Zobrazeno 1 - 10
of 245
pro vyhledávání: '"Sven Nelander"'
Autor:
Ida Larsson, Felix Held, Gergana Popova, Alper Koc, Soumi Kundu, Rebecka Jörnsten, Sven Nelander
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Nervous system cancers exhibit diverse transcriptional cell states influenced by normal development, injury response, and growth. However, the understanding of these states’ regulation and pharmacological relevance remains limited. Here we
Externí odkaz:
https://doaj.org/article/4ec1fa55454340b1a41163e31467fa98
Autor:
Myrianni Constantinou, James Nicholson, Xinyu Zhang, Eleni Maniati, Sara Lucchini, Gabriel Rosser, Claire Vinel, Jun Wang, Yau Mun Lim, Sebastian Brandner, Sven Nelander, Sara Badodi, Silvia Marino
Publikováno v:
Cell Reports, Vol 43, Iss 6, Pp 114309- (2024)
Summary: Glioblastomas are the most common malignant brain tumors in adults; they are highly aggressive and heterogeneous and show a high degree of plasticity. Here, we show that methyltransferase-like 7B (METTL7B) is an essential regulator of lineag
Externí odkaz:
https://doaj.org/article/06de4fe6f43a439db3c5cbbb8e57eff6
Autor:
Iliana K Kerzeli, Martin Lord, Milena Doroszko, Ramy Elgendy, Aikaterini Chourlia, Ivan Stepanek, Elinor Larsson, Luuk van Hooren, Sven Nelander, Per-Uno Malmstrom, Anca Dragomir, Ulrika Segersten, Sara M Mangsbo
Publikováno v:
PLoS ONE, Vol 19, Iss 5, p e0304890 (2024)
[This corrects the article DOI: 10.1371/journal.pone.0253178.].
Externí odkaz:
https://doaj.org/article/1f097973f9f843c3a6e29a68ca4e0dba
Autor:
Emil Rosén, Hitesh Bhagavanbhai Mangukiya, Ludmila Elfineh, Rebecka Stockgard, Cecilia Krona, Philip Gerlee, Sven Nelander
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-12 (2023)
Abstract Cancer cell migration is a driving mechanism of invasion in solid malignant tumors. Anti-migratory treatments provide an alternative approach for managing disease progression. However, we currently lack scalable screening methods for identif
Externí odkaz:
https://doaj.org/article/66331ad2aa1046afad779c5e6db65f75
Autor:
Deniz Seçilmiş, Thomas Hillerton, Andreas Tjärnberg, Sven Nelander, Torbjörn E. M. Nordling, Erik L. L. Sonnhammer
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract The gene regulatory network (GRN) of a cell executes genetic programs in response to environmental and internal cues. Two distinct classes of methods are used to infer regulatory interactions from gene expression: those that only use observe
Externí odkaz:
https://doaj.org/article/79637b11433a4eada747b6b0a92cb23c
Autor:
Claire Vinel, Gabriel Rosser, Loredana Guglielmi, Myrianni Constantinou, Nicola Pomella, Xinyu Zhang, James R. Boot, Tania A. Jones, Thomas O. Millner, Anaelle A. Dumas, Vardhman Rakyan, Jeremy Rees, Jamie L. Thompson, Juho Vuononvirta, Suchita Nadkarni, Tedani El Assan, Natasha Aley, Yung-Yao Lin, Pentao Liu, Sven Nelander, Denise Sheer, Catherine L. R. Merry, Federica Marelli-Berg, Sebastian Brandner, Silvia Marino
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
The identification of patient-specific disease mechanisms and druggable targets is crucial for precision medicine in glioblastoma. Here, the authors show that comparing patients-matched glioma-initiating cells with neural stem cells enables the disco
Externí odkaz:
https://doaj.org/article/eef727b592d24a7697303fa96e18e608
Autor:
James Boot, Gabriel Rosser, Dailya Kancheva, Claire Vinel, Yau Mun Lim, Nicola Pomella, Xinyu Zhang, Loredana Guglielmi, Denise Sheer, Michael Barnes, Sebastian Brandner, Sven Nelander, Kiavash Movahedi, Silvia Marino
Publikováno v:
eLife, Vol 11 (2022)
We describe a subset of glioblastoma, the most prevalent malignant adult brain tumour, harbouring a bias towards hypomethylation at defined differentially methylated regions. This epigenetic signature correlates with an enrichment for an astrocytic g
Externí odkaz:
https://doaj.org/article/da3de84103274f4e822d1df1abc6378c
Autor:
Ida Larsson, Erika Dalmo, Ramy Elgendy, Mia Niklasson, Milena Doroszko, Anna Segerman, Rebecka Jörnsten, Bengt Westermark, Sven Nelander
Publikováno v:
Molecular Systems Biology, Vol 17, Iss 9, Pp 1-19 (2021)
Abstract Tumor cell heterogeneity is a crucial characteristic of malignant brain tumors and underpins phenomena such as therapy resistance and tumor recurrence. Advances in single‐cell analysis have enabled the delineation of distinct cellular stat
Externí odkaz:
https://doaj.org/article/65c2adc5f7ff4fcfb10d205bdc3d16b7
Publikováno v:
Frontiers in Genetics, Vol 13 (2022)
Accurate inference of gene regulatory networks (GRNs) is important to unravel unknown regulatory mechanisms and processes, which can lead to the identification of treatment targets for genetic diseases. A variety of GRN inference methods have been pr
Externí odkaz:
https://doaj.org/article/888bc8b91ca74d4ea7388d195c4ef1be
Autor:
Elin Almstedt, Ramy Elgendy, Neda Hekmati, Emil Rosén, Caroline Wärn, Thale Kristin Olsen, Cecilia Dyberg, Milena Doroszko, Ida Larsson, Anders Sundström, Marie Arsenian Henriksson, Sven Påhlman, Daniel Bexell, Michael Vanlandewijck, Per Kogner, Rebecka Jörnsten, Cecilia Krona, Sven Nelander
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
We lack effective treatment for half of children with high-risk neuroblastoma. Here, the authors introduce an algorithm that can predict the effect of interventions on gene expression signatures associated with high disease processes and risk, and id
Externí odkaz:
https://doaj.org/article/9eefbf3ff5bb4e6b9e9c8aacbd9a935c