Zobrazeno 1 - 10 of 14 pro vyhledávání: '"Sven C. van Dijkman"'
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Akademický článek
Population Pharmacokinetic Modeling of Abacavir/Dolutegravir/Lamivudine to Support a Fixed-Dose Combination in Children with HIV-1
Autor: Hardik Chandasana, Sven C. van Dijkman, Rashmi Mehta, Mark Bush, Helena Rabie, Patricia Flynn, Tim R. Cressey, Edward P. Acosta, Kristina M. Brooks, for the IMPAACT 2019 Study Team
Publikováno v: Infectious Diseases and Therapy, Vol 13, Iss 8, Pp 1877-1891 (2024)
Abstract Introduction Once-daily fixed-dose combinations (FDC) containing abacavir (ABC), dolutegravir (DTG), and lamivudine (3TC) have been approved in the US for adults and children with HIV weighing ≥ 6 kg. This analysis assessed the ability of
Externí odkaz: https://doaj.org/article/e73069ec1f6d483aaaca734cc3350bf7
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2
Cardiac sodium channel inhibition by lamotrigine: In vitro characterization and clinical implications
Autor: Lindsey Ingleby‐Talecki, Sven C. van Dijkman, Sean P. Oosterholt, Oscar Della Pasqua, Christina Winter, Marianne Cunnington, Linda Rebar, Sergio Forero‐Schwanhaeuser, Vickas Patel, James A. Cooper, Anthony Bahinski, Khuram W. Chaudhary
Publikováno v: Clinical and Translational Science. 15:1978-1989
Lamotrigine, approved for use as an antiseizure medication as well as the treatment of bipolar disorder, inhibits sodium channels in the brain to reduce repetitive neuronal firing and pathological release of glutamate. The shared homology of sodium c
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3f18ff99d80882597d348c4c95576a5
https://doi.org/10.1111/cts.13311
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3
Futility of current urine salbutamol doping control
Autor: Jules A. A. C. Heuberger, Adam F. Cohen, Sven C. van Dijkman
Publikováno v: British Journal of Clinical Pharmacology. 84:1830-1838
Aims Salbutamol is used in the management of obstructive bronchospasm, including that of some elite athletes. It is claimed that high salbutamol (oral) doses may also have an anabolic effect. Therefore, inhalation of salbutamol is restricted by the W
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d9ef762bea9da92d99235d358407657f
https://doi.org/10.1111/bcp.13619
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4
Effect of Age-Related Factors on the Pharmacokinetics of Lamotrigine and Potential Implications for Maintenance Dose Optimisation in Future Clinical Trials
Autor: Nico C. B. de Jager, Meindert Danhof, Sven C. van Dijkman, Oscar Della Pasqua, Willem M. Rauwé
Publikováno v: Clinical Pharmacokinetics. 57:1039-1053
In this study, we evaluate the performance of allometric concepts to predict the implications of age and size on the pharmacokinetics of lamotrigine, and assess the dose rationale across different age groups from 0.2 to 91 years.An allometrically sca
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2f012b0ecee20bec6b756c573e85671
https://doi.org/10.1007/s40262-017-0614-5
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5
Pharmacokinetic interactions and dosing rationale for antiepileptic drugs in adults and children
Autor: Meindert Danhof, Sven C. van Dijkman, Oscar Della Pasqua, Willem M. Rauwé
Publikováno v: British Journal of Clinical Pharmacology. 84:97-111
Aims Population pharmacokinetic modelling has been widely used across many therapeutic areas to identify sources of variability, which are incorporated into models as covariate factors. Despite numerous publications on pharmacokinetic drug–drug int
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d4e217ce3568a4bd7e94922a71fe5a69
https://doi.org/10.1111/bcp.13400
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6
Population pharmacokinetics of oxcarbazepine and its metabolite 10-hydroxycarbazepine in healthy subjects
Autor: Veriano Alexandre Júnior, Oscar Della Pasqua, Natalícia de Jesus Antunes, Sven C. van Dijkman, Vera Lucia Lanchote, Eduardo Tozatto, J. G. Coen van Hasselt, Osvaldo Massaiti Takayanagui, Eduardo Barbosa Coelho, Lauro Wichert-Ana
Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Oxcarbazepine is indicated for the treatment of partial or generalised tonic-clonic seizures. Most of the absorbed oxcarbazepine is converted into its active metabolite, 10-hydroxycarbazepine (MHD), which can exist as R-(-)- and S-(+)-MHD enantiomers
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::283227249b275fa13ac1a2d1bee975a3
https://doi.org/10.1016/j.ejps.2017.05.034
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7
Individualized Dosing Algorithms and Therapeutic Monitoring for Antiepileptic Drugs
Autor: Sven C. van Dijkman, Sebastian G. Wicha, Oscar Della Pasqua, Meindert Danhof
Publikováno v: Clinical Pharmacology & Therapeutics. 103:663-673
Pharmacokinetic (PK) models exist for most antiepileptic drugs (AEDs). Yet their use in clinical practice to assess interindividual differences and derive individualized doses has been limited. Here we show how model-based dosing algorithms can be us
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af8ee6cb813d91d0c71d984acf78a17d
https://doi.org/10.1002/cpt.777
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9
Pharmacotherapy in pediatric epilepsy: from trial and error to rational drug and dose selection – a long way to go
Autor: Oscar Della Pasqua, Ricardo Alvarez-Jimenez, Sven C. van Dijkman, Meindert Danhof
Publikováno v: van Dijkman, S C, Alvarez-Jimenez, R, Danhof, M & Della Pasqua, O 2016, ' Pharmacotherapy in pediatric epilepsy : from trial and error to rational drug and dose selection – a long way to go ', Expert Opinion on Drug Metabolism and Toxicology, vol. 12, no. 10, pp. 1143-1156 . https://doi.org/10.1080/17425255.2016.1203900
Introduction: Whereas ongoing efforts in epilepsy research focus on the underlying disease processes, the lack of a physiologically based rationale for drug and dose selection contributes to inadequate treatment response in children. In fact, limited
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd20c42df406c53e9b793a4361bdc768
https://doi.org/10.1080/17425255.2016.1203900
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10
Dose rationale and pharmacokinetics of dexmedetomidine in mechanically ventilated new-borns: impact of design optimisation
Autor: Oscar Della Pasqua, Johan Vande Walle, Pieter De Cock, Karel Allegaert, W Decaluwe, Anne Smits, Sven C. van Dijkman, Peter De Paepe, Koenraad Smets
Publikováno v: EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
European Journal of Clinical Pharmacology, 75(10), 1393-1404. Springer-Verlag
PURPOSE: There is a need for alternative analgosedatives such as dexmedetomidine in neonates. Given the ethical and practical difficulties, protocol design for clinical trials in neonates should be carefully considered before implementation. Our obje
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6672ed6c17d0e6974e51c6b4eff85a7d
https://pubmed.ncbi.nlm.nih.gov/31312867
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