Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Sven, Lang"'
Autor:
Chevallier, Patrick, Wigmore, Stephen, Newhook, Timothy, Vauthey, Jean-Nicolas, Memeo, Riccardo, Dasari, Bobby VM., Braunwarth, Eva, Aldrighetti, Luca, Andorrà, Esteban Cugat, Arntz, Pieter, Arslan, Bulent, van Baardewijk, Laurens, Baclija, Ivan, Ball, Chad, Barbier, Louise, Bednarsch, Jan, Bemelmans, Marc, Bent, Clare, van den Bergh, Frans, Billingsley, Kevin, Binkert, Christoph, Björnsson, Bergthor, de Boer, Marieke T., Bokkers, Reinoud P.H., de Boo, Diederick, Garcia Borobia, Francisco Javier, Braat, Dries, Breen, David, Breitenstein, Stefan, Brousseau, Karine, Bruijnen, Ruther, Bruners, Philipp, Bruns, Christiane, Bunck, Alexander, Burgmans, Mark, Cappelli, Alberta, Carling, Ulrik, de Carvalho, Luis Abreu, Cha, Charles, Chan, Benjamin, Chand, Belinda, Chapelle, Thiery, De Cobelli, Franceso, Coubeau, Laurent, Criado, Eva, Croagh, Daniel, D'Hondt, Mathieu, van Dam, Ronald, Damink, Steven Olde, Davis, Rob, Delle, Martin, Denys, Alban, Deprez, Fabrice, Detry, Olivier, Dewulf, Maxime, Dili, Alexandra, Dixon, Matthew, Díaz-Nieto, Rafael, Erdmann, Joris I., Fernando, Rukshan, Font, Jaume Codina, Fouraschen, Suomi, François, Olivier, Fretland, Åsmund A., Fundora, Yilian, Gadani, Sameer, Gallinger, Steven, Geleabert, Alexandra, Gerard, Laurent, Giménez, Josep Guitart, Gobardhan, Paul, Goffette, Pierre, Grochola, Lukasz Filip, Gruenberger, Thomas, Grünhagen, Dirk, Guiliante, Felice, Gómez, Fernando, Hagendoorn, Jeroen, Hammond, John, Heijmans, Margot, Heil, Jan, Heise, Daniel, Laurens Hermie, Herrero, Eric, Hess, Gebriel, Heye, Sam, Hoffmann, Martin, Iezzi, Roberto, Imani, Farshad, James, Sinead, Jardinet, Thomas, Joshi, Kunal, Jovine, Elio, Kalil, Jennifer, Karanicolas, Paul, Kazemier, Geert, Kern, Lars, Kingham, Peter, Klass, Darren, Koerkamp, Bas Groot, Kollmar, Otto, Korenblik, Remon, Choon Kwon, Céline Lambrecht, Sven Lang, Laura-Ann, Leclercq, Wouter, van der Leij, Christiaan, Lindsay, Richard, Lopez-Ben, Santiago, Lucidi, Valerio, López, Jordi Navinés, Macdonald, Andrew, Madoff, David C., Markose, George, Maroune, Gilbert, Martel, Guillaume, Martin, Ernesto Santos, Mehrzad, Homoyon, Meijerink, Martijn, Melloul, Emmanuel, Messaoudi, Nouredin, Metrakos, Peter, Modi, Sachin, Montanari, Nicola, Moragues, Jaume Sampere, Mujoomdar, Amol, Neumann, Ulf, Oor, Jelmer, Pappas, Patroklos, Pieterman, Kay, Primrose, John, Qu, Xudong, Ratti, Francesca, Ridouani, Fourat, Borel Rinkes, Inne H.M., Casellas i Robert, Margarida, Ross, Steffen, Ruo, Leyo, Ryan, Stephen, Salik, Aysun, Sandström, Per, Santol, Jonas, Sarría, Luis, Schaarschmidt, Benedikt, Schadde, Erik, Schiesser, Marc, Schmelzle, Moritz, Seeger, Nico, Segedi, Maja, Serenari, Matteo, Gregory Sergeant, Serrablo, Alejandro, Simon, Sorina, Skaro, Anton, Smits, Maarten, Smits, Jens, Snitzbauer, Andreas, Soonawalla, Zahir, Sparrelid, Ernesto, Spuentrup, Elmar, Stavrou, Gregor, Sutcliffe, Robert, Swijnenburg, Rutger-Jan, Tancredi, Ilario, Tasse, Jordan C., Tschögl, Madita, Udupa, Venkatesha, Valenti, David A., Vass, David, van der Velden, Ariadne Lisa, Vogl, Thomas, Wacker, Frank, Wang, Xiaoying, Weitz, Jürgen, White, Steven, Widyaningsih, Rizky, De Wispelaere, Jean-François, Zijlstra, Ijsbrand, Chau, Steven, James, Sinéad, Abreu de Carvalho, Luis, Erdmann, Joris, Hermie, Laurens, van Dam, Ronald M.
Publikováno v:
In HPB December 2024 26(12):1458-1466
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
In human cells, approximately 30% of all polypeptides enter the secretory pathway at the level of the endoplasmic reticulum (ER). This process involves cleavable amino-terminal signal peptides (SPs) or more or less amino-terminal transmembrane helice
Externí odkaz:
https://doaj.org/article/1a2f57b3c5b64bdfae3c88d8795477ed
Autor:
Lara Heij, Jan Bednarsch, Xiuxiang Tan, Mika Rosin, Simone Appinger, Konrad Reichel, Dana Pecina, Michail Doukas, Ronald M. van Dam, Juan Garcia Vallejo, Florian Ulmer, Sven Lang, Tom Luedde, Flavio G. Rocha, Shivan Sivakumar, Ulf Peter Neumann
Publikováno v:
Cells, Vol 12, Iss 6, p 851 (2023)
Background: The tumor microenvironment (TME) in cholangiocarcinoma (CCA) influences the immune environment. Checkpoint blockade is promising, but reliable biomarkers to predict response to treatment are still lacking. Materials and Methods: The level
Externí odkaz:
https://doaj.org/article/68ffcc0262fb428491c574a8120ce0c8
Autor:
Andrea Tirincsi, Sarah O’Keefe, Duy Nguyen, Mark Sicking, Johanna Dudek, Friedrich Förster, Martin Jung, Drazena Hadzibeganovic, Volkhard Helms, Stephen High, Richard Zimmermann, Sven Lang
Publikováno v:
Cells, Vol 11, Iss 18, p 2925 (2022)
Importing proteins into the endoplasmic reticulum (ER) is essential for about 30% of the human proteome. It involves the targeting of precursor proteins to the ER and their insertion into or translocation across the ER membrane. Furthermore, it relie
Externí odkaz:
https://doaj.org/article/7a37f1d3fb0d44a199e6750c851b2c65
Autor:
Julia SM Zimmermann, Annika Cullmann, Askin Kaya, Merle Doerk, Maximilian Linxweiler, Marc P Radosa, Sven Lang, Martin Jung, Erich F Solomayer, Julia C Radosa
Publikováno v:
Cancer Research. 83:P6-14
Background Chromosome 3q26 amplifications represent a frequent alteration in various cancer entities including breast cancer. SEC62 – a 3q26 encoded gene – was identified as a potential onco- and tumor-driver gene for the pathogenesis of breast c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::26b9fe0e7227f39056fb36796bf8057d
https://doi.org/10.1158/1538-7445.sabcs22-p6-14-18
https://doi.org/10.1158/1538-7445.sabcs22-p6-14-18
Publikováno v:
Data in Brief, Vol 31, Iss , Pp 105931- (2020)
The Prion protein (PrP) is a highly conserved cell surface glycoprotein. To enter the secretory pathway, the PrP precursor relies on the Sec61 complex and multiple accessory factors all gathering at the membrane of the Endoplasmic reticulum (ER). PrP
Externí odkaz:
https://doaj.org/article/39b6b27a4d4346c0a4a5d502ecbcd7f3
Autor:
Richard Zimmermann, Sven Lang
Publikováno v:
Contact, Vol 3 (2020)
Pioneering work in the 1990s started to address an interesting question. How is the main cellular energy source, adenosine triphosphate (ATP), imported into the mammalian endoplasmic reticulum (ER)? Despite its high-energy demand, large volume, and s
Externí odkaz:
https://doaj.org/article/727eb985aa874b71a14439fb72d9e5e7
Autor:
Duy Nguyen, Regine Stutz, Stefan Schorr, Sven Lang, Stefan Pfeffer, Hudson H. Freeze, Friedrich Förster, Volkhard Helms, Johanna Dudek, Richard Zimmermann
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
While Sec61 enables ER import of all polypeptides with N-terminal signal peptides, only selected clients are accepted for TRAP-assisted ER import. Here, the authors use a proteomics approach to characterize TRAP-dependent clients, identifying signal
Externí odkaz:
https://doaj.org/article/ccdad44d8b644ceabe5c045b8a8b8350
Autor:
Marie-Christine Klein, Katharina Zimmermann, Stefan Schorr, Martina Landini, Patrick A. W. Klemens, Jacqueline Altensell, Martin Jung, Elmar Krause, Duy Nguyen, Volkhard Helms, Jens Rettig, Claudia Fecher-Trost, Adolfo Cavalié, Markus Hoth, Ivan Bogeski, H. Ekkehard Neuhaus, Richard Zimmermann, Sven Lang, Ilka Haferkamp
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Endoplasmic reticulum (ER) functioning requires a constant supply of ATP, but the exchanger required for ATP uptake into the ER is unknown. Here, the authors report that SLC35B1, here named AXER, or ATP/ADP exchanger into the ER, can transport ATP in
Externí odkaz:
https://doaj.org/article/ac526f2764c44504b8828f5d643e6d8d
Autor:
Sven Lang, Tyler A Hilsabeck, Kenneth A Wilson, Amit Sharma, Neelanjan Bose, Deanna J Brackman, Jennifer N Beck, Ling Chen, Mark A Watson, David W Killilea, Sunita Ho, Arnold Kahn, Kathleen Giacomini, Marshall L Stoller, Thomas Chi, Pankaj Kapahi
Publikováno v:
PLoS Genetics, Vol 15, Iss 8, p e1008318 (2019)
Elevated uric acid (UA) is a key risk factor for many disorders, including metabolic syndrome, gout and kidney stones. Despite frequent occurrence of these disorders, the genetic pathways influencing UA metabolism and the association with disease rem
Externí odkaz:
https://doaj.org/article/8215a5e6533541639565d4c0aab3138d