Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Sven, Ruf"'
Autor:
Sven Ruf, Sridharan Rajagopal, Sanjay Venkatachalapathi Kadnur, Mahanandeesha S. Hallur, Shilpa Rani, Rajendra Kristam, Srinivasan Swaminathan, Bharat Ravindra Zope, Pavan Kumar Gondrala, Indu Swamy, V. P. Rama Kishore Putta, Saravanan Kandan, Gernot Zech, Herman Schreuder, Christine Rudolph, Ralf Elvert, Joerg Czech, Swarnakumari Birudukota, M. Amir Siddiqui, Niranjan Naranapura Anand, Vishal Subhash Mane, Sreekanth Dittakavi, Juluri Suresh, Ramachandraiah Gosu, Mullangi Ramesh, Takeshi Yura, Saravanakumar Dhakshinamoorthy, Aimo Kannt
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-18 (2022)
Abstract Nicotinamide N-methyltransferase (NNMT) is a metabolic regulator that catalyzes the methylation of nicotinamide (Nam) using the co-factor S-adenosyl-L-methionine to form 1-methyl-nicotinamide (MNA). Overexpression of NNMT and the presence of
Externí odkaz:
https://doaj.org/article/1bd53e86e70b4c66b07f2146adca9f2e
Autor:
Mathias Hohl, PhD, Katharina Erb, Lisa Lang, Sven Ruf, PhD, Thomas Hübschle, PhD, Stefan Dhein, MD, Wolfgang Linz, PhD, Adrian D. Elliott, PhD, Prashanthan Sanders, MBBS, PhD, Olesja Zamyatkin, Michael Böhm, MD, Ulrich Schotten, MD, PhD, Thorsten Sadowski, PhD, Dominik Linz, MD, PhD
Publikováno v:
JACC: Basic to Translational Science, Vol 4, Iss 3, Pp 332-344 (2019)
Summary: After myocardial infarction, remote ventricular remodeling and atrial cardiomyopathy progress despite successful revascularization. In a rat model of ventricular ischemia/reperfusion, pharmacological inhibition of the protease activity of ca
Externí odkaz:
https://doaj.org/article/557e934b169d490690787520b0553a6f
Autor:
Aimo Kannt, Sridharan Rajagopal, Mahanandeesha S. Hallur, Indu Swamy, Rajendra Kristam, Saravanakumar Dhakshinamoorthy, Joerg Czech, Gernot Zech, Herman Schreuder, Sven Ruf
Publikováno v:
Molecules, Vol 26, Iss 4, p 991 (2021)
Nicotinamide-N-methyltransferase (NNMT) is a cytosolic enzyme catalyzing the transfer of a methyl group from S-adenosyl-methionine (SAM) to nicotinamide (Nam). It is expressed in many tissues including the liver, adipose tissue, and skeletal muscle.
Externí odkaz:
https://doaj.org/article/61332a9f60cc407593eef5ac0b48e04f
Autor:
Lykourgos-Panagiotis Zalmas, Andrew Hercules, Melanie Schneider, Ian Dunham, David Ochoa, Andrew B. Benowitz, Markus A. Queisser, Sven Ruf, Veerabahu Shanmugasundaram, Andrew R. Leach, Kris Brown, Pamela Thomas, Gerhard Hessler, Chris J Radoux, Michael M. Hann
Publikováno v:
Nature Reviews Drug Discovery. 20:789-797
Proteolysis-targeting chimeras (PROTACs) are an emerging drug modality that may offer new opportunities to circumvent some of the limitations associated with traditional small-molecule therapeutics. By analogy with the concept of the 'druggable genom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6352b333275bbdb3ccd5a0b45fd0a6a5
https://doi.org/10.1038/s41573-021-00245-x
https://doi.org/10.1038/s41573-021-00245-x
Autor:
Patrick Shum, Thomas Licher, John L. Kane, Carolin Gerbeth-Kreul, Gerhard Hessler, Antje Pommereau, Sven Ruf, Christian Engel, Linli Wei, Joerg Czech, Theresa A Kuntzweiler
Publikováno v:
SLAS Discovery. 26:783-797
Classical high-throughput screening (HTS) technologies for the analysis of ionic currents across biological membranes can be performed using fluorescence-based, radioactive, and mass spectrometry (MS)-based uptake assays. These assays provide rapid r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::44e4fb083c4e35d492c537df0250e79a
https://doi.org/10.1177/24725552211011180
https://doi.org/10.1177/24725552211011180
Autor:
María Méndez, Gerhard Hessler, Ana Villar‐Garea, Angelika Weber, Patricia Fernandez-Rodriguez, Thomas Maier, Michael Kurz, Sven Ruf, Fabien Legros, Volker Derdau
Publikováno v:
European Journal of Organic Chemistry. 2021:782-787
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::25a49338f3db3f4978450137e9c157ad
https://doi.org/10.1002/ejoc.202001178
https://doi.org/10.1002/ejoc.202001178
Publikováno v:
Journal of Chemical Information and Modeling. 60:6120-6134
Mining the steadily increasing amount of chemical and biological data is a key challenge in drug discovery. Graph databases offer viable alternatives for capturing interrelationships between molecules and for generating novel insights for design. In
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9baa09c90daecabcc2cb99201ce286d6
https://doi.org/10.1021/acs.jcim.0c00947
https://doi.org/10.1021/acs.jcim.0c00947
Autor:
Michael Böhm, Jan-Christian Reil, Manuel Mayr, Christoph Maack, Thomas Hübschle, Thorsten Sadowski, Alexander Nickel, Claudia Goettsch, Benedikt Linz, Sven Ruf, Thimoteus Speer, Dominik Linz, Simina-Ramona Selejan, Javier Barallobre-Barreiro, Xiaoke Yin, Claudia Fecher-Trost, Lisa Lang, Katharina Erb, Mathias Hohl
Publikováno v:
Journal of Biological Chemistry, 295(36), 12605-12617. American Society for Biochemistry and Molecular Biology, Inc.
Hohl, M, Mayr, M, Lang, L, Nickel, A G, Barallobre-Barreiro, J, Yin, X, Speer, T, Selejan, S-R, Goettsch, C, Erb, K, Fecher-Trost, C, Reil, J-C, Linz, B, Ruf, S, Huebschle, T, Maack, C, Boehm, M, Sadowski, T & Linz, D 2020, ' Cathepsin A contributes to left ventricular remodeling by degrading extracellular superoxide dismutase in mice ', Journal of Biological Chemistry, vol. 295, no. 36, pp. 12605-12617 . https://doi.org/10.1074/jbc.RA120.013488
J Biol Chem
Hohl, M, Mayr, M, Lang, L, Nickel, A G, Barallobre-Barreiro, J, Yin, X, Speer, T, Selejan, S-R, Goettsch, C, Erb, K, Fecher-Trost, C, Reil, J-C, Linz, B, Ruf, S, Huebschle, T, Maack, C, Boehm, M, Sadowski, T & Linz, D 2020, ' Cathepsin A contributes to left ventricular remodeling by degrading extracellular superoxide dismutase in mice ', Journal of Biological Chemistry, vol. 295, no. 36, pp. 12605-12617 . https://doi.org/10.1074/jbc.RA120.013488
J Biol Chem
In the heart, the serine carboxypeptidase cathepsin A (CatA) is distributed between lysosomes and the extracellular matrix (ECM). CatA-mediated degradation of extracellular peptides may contribute to ECM remodeling and left ventricular (LV) dysfuncti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::924f30ce6602efb1085a9f0d1292fe74
https://cris.maastrichtuniversity.nl/en/publications/ff966c47-ec5e-4d2e-bb3d-0ec7bd139a1b
https://cris.maastrichtuniversity.nl/en/publications/ff966c47-ec5e-4d2e-bb3d-0ec7bd139a1b
Autor:
John D. Herszman, Yuji Kurimoto, Sven Ruf, Siegfried R. Waldvogel, Goswinus H. M. de Kruijff, Aaron Schüll, Michael Berger
Publikováno v:
Chemical Science
Electrochemical decarboxylation of aryloxyacetic acids followed by fluorination provides easy access to fluoromethyl aryl ethers. This electrochemical fluorodecarboxylation offers a sustainable approach with electric current as traceless oxidant. Usi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3eb31b7368895c4c2cc9eab34a830d0f
https://doi.org/10.1039/d0sc02417a
https://doi.org/10.1039/d0sc02417a
Autor:
Christoffer Laustsen, Thorsten Sadowski, Sven Ruf, Esben Søvsø Szocska Hansen, Lotte Bonde Bertelsen
Publikováno v:
Bertelsen, L B, Hansen, E S S, Sadowski, T, Ruf, S & Laustsen, C 2021, ' Hyperpolarized pyruvate to measure the influence of PKM2 activation on glucose metabolism in the healthy kidney ', NMR in Biomedicine, vol. 34, no. 11, e4583 . https://doi.org/10.1002/nbm.4583
The purpose of the current study was to investigate if hyperpolarized [1-C-13]pyruvate can inform us on the metabolic consequences for the kidney glucose metabolism upon treatment with the pyruvate kinase M2 (PKM2) activator TEPP-46, which has shown
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6217ebf4c8e4d1cc698c5e6d36235216
https://pure.au.dk/portal/da/publications/hyperpolarized-pyruvate-to-measure-the-influence-of-pkm2-activation-on-glucose-metabolism-in-the-healthy-kidney(7e0032a4-2646-4198-99dd-780436d6f4ca).html
https://pure.au.dk/portal/da/publications/hyperpolarized-pyruvate-to-measure-the-influence-of-pkm2-activation-on-glucose-metabolism-in-the-healthy-kidney(7e0032a4-2646-4198-99dd-780436d6f4ca).html
