Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Sven A. König-Merediz"'
Autor:
Alberto Marco, Manuel Schmidt, Matthias Schroff, Burghardt Wittig, Sven A. König-Merediz, Nicole Hagner
Publikováno v:
Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
Nucleic Acid Therapeutics
Universitat Autònoma de Barcelona
Nucleic Acid Therapeutics
Single-stranded oligodeoxynucleotides (ODN), containing nonmethylated cytosine-guanine motifs (CpG ODN), are recognized by the innate immune system as "danger signals." CpG ODN are efficacious immunomodulators but require phosphorothioate (PT) or oth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a78da9138cdd7f918eae25255cff619
https://ddd.uab.cat/record/185280
https://ddd.uab.cat/record/185280
Autor:
Jörg Reimann, Reinhold Schirmbeck, Claas Junghans, Petra Riedl, Florian Sack, Sven A. König-Merediz, Matthias Schroff, Burghardt Wittig, Marcin Kwissa
Publikováno v:
Journal of Molecular Medicine. 79:343-350
Nuclear localization signal (NLS) peptides conjugated to DNA increase transfection efficiency in vitro. We tested in mice whether conjugation of NLS peptides to DNA vaccines enhances their immunogenicity after intramuscular injection or gene gun medi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a69df096175b4553fe2666f2de981df1
https://doi.org/10.1007/s001090100227
https://doi.org/10.1007/s001090100227
Autor:
Frank, Schakowski, Marcus, Gorschlüter, Peter, Buttgereit, Angela, Märten, Marie V, Lilienfeld-Toal, Claas, Junghans, Matthias, Schroff, Sven A, König-Merediz, Carsten, Ziske, John, Strehl, Tilman, Sauerbruch, Burghardt, Wittig, Ingo G H, Schmidt-Wolf
Publikováno v:
In vivo (Athens, Greece). 21(1)
Viral and plasmid vectors may cause immunological side-effects resulting from the expression of therapeutically unwanted genes and from CpG motifs contained in their sequence. A new vector type for minimalistic, immunological-defined gene expression
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3532283c9f4b27e617ce924d3f04a1b3
https://pubmed.ncbi.nlm.nih.gov/17354609
https://pubmed.ncbi.nlm.nih.gov/17354609
Autor:
Javier de Cristobal, Burghardt Wittig, Bernadette Brzezicha, Astrid Sander, Manuel Schmidt, Sven A. König Merediz
Publikováno v:
Molecular Therapy. 13
Cytosine-guanine (CpG) motifs containing oligonucleotides (ODN) are commonly used for immunomodulatory purpose in cancer therapy and for the treatment of allergic diseases since they resemble bacterial DNA and serve as |[ldquo]|danger signals|[rdquo]
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53f15e8f2defa004a47a2832eb804ce0
Autor:
Joachim, Köchling, Sven A, König-Merediz, Renata, Stripecke, Dirk, Buchwald, Alexander, Korte, Hagen G, Von Einsiedel, Florian, Sack, Günter, Henze, Karl, Seeger, Burghardt, Wittig, Manuel, Schmidt
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 9(8)
Childhood Philadelphia chromosome positive (Ph(+)) acute lymphoblastic leukemia (ALL) has a poor prognosis. Because leukemia cell burden is reduced but not eradicated by polychemotherapy, improved treatment strategies should enhance those immune mech
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e639f9de19cd2e01bbfbe924b8493af4
https://pubmed.ncbi.nlm.nih.gov/12912966
https://pubmed.ncbi.nlm.nih.gov/12912966
Autor:
Sven A. König Merediz, Friedrich Hoffmann, Burghardt Wittig, Felix Schulte, Claas Junghans, Er-Ping Zhang, Anja Müller, Florian Sack
Publikováno v:
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie. 240(2)
Background: The beneficial effect of modulating an allospecific immune response by ballistic IL-4 and CTLA4 gene transfer to deliver minimalistic immunologically defined gene expression (MIDGE) vectors into the corneal epithelium was demonstrated in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c7f791ceca73bfcb76ef001acf5c606
https://pubmed.ncbi.nlm.nih.gov/11931076
https://pubmed.ncbi.nlm.nih.gov/11931076
Autor:
Burghardt Wittig, Sven A. König-Merediz, Ingo G.H. Schmidt-Wolf, Frank Schakowski, Björn Schöttker, Peter Buttgereit, Tilman Sauerbruch, Carsten Ziske, Matthias Schroff, Marcus Gorschlüter, Claas Junghans
Publikováno v:
Molecular therapy : the journal of the American Society of Gene Therapy. 3(5 Pt 1)
Viral and plasmid vectors may cause unwanted immunological side effects resulting from the expression of nontherapeutic genes contained in their sequence. Furthermore, replication-defective viral vectors carry the potential risk of recombination with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2abe155f72b800a742de44430d982b24
https://pubmed.ncbi.nlm.nih.gov/11356084
https://pubmed.ncbi.nlm.nih.gov/11356084
Autor:
Astrid Sander, Nicole Hagner, Juliana Köck, Manuel Schmidt, Sven A. König-Merediz, Burghardt Wittig
Publikováno v:
Molecular Therapy. 9:S244-S245
Linear, single-stranded oligonucleotide sequences (ODN) with unmethylated cytosine-guanine (CpG) motifs are immunomodulatory since they resemble bacterial DNA and serve as “danger signals”. These CpG-ODNs promote predominately a TH1-response, wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::806ad19050ecdf4fb89db1783fe924cc
https://doi.org/10.1016/j.ymthe.2004.06.588
https://doi.org/10.1016/j.ymthe.2004.06.588
Autor:
Renata Stripecke, Masoud Bahrami, Karl Seeger, Manuel Schmidt, Burghardt Wittig, Günter Henze, Sven A. König Merediz, Javier Prada, Joachim Köchling
Publikováno v:
Blood. 108:3262-3262
Although 70 – 80 % of children with childhood acute lymphoblastic leukemia (ALL) can be cured by poly-chemo-therapy, the prognosis of patients with Philadelphia chromosome positive (Ph+) ALL remains poor. Therefore, new relapse prevention strategie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::95fa96a7334a72dfc793e484bf283c6c
https://doi.org/10.1182/blood.v108.11.3262.3262
https://doi.org/10.1182/blood.v108.11.3262.3262
Autor:
Luisa Lopez-Fuertes, Marcos Timon, Manuel Schmidt, Matthias Schroff, Sven A. König-Merediz, Colin A. Smith, Antonio J. Vila-Coro, Sonia Moreno, Florian Sack, Burghardt Wittig
Publikováno v:
Molecular Therapy. 9:S309
Plasmid vectors currently used for DNA vaccination contain many sequences including antibiotic resistance genes which are not needed for the vaccine and that can potentially be dangerous for the host, i.e. in inducing allergic responses. We have deve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a14fa7c10059c93a09a5bd55a8751a0b
https://doi.org/10.1016/j.ymthe.2004.06.714
https://doi.org/10.1016/j.ymthe.2004.06.714