Výsledky vyhledávání - "Sven H. Hausner"

Akademický článek

A Comparison of Evans Blue and 4-(p-Iodophenyl)butyryl Albumin Binding Moieties on an Integrin αvβ6 Binding Peptide

Autor: Ryan A. Davis, Sven H. Hausner, Rebecca Harris, Julie L. Sutcliffe

Publikováno v: Pharmaceutics, Vol 14, Iss 4, p 745 (2022)

Serum albumin binding moieties (ABMs) such as the Evans blue (EB) dye fragment and the 4-(p-iodophenyl)butyryl (IP) have been used to improve the pharmacokinetic profile of many radiopharmaceuticals. The goal of this work was to directly compare thes

Externí odkaz: https://doaj.org/article/ab89510f9ce1449c961c8aa27dc4f78f

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Akademický článek

Evaluation of [Cu]Cu-DOTA and [Cu]Cu-CB-TE2A Chelates for Targeted Positron Emission Tomography with an αβ-Specific Peptide

Autor: Sven H. Hausner, David L. Kukis, M. Karen J. Gagnon, Catherine E. Stanecki, Riccardo Ferdani, John F. Marshall, Carolyn J. Anderson, Julie L. Sutcliffe

Publikováno v: Molecular Imaging, Vol 8 (2009)

Significant upregulation of the integrin α v β 6 has been described as a prognostic indicator in several cancers, making it an attractive target for tumor imaging. This study compares variants of a PEGylated α v β 6 -targeting peptide, bearing ei

Externí odkaz: https://doaj.org/article/6f6b4575e93d469e99ad93a943a6c830

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Table S2 from Preclinical Development and First-in-Human Imaging of the Integrin αvβ6 with [18F]αvβ6-Binding Peptide in Metastatic Carcinoma

Autor: Julie L. Sutcliffe, Edward J. Kim, Cameron C. Foster, Ryan A. Davis, Megan E. Daly, Helen K. Chew, Lina Y. Cheuy, Richard J. Bold, Sven H. Hausner

Shows the biodistribution data for [18F]αvβ6-BP in mice bearing paired αvβ6-expressing DX3puroβ6 and non-αvβ6-expressing DX3puro xenograft tumors at 1, 2 and 4 h p.i. and at 1 h p.i. after pre-administration of blocking peptide. Tissue uptake

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78af266f4811fbf64af07f8e9bde8240
https://doi.org/10.1158/1078-0432.22467603.v1

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Data from Preclinical Development and First-in-Human Imaging of the Integrin αvβ6 with [18F]αvβ6-Binding Peptide in Metastatic Carcinoma

Autor: Julie L. Sutcliffe, Edward J. Kim, Cameron C. Foster, Ryan A. Davis, Megan E. Daly, Helen K. Chew, Lina Y. Cheuy, Richard J. Bold, Sven H. Hausner

Purpose:The study was undertaken to develop and evaluate the potential of an integrin αvβ6-binding peptide (αvβ6-BP) for noninvasive imaging of a diverse range of malignancies with PET.Experimental Design:The peptide αvβ6-BP was prepared on sol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::405e7502a084ce6f15ffd02e8f1fe0fa
https://doi.org/10.1158/1078-0432.c.6526695.v1

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Figure S2 from Preclinical Development and First-in-Human Imaging of the Integrin αvβ6 with [18F]αvβ6-Binding Peptide in Metastatic Carcinoma

Autor: Julie L. Sutcliffe, Edward J. Kim, Cameron C. Foster, Ryan A. Davis, Megan E. Daly, Helen K. Chew, Lina Y. Cheuy, Richard J. Bold, Sven H. Hausner

Shows the in vivo stability of [18F]αvβ6-BP in human blood. Representative radio-HPLC of blood sample taken 30 min post injection. Top: Sample only; bottom: sample spiked with [18F]αvβ6-BP. X-axis: retention time [min]; Y-axis: detector response

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62c46e86ac37f7576a9f3f73d85ecbe1
https://doi.org/10.1158/1078-0432.22467612.v1

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