Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Sven H, Hausner"'
Publikováno v:
Pharmaceutics, Vol 14, Iss 4, p 745 (2022)
Serum albumin binding moieties (ABMs) such as the Evans blue (EB) dye fragment and the 4-(p-iodophenyl)butyryl (IP) have been used to improve the pharmacokinetic profile of many radiopharmaceuticals. The goal of this work was to directly compare thes
Externí odkaz:
https://doaj.org/article/ab89510f9ce1449c961c8aa27dc4f78f
Autor:
Tanushree Ganguly, Nadine Bauer, Ryan A. Davis, Cameron C. Foster, Rebecca E. Harris, Sven H. Hausner, Emilie Roncali, Sarah Y. Tang, Julie L. Sutcliffe
Publikováno v:
Journal of Nuclear Medicine. 64:639-644
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::37eb7938b46272c2ea4e891899563fa6
https://doi.org/10.2967/jnumed.122.264749
https://doi.org/10.2967/jnumed.122.264749
Autor:
Julie L. Sutcliffe, Edward J. Kim, Cameron C. Foster, Ryan A. Davis, Megan E. Daly, Helen K. Chew, Lina Y. Cheuy, Richard J. Bold, Sven H. Hausner
Shows the biodistribution data for [18F]αvβ6-BP in mice bearing paired αvβ6-expressing DX3puroβ6 and non-αvβ6-expressing DX3puro xenograft tumors at 1, 2 and 4 h p.i. and at 1 h p.i. after pre-administration of blocking peptide. Tissue uptake
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78af266f4811fbf64af07f8e9bde8240
https://doi.org/10.1158/1078-0432.22467603.v1
https://doi.org/10.1158/1078-0432.22467603.v1
Autor:
Julie L. Sutcliffe, Edward J. Kim, Cameron C. Foster, Ryan A. Davis, Megan E. Daly, Helen K. Chew, Lina Y. Cheuy, Richard J. Bold, Sven H. Hausner
Purpose:The study was undertaken to develop and evaluate the potential of an integrin αvβ6-binding peptide (αvβ6-BP) for noninvasive imaging of a diverse range of malignancies with PET.Experimental Design:The peptide αvβ6-BP was prepared on sol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::405e7502a084ce6f15ffd02e8f1fe0fa
https://doi.org/10.1158/1078-0432.c.6526695.v1
https://doi.org/10.1158/1078-0432.c.6526695.v1
Autor:
Julie L. Sutcliffe, Edward J. Kim, Cameron C. Foster, Ryan A. Davis, Megan E. Daly, Helen K. Chew, Lina Y. Cheuy, Richard J. Bold, Sven H. Hausner
Shows the in vivo stability of [18F]αvβ6-BP in human blood. Representative radio-HPLC of blood sample taken 30 min post injection. Top: Sample only; bottom: sample spiked with [18F]αvβ6-BP. X-axis: retention time [min]; Y-axis: detector response
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62c46e86ac37f7576a9f3f73d85ecbe1
https://doi.org/10.1158/1078-0432.22467612.v1
https://doi.org/10.1158/1078-0432.22467612.v1
Autor:
Julie L. Sutcliffe, Edward J. Kim, Cameron C. Foster, Ryan A. Davis, Megan E. Daly, Helen K. Chew, Lina Y. Cheuy, Richard J. Bold, Sven H. Hausner
Describes additional methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1df5ae43674db2d9248b8862f34eef09
https://doi.org/10.1158/1078-0432.22467609.v1
https://doi.org/10.1158/1078-0432.22467609.v1
Expression of the epithelial-specific integrin αvβ6 is low or undetectable in most adult tissues but may be increased during wound healing and inflammation and is up-regulated dramatically by many different carcinomas, making αvβ6 a promising tar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69c0cbdfe594cd65b7cddac09d2d443a
https://doi.org/10.1158/0008-5472.c.6495953
https://doi.org/10.1158/0008-5472.c.6495953
Supplementary Figure 1 from Use of a Peptide Derived from Foot-and-Mouth Disease Virus for the Noninvasive Imaging of Human Cancer: Generation and Evaluation of 4-[18F]Fluorobenzoyl A20FMDV2 for In vivo Imaging of Integrin αvβ6 Expression with Posi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::777d88abc9aa78854b4f003a5b32c232
https://doi.org/10.1158/0008-5472.22368422.v1
https://doi.org/10.1158/0008-5472.22368422.v1
Autor:
Julie L. Sutcliffe, Cathy E. Stanecki, John F. Marshall, Jan Marik, M. Karen Gagnon, Richard J. Bold, Craig K. Abbey, Sven H. Hausner
Supplementary Methods, Table, Figures 1-4 from Targeted In vivo Imaging of Integrin αvβ6 with an Improved Radiotracer and Its Relevance in a Pancreatic Tumor Model
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ae0cc75aeedd3ed7d3d654a24c34a5e
https://doi.org/10.1158/0008-5472.22378548
https://doi.org/10.1158/0008-5472.22378548
Autor:
Nadine Bauer, Sven H. Hausner, Ryan A. Davis, Tanushree Ganguly, Sarah Y. Tang, Julie L. Sutcliffe
Publikováno v:
Molecular Pharmaceutics. 18:4437-4447
The incorporation of non-covalent albumin binding moieties (ABMs) into radiotracers results in increased circulation time, leading to a higher uptake in the target tissues such as the tumor, and, in some cases, reduced kidney retention. We previously
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e4abaeef7e7f3d9e6622d907fe315dac
https://doi.org/10.1021/acs.molpharmaceut.1c00632
https://doi.org/10.1021/acs.molpharmaceut.1c00632