Zobrazeno 1 - 10
of 516
pro vyhledávání: '"Sven, Perner"'
Autor:
Franz F. Dressler, Falk Diedrichs, Deema Sabtan, Sofie Hinrichs, Christoph Krisp, Timo Gemoll, Martin Hennig, Paulina Mackedanz, Mareile Schlotfeldt, Hannah Voß, Anne Offermann, Jutta Kirfel, Marie C. Roesch, Julian P. Struck, Mario W. Kramer, Axel S. Merseburger, Christian Gratzke, Dominik S. Schoeb, Arkadiusz Miernik, Hartmut Schlüter, Ulrich Wetterauer, Roman Zubarev, Sven Perner, Philipp Wolf, Ákos Végvári
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Urothelial bladder cancer (UC) has a wide tumor biological spectrum with challenging prognostic stratification and relevant therapy-associated morbidity. Most molecular classifications relate only indirectly to the therapeutically relevant p
Externí odkaz:
https://doaj.org/article/5134170881c84f2485111eb97cd4a685
Autor:
Helen Pasternack, Mirjam Polzer, Timo Gemoll, Christiane Kümpers, Thorben Sauer, Pamela Lazar-Karsten, Sofie Hinrichs, Sabine Bohnet, Sven Perner, Franz Friedrich Dressler, Jutta Kirfel
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract Lung cancer is the leading cause of cancer-related deaths worldwide with lung adenocarcinoma (LUAD) being the most common type. Genomic studies of LUAD have advanced our understanding of its tumor biology and accelerated targeted therapy. Ho
Externí odkaz:
https://doaj.org/article/09d107fdcd3c4d4cba2df94ebd3ea219
Autor:
Mustafa Abdo, Yassine Belloum, David Heigener, Lutz Welker, Sönke vonWeihe, Milena Schmidt, Nadine Heuer‐Olewinski, Iris Watermann, Marlen Szewczyk, Jolanthe Kropidlowski, Thais Pereira‐Veiga, Hatice Elmas, Sven Perner, Stefan Steurer, Harriet Wikman, Klaus Pantel, Martin Reck
Publikováno v:
Molecular Oncology, Vol 17, Iss 5, Pp 737-746 (2023)
Alternative sources of tumour information need to be explored in patients with non‐small cell lung cancer (NSCLC). Here, we compared programmed cell death ligand 1 (PD‐L1) expression on cytology imprints and circulating tumour cells (CTCs) with P
Externí odkaz:
https://doaj.org/article/5f86dcedcf5f4cf3aad21b856a6d9805
Autor:
Alireza Saraji, Katharina Wulf, Janine Stegmann-Frehse, Duan Kang, Anne Offermann, Danny Jonigk, Mark Philipp Kuehnel, Jutta Kirfel, Sven Perner, Verena Wilbeth Sailer
Publikováno v:
PLoS ONE, Vol 19, Iss 8, p e0306525 (2024)
Metastatic prostate cancer (mPCa) is a widespread disease with high mortality. Unraveling molecular mechanisms of disease progression is of utmost importance. The microenvironment in visceral organs and the skeletal system is of particular interest a
Externí odkaz:
https://doaj.org/article/33797f9367fc4006a1d146fed03bd29a
Autor:
Sandra Genduso, Vera Freytag, Daniela Schetler, Lennart Kirchner, Alina Schiecke, Hanna Maar, Daniel Wicklein, Florian Gebauer, Katharina Bröker, Christine Stürken, Karin Milde-Langosch, Leticia Oliveira-Ferrer, Franz L. Ricklefs, Florian Ewald, Gerrit Wolters-Eisfeld, Kristoffer Riecken, Ludmilla Unrau, Linda Krause, Hanibal Bohnenberger, Anne Offermann, Sven Perner, Susanne Sebens, Katrin Lamszus, Linda Diehl, Stefan Linder, Manfred Jücker, Udo Schumacher, Tobias Lange
Publikováno v:
Journal of Hematology & Oncology, Vol 16, Iss 1, Pp 1-24 (2023)
Abstract Background The immunological composition of the tumor microenvironment has a decisive influence on the biological course of cancer and is therefore of profound clinical relevance. In this study, we analyzed the cooperative effects of integri
Externí odkaz:
https://doaj.org/article/15a2e60098c04388b2f1c864ee3b2031
Autor:
Philipp Jurmeister, Stefanie Glöß, Renée Roller, Maximilian Leitheiser, Simone Schmid, Liliana H. Mochmann, Emma Payá Capilla, Rebecca Fritz, Carsten Dittmayer, Corinna Friedrich, Anne Thieme, Philipp Keyl, Armin Jarosch, Simon Schallenberg, Hendrik Bläker, Inga Hoffmann, Claudia Vollbrecht, Annika Lehmann, Michael Hummel, Daniel Heim, Mohamed Haji, Patrick Harter, Benjamin Englert, Stephan Frank, Jürgen Hench, Werner Paulus, Martin Hasselblatt, Wolfgang Hartmann, Hildegard Dohmen, Ursula Keber, Paul Jank, Carsten Denkert, Christine Stadelmann, Felix Bremmer, Annika Richter, Annika Wefers, Julika Ribbat-Idel, Sven Perner, Christian Idel, Lorenzo Chiariotti, Rosa Della Monica, Alfredo Marinelli, Ulrich Schüller, Michael Bockmayr, Jacklyn Liu, Valerie J. Lund, Martin Forster, Matt Lechner, Sara L. Lorenzo-Guerra, Mario Hermsen, Pascal D. Johann, Abbas Agaimy, Philipp Seegerer, Arend Koch, Frank Heppner, Stefan M. Pfister, David T. W. Jones, Martin Sill, Andreas von Deimling, Matija Snuderl, Klaus-Robert Müller, Erna Forgó, Brooke E. Howitt, Philipp Mertins, Frederick Klauschen, David Capper
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Sinonasal tumour diagnosis can be complicated by the heterogeneity of disease and classification systems. Here, the authors use machine learning to classify sinonasal undifferentiated carcinomas into 4 molecular classe with differences in differentia
Externí odkaz:
https://doaj.org/article/6b6e398cca1d45b0ab123d7e7294892a
Autor:
Isabel Heidegger, Georgios Fotakis, Anne Offermann, Jermaine Goveia, Sophia Daum, Stefan Salcher, Asma Noureen, Hetty Timmer-Bosscha, Georg Schäfer, Annemiek Walenkamp, Sven Perner, Aleksandar Beatovic, Matthieu Moisse, Christina Plattner, Anne Krogsdam, Johannes Haybaeck, Sieghart Sopper, Stefanie Thaler, Markus A. Keller, Helmut Klocker, Zlatko Trajanoski, Dominik Wolf, Andreas Pircher
Publikováno v:
Molecular Cancer, Vol 21, Iss 1, Pp 1-20 (2022)
Abstract Background Crosstalk between neoplastic and stromal cells fosters prostate cancer (PCa) progression and dissemination. Insight in cell-to-cell communication networks provides new therapeutic avenues to mold processes that contribute to PCa t
Externí odkaz:
https://doaj.org/article/3611b9c2fa1d4e1088f9050c913e7e3d
Aggressive variants of prostate cancer: underlying mechanisms of neuroendocrine transdifferentiation
Autor:
Lina Merkens, Verena Sailer, Davor Lessel, Ella Janzen, Sarah Greimeier, Jutta Kirfel, Sven Perner, Klaus Pantel, Stefan Werner, Gunhild von Amsberg
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 41, Iss 1, Pp 1-20 (2022)
Abstract Prostate cancer is a hormone-driven disease and its tumor cell growth highly relies on increased androgen receptor (AR) signaling. Therefore, targeted therapy directed against androgen synthesis or AR activation is broadly used and continual
Externí odkaz:
https://doaj.org/article/af616c4e41df4e3faad5f2ada80aa9e5
Autor:
Anna Cirkel, Klaus-Peter Wandinger, Claudia Ditz, Jan Leppert, Lars Hanker, Christoph Cirkel, Alexander Neumann, Jan Brocke, Romana Höftberger, Lars Komorowski, Sven Perner, Frank Leypoldt, Tobias Wagner-Altendorf, Thomas F. Münte, Georg Royl
Publikováno v:
Neurological Research and Practice, Vol 3, Iss 1, Pp 1-7 (2021)
Abstract Background Recently, antibodies against the alpha isoform of the glial-fibrillary-acidic-protein (GFAPα) were identified in a small series of patients with encephalomyelitis. Coexisting autoantibodies (NMDA receptor, GAD65 antibodies) have
Externí odkaz:
https://doaj.org/article/1c434f4d0b824aaaa5b6dcdc13d37f1a
Autor:
Christiane Kuempers, Tobias Jagomast, Carsten Heidel, Finn-Ole Paulsen, Sabine Bohnet, Stefanie Schierholz, Eva Dreyer, Jutta Kirfel, Sven Perner
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
AimNon-small cell lung cancer (NSCLC) remains the leading cause of cancer-related death globally despite promising progress of personalized therapy approaches. Cyclin-dependent kinase 7 (CDK7) is a kinase involved in transcription, overexpressed in a
Externí odkaz:
https://doaj.org/article/71d17770ef834831a4c56252dcf835ed