinz, Anja Bremm, Ivan Dikic, Andreas Ernst, Manuel Kaulich
Publikováno v:
eLife, Vol 8 (2019)
Current technologies used to generate CRISPR/Cas gene perturbation reagents are labor intense and require multiple ligation and cloning steps. Furthermore, increasing gRNA sequence diversity negatively affects gRNA distribution, leading to libraries
Externí odkaz:
https://doaj.org/article/393c8588725544a5ab186bfe7246d237
Publikováno v:
Nanomaterials, Vol 10, Iss 6, p 1239 (2020)
The implementation of thermal barriers in thermoelectric materials improves their power conversion rates effectively. For this purpose, material boundaries are utilized and manipulated to affect phonon transmissivity. Specifically, interface intermix
Externí odkaz:
https://doaj.org/article/db640274872f4e6abe885442afdc1c7e
Autor:
Laure Escoubet-Lozach, Christopher Benner, Minna U Kaikkonen, Jean Lozach, Sven Heinz, Nathan J Spann, Andrea Crotti, Josh Stender, Serena Ghisletti, Donna Reichart, Christine S Cheng, Rosa Luna, Colleen Ludka, Roman Sasik, Ivan Garcia-Bassets, Alexander Hoffmann, Shankar Subramaniam, Gary Hardiman, Michael G Rosenfeld, Christopher K Glass
Publikováno v:
PLoS Genetics, Vol 7, Iss 12, p e1002401 (2011)
Precise control of the innate immune response is required for resistance to microbial infections and maintenance of normal tissue homeostasis. Because this response involves coordinate regulation of hundreds of genes, it provides a powerful biologica
Externí odkaz:
https://doaj.org/article/f69a8d7af71742de8be55e14a6e909d9
Publikováno v:
Cancer Research. 83:P3-11
Background: The Breast Cancer Index (BCI) is a gene expression-based signature comprising two functional biomarker panels. The Molecular Grade Index (MGI) is composed of five genes that measure tumor proliferation. BCI (H/I) is a ratio of the HOXB13
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9c55d07e59a3169647099378bd6924f0
https://doi.org/10.1158/1538-7445.sabcs22-p3-11-10
https://doi.org/10.1158/1538-7445.sabcs22-p3-11-10
Publikováno v:
NAR genomics and bioinformatics, vol 4, iss 4
Score-based motif enrichment analysis (MEA) is typically applied to regulatory DNA to infer transcription factors (TFs) that may modulate transcription and chromatin state in different conditions. Most MEA methods determine motif enrichment independe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4aa2408fa51d04cc25c39610d2057d36
https://escholarship.org/uc/item/5bh3w3bx
https://escholarship.org/uc/item/5bh3w3bx
Autor:
Paola Cattaneo, Michael G. B. Hayes, Nina Baumgarten, Dennis Hecker, Sofia Peruzzo, Paolo Kunderfranco, Veronica Larcher, Lunfeng Zhang, Riccardo Contu, Gregory Fonseca, Simone Spinozzi, Ju Chen, Gianluigi Condorelli, Marcel H Schulz, Sven Heinz, Nuno Guimarães-Camboa, Sylvia M. Evans
Mechanisms by which specific histone modifications regulate distinct gene regulatory networks remain little understood. We investigated how H3K79me2, a modification catalyzed by DOT1L and previously considered a general transcriptional activation mar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7814856d49dce2c16706950430d256fe
https://doi.org/10.1101/2022.10.18.512679
https://doi.org/10.1101/2022.10.18.512679