Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Sven De Bruycker"'
Autor:
Euy Sung Moon, Filipe Elvas, Gwendolyn Vliegen, Stef De Lombaerde, Christel Vangestel, Sven De Bruycker, An Bracke, Elisabeth Eppard, Lukas Greifenstein, Benedikt Klasen, Vasko Kramer, Steven Staelens, Ingrid De Meester, Pieter Van der Veken, Frank Rösch
Publikováno v:
EJNMMI Radiopharmacy and Chemistry, Vol 5, Iss 1, Pp 1-20 (2020)
Abstract Background Fibroblast activation protein (FAP) is a proline selective serine protease that is overexpressed in tumor stroma and in lesions of many other diseases that are characterized by tissue remodeling. In 2014, a most potent FAP-inhibit
Externí odkaz:
https://doaj.org/article/6eef6de76ec3424eabc82ef799f24e24
Autor:
Farnaz Sedigheh Takhsha, Christel Vangestel, Muhammet Tanc, Sven De Bruycker, Maya Berg, Isabel Pintelon, Sigrid Stroobants, Guido R. Y. De Meyer, Pieter Van Der Veken, Wim Martinet
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
Resistance against anti-cancer therapy is one of the major challenges during treatment of multiple cancers. Gemcitabine is a standard first-line chemotherapeutic drug, yet autophagy is highly activated in the hypoxic microenvironment of solid tumors
Externí odkaz:
https://doaj.org/article/55fbe685450a4b71836730ffe552e10b
Autor:
Sven De Bruycker, Christel Vangestel, Steven Staelens, Leonie wyffels, Jan Detrez, Marlies Verschuuren, Winnok H. De Vos, Patrick Pauwels, Tim Van den Wyngaert, Sigrid Stroobants
Publikováno v:
EJNMMI Research, Vol 9, Iss 1, Pp 1-10 (2019)
Abstract Background In a colorectal cancer xenograft model, we investigated the therapeutic effect of metformin on tumor hypoxia with [18F]flortanidazole ([18F]HX4) small-animal positron emission tomography (μPET). We also assessed the additive effe
Externí odkaz:
https://doaj.org/article/96e7e89be82f4b9083fbe6c24e466e63
Autor:
Yanina Dockx, Christel Vangestel, Tim Van den Wyngaert, Manon Huizing, Sven De Bruycker, Patrick Pauwels, Steven Staelens, Sigrid Stroobants
Publikováno v:
Molecular Imaging, Vol 2021 (2021)
We investigated the potential use of [18F]FDG PET as a response biomarker for PI3K pathway targeting therapies in two HER-2-overexpressing cancer models. Methods. CD-1 nude mice were inoculated with HER-2-overexpressing JIMT1 (trastuzumab-resistant)
Externí odkaz:
https://doaj.org/article/eb9d3dee84124c6e8c9f353af6a79a5e
Autor:
Yanina Dockx, Christel Vangestel, Sven De Bruycker, Tim Van den Wyngaert, Manon Huizing, Steven Staelens, Sigrid Stroobants
Publikováno v:
Cancer Biotherapy and Radiopharmaceuticals. 38:51-61
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e7833c0a5464a7dbac3f72a657790cf8
https://doi.org/10.1089/cbr.2022.0061
https://doi.org/10.1089/cbr.2022.0061
Autor:
Steven Staelens, Sven De Bruycker, Manon T. Huizing, Yanina Dockx, Christel Vangestel, Tim Van den Wyngaert, Sigrid Stroobants, Patrick Pauwels
Publikováno v:
Molecular Imaging, Vol 2021 (2021)
Molecular Imaging
Molecular Imaging
We investigated the potential use of [18F]FDG PET as a response biomarker for PI3K pathway targeting therapies in two HER-2-overexpressing cancer models. Methods. CD-1 nude mice were inoculated with HER-2-overexpressing JIMT1 (trastuzumab-resistant)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f251ee1a8fe206609886531f1d53a810
https://doaj.org/article/eb9d3dee84124c6e8c9f353af6a79a5e
https://doaj.org/article/eb9d3dee84124c6e8c9f353af6a79a5e
Autor:
Christel Vangestel, Tim Van den Wyngaert, Steven Staelens, Sigrid Stroobants, Sven De Bruycker
Publikováno v:
Contrast Media & Molecular Imaging
Contrast Media & Molecular Imaging, Vol 2018 (2018)
Contrast media and molecular imaging
Contrast Media & Molecular Imaging, Vol 2018 (2018)
Contrast media and molecular imaging
Tumor hypoxia is related with tumor aggressiveness, chemo- and radiotherapy resistance, and thus a poor clinical outcome. Therefore, over the past decades, every effort has been made to develop strategies to battle the negative prognostic influence o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d5eabc3806e260a6e2fc0fcf77ac1f6
https://doi.org/10.1155/2018/4608186
https://doi.org/10.1155/2018/4608186
Autor:
Tim Van den Wyngaert, Christel Vangestel, Sigrid Stroobants, Patrick Pauwels, Steven Staelens, Sven De Bruycker, Leonie Wyffels
Publikováno v:
Journal of Nuclear Medicine. 60:34-40
Metformin may improve tumor oxygenation and thus radiotherapy response, but imaging biomarkers for selection of suitable patients are still under investigation. First, we assessed the effect of acute metformin administration on non-small cell lung ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::27cdd2a78d3ba6285f0b3a8742b5b0ca
https://doi.org/10.2967/jnumed.118.212225
https://doi.org/10.2967/jnumed.118.212225
Autor:
Jolien Van den Bossche, An Wouters, Christophe Deben, Ines De Pauw, Sven De Bruycker, Julie Jacobs, Filip Lardon, Andreas Domen, Marc Peeters, Jan B. Vermorken, Pol Specenier, Patrick Pauwels
Publikováno v:
Cancers
CANCERS
Cancers; Volume 11; Issue 12; Pages: 1893
CANCERS
Cancers; Volume 11; Issue 12; Pages: 1893
Polo-like kinase 1 (Plk1), a master regulator of mitotic cell division, is highly expressed in non-small cell lung cancer (NSCLC) making it an interesting drug target. We examined the in vitro therapeutic effects of volasertib, a Plk1 inhibitor, in c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce13cb4be1554a2b3aadc6eff5a81bc1
https://pubmed.ncbi.nlm.nih.gov/31795121
https://pubmed.ncbi.nlm.nih.gov/31795121
Autor:
Steven Staelens, Winnok H. De Vos, Patrick Pauwels, Jan R. Detrez, Tim Van den Wyngaert, Christel Vangestel, Sven De Bruycker, Marlies Verschuuren, Leonie Wyffels, Sigrid Stroobants
Publikováno v:
EJNMMI research
EJNMMI Research, Vol 9, Iss 1, Pp 1-10 (2019)
EJNMMI Research, Vol 9, Iss 1, Pp 1-10 (2019)
Background In a colorectal cancer xenograft model, we investigated the therapeutic effect of metformin on tumor hypoxia with [F-18]flortanidazole ([F-18]HX4) small-animal positron emission tomography (mu PET). We also assessed the additive effect of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c6c7affc6550bfcd83fa5c6dad02b77
https://repository.uantwerpen.be/docman/irua/e479a7/161838.pdf
https://repository.uantwerpen.be/docman/irua/e479a7/161838.pdf