Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Sven Brenner"'
Autor:
Katharina Essig, Nina Kronbeck, Joao C. Guimaraes, Claudia Lohs, Andreas Schlundt, Anne Hoffmann, Gesine Behrens, Sven Brenner, Joanna Kowalska, Cristina Lopez-Rodriguez, Jacek Jemielity, Helmut Holtmann, Kristin Reiche, Jörg Hackermüller, Michael Sattler, Mihaela Zavolan, Vigo Heissmeyer
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
Roquin targets are known to contain two types of sequence-structure motifs, the constitutive and the alternative decay elements (CDE and ADE). Here, the authors describe a linear Roquin binding element (LBE) also involved in target recognition, and s
Externí odkaz:
https://doaj.org/article/314fcd580797451983c726cd599eaae1
Autor:
Nina Rehage, Elena Davydova, Christine Conrad, Gesine Behrens, Andreas Maiser, Jenny E. Stehklein, Sven Brenner, Juliane Klein, Aicha Jeridi, Anne Hoffmann, Eunhae Lee, Umberto Dianzani, Rob Willemsen, Regina Feederle, Kristin Reiche, Jörg Hackermüller, Heinrich Leonhardt, Sonia Sharma, Dierk Niessing, Vigo Heissmeyer
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
The RNA-binding proteins Roquin-1 and Roquin-2 are essential for immune cell function and postnatal survival in mice. Here, the authors identify NUFIP2 as a cofactor of Roquin; Roquin binds and stabilizes NUFIP2 in cells while NUFIP2 regulates Roquin
Externí odkaz:
https://doaj.org/article/07ebcb03963546dcad91d3831f14ddd0
Autor:
Robert Janowski, Gitta A. Heinz, Andreas Schlundt, Nina Wommelsdorf, Sven Brenner, Andreas R. Gruber, Michael Blank, Thorsten Buch, Raymund Buhmann, Mihaela Zavolan, Dierk Niessing, Vigo Heissmeyer, Michael Sattler
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
Roquin is an RNA-binding protein that prevents autoimmunity by limiting expression of receptors such as Ox40. Here, the authors identify an RNA structure that they describe as an alternative decay element, and they characterise its interaction with R
Externí odkaz:
https://doaj.org/article/be1a189912b647edb8ff00db7603f09a
Autor:
Gesine Behrens, Christine Conrad, Rob Willemsen, Sonia Sharma, Regina Feederle, Kristin Reiche, Eunhae Lee, Sven Brenner, Vigo Heissmeyer, Dierk Niessing, Andreas Maiser, Anne Hoffmann, Juliane Klein, Umberto Dianzani, Jenny E. Stehklein, Nina Rehage, Aicha Jeridi, Jörg Hackermüller, Elena S. Davydova, Heinrich Leonhardt
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
Nat. Commun. 9:299 (2018)
Nature Communications, 9:299. Nature Publishing Group
Nature Communications
Nat. Commun. 9:299 (2018)
Nature Communications, 9:299. Nature Publishing Group
Nature Communications
The ubiquitously expressed RNA-binding proteins Roquin-1 and Roquin-2 are essential for appropriate immune cell function and postnatal survival of mice. Roquin proteins repress target mRNAs by recognizing secondary structures in their 3′-UTRs and b
Autor:
Gesine Behrens, Andreas Schlundt, Joao C. Guimaraes, Jacek Jemielity, Mihaela Zavolan, Vigo Heissmeyer, Michael Sattler, Kristin Reiche, Helmut Holtmann, Sven Brenner, Jörg Hackermüller, Cristina López-Rodríguez, Anne Hoffmann, Claudia Lohs, Katharina Essig, Nina Kronbeck, Joanna Kowalska
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
Recercat. Dipósit de la Recerca de Catalunya
instname
Recercat. Dipósit de la Recerca de Catalunya
instname
The RNA-binding proteins Roquin-1 and Roquin-2 redundantly control gene expression and cell-fate decisions. Here, we show that Roquin not only interacts with stem–loop structures, but also with a linear sequence element present in about half of its
Autor:
Sven Brenner, Hans-Martin Jäck, Andreas Brandl, Jürgen Wittmann, Desmond Y H Yap, Sebastian R. Schulz, Michael R. Bösl, Patrick Daum, Wolfgang Schuh
Publikováno v:
European journal of immunology. 46(12)
microRNAs (miRNAs) are important posttranscriptional regulators during hematopoietic lineage commitment and lymphocyte development. Mature miRNAs are processed from primary miRNA transcripts in two steps by the microprocessor complex, consisting of D
Autor:
Vigo Heissmeyer, Sven Brenner, Nina Wommelsdorf, Andreas Gruber, Mihaela Zavolan, Michael Sattler, Gitta Anne Heinz, Dierk Niessing, Andreas Schlundt, Robert Janowski, Thorsten Buch, Michael Blank, Raymund Buhmann
Publikováno v:
Nature Communications
'Nature Communications ', vol: 7, pages: 11032-1-11032-13 (2016)
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
'Nature Communications ', vol: 7, pages: 11032-1-11032-13 (2016)
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
The RNA-binding protein Roquin is required to prevent autoimmunity. Roquin controls T-helper cell activation and differentiation by limiting the induced expression of costimulatory receptors such as tumor necrosis factor receptor superfamily 4 (Tnfrs
Autor:
Nina Rehage, Katharina U. Vogel, Claudia Lohs, Axel Kallies, Arie Geerlof, Desheng Hu, Helmut Holtmann, Elisabeth Kremmer, Mingui Fu, Jenny E. Stehklein, Katharina M. Jeltsch, Jürgen Ruland, Achim Weber, Sven Brenner, Stephanie L. Edelmann, Daniel Nagel, Marc Schmidt-Supprian, Daniel Krappmann, Maciej Lech, Nina A. Martin, Ingo Schmitz, Gitta Anne Heinz, Hans-Joachim Anders, Mathias Heikenwalder, Sebastian C. Warth, Renee Gloury, Jessica Zöller, Vigo Heissmeyer
Publikováno v:
Nature Immunology
Humoral autoimmunity paralleled by the accumulation of follicular helper T cells (T(FH) cells) is linked to mutation of the gene encoding the RNA-binding protein roquin-1. Here we found that T cells lacking roquin caused pathology in the lung and acc
Autor:
Harri Nurmi, Tine V. Karlsen, Natalia Rakova, Michael Boschmann, Jonathan Jantsch, Dominik N. Müller, Olav Tenstad, David G. Harrison, Agnes Schröder, Kari Alitalo, Helge Wiig, Maija Bry, Eero Mervaala, Jennifer Goss, Christoph W. Kopp, Anke Dahlmann, Dontscho Kerjaschki, Wolfgang Neuhofer, F. X. Beck, Friedrich C. Luft, Jens Titze, Sven Brenner, Hubertus Wagner
The skin interstitium sequesters excess Na+ and Cl- in salt-sensitive hypertension. Mononuclear phagocyte system (MPS) cells are recruited to the skin, sense the hypertonic electrolyte accumulation in skin, and activate the tonicity-responsive enhanc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0946198704bed0f19715eb09c9762c7e
https://europepmc.org/articles/PMC3696542/
https://europepmc.org/articles/PMC3696542/
Publikováno v:
Hypertension. 60
Background: We have shown previously that electrolyte homeostasis is characterized by local regulation of water-free Na + storage in the skin. Macrophages infiltrate the Na + overloaded skin interstitium and induce interstitial electrolyte clearance