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Akademický článek

Targeting TGF-ß in the Central Nervous System: Assessment of Cynomolgus Monkey—Toxicity and Pharmacokinetics for an LNA-Antisense Oligonucleotide

Autor: Sebastian Peters, Eva Wirkert, Sabrina Kuespert, Rosmarie Heydn, Sven Korte, Lars Mecklenburg, Ludwig Aigner, Siw Johannesen, Tim-Henrik Bruun, Ulrich Bogdahn

Publikováno v: Applied Sciences, Vol 12, Iss 3, p 973 (2022)

Increasingly antisense oligonucleotides (ASOs) are developed for potential treatment of CNS disorders, and due to the inability to cross the blood brain barrier, they require direct administration into the cerebrospinal fluid (CSF). In this regard, i

Externí odkaz: https://doaj.org/article/4027f861493a47a29d8001e8f86f1eb9

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Akademický článek

Safe and Effective Cynomolgus Monkey GLP—Tox Study with Repetitive Intrathecal Application of a TGFBR2 Targeting LNA-Gapmer Antisense Oligonucleotide as Treatment Candidate for Neurodegenerative Disorders

Autor: Sebastian Peters, Eva Wirkert, Sabrina Kuespert, Rosmarie Heydn, Siw Johannesen, Anita Friedrich, Susanne Mailänder, Sven Korte, Lars Mecklenburg, Ludwig Aigner, Tim-Henrik Bruun, Ulrich Bogdahn

Publikováno v: Pharmaceutics, Vol 14, Iss 1, p 200 (2022)

The capability of the adult central nervous system to self-repair/regenerate was demonstrated repeatedly throughout the last decades but remains in debate. Reduced neurogenic niche activity paralleled by a profound neuronal loss represents fundamenta

Externí odkaz: https://doaj.org/article/2be091cb44884b99a0ace5ee62d10f3a

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Save Your Maximum Tolerated Dose: How to Diagnose Procedure-Related Spinal Cord Lesions After Lumbar Intrathecal Bolus Administration of Oligonucleotides in Cynomolgus Monkeys

Autor: Magdalena Wozniak, Jorge Luft, Peter Korytko, F. Runge, Serge Zander, Lars Mecklenburg, Anne von Keutz, Florian Timo Ludwig, Betina Pajaziti, Annette Romeike, Sven Korte

Publikováno v: International Journal of Toxicology. 39:510-517

Many potential drugs for treatment of neurodegenerative diseases, particularly antisense oligonucleotides (ASOs), are administered via lumbar intrathecal injection, because these drugs do not cross the blood–brain barrier. Intrathecal injection is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::117e5caab55e193558a555cfe058c512
https://doi.org/10.1177/1091581820951098

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Reconditioning the Neurogenic Niche of Adult Non-human Primates by Antisense Oligonucleotide-Mediated Attenuation of TGFβ Signaling

Publikováno v: Neurotherapeutics 18(3), 1963-1979 (2021). doi:10.1007/s13311-021-01045-2
Neurotherapeutics
Neurotherapeutics : official journal of the American Society for Experimental NeuroTherapeutics (ASENT) 18(3), 1963-1979 (2021). doi:10.1007/s13311-021-01045-2

Neurotherapeutics : official journal of the American Society for Experimental NeuroTherapeutics (ASENT) 18(3), 1963-1979 (2021). doi:10.1007/s13311-021-01045-2
Published by Springer, New York, NY

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a720507a761d33ae4f93f9fa50bdf546

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Range of Neurological Signs in Cynomolgus Monkeys After Intrathecal Bolus Administration of Antisense Oligonucleotides

Autor: Daniela Smieja, Florian Timo Ludwig, F. Runge, Sven Korte, Peter Korytko, Lars Mecklenburg, Magdalena Wozniak

Publikováno v: International journal of toxicology. 39(6)

Intrathecal (IT) dosing (ie, injection into the subarachnoidal space at the lumbar region) is a common route of administration in cynomolgus monkey preclinical safety studies conducted for antisense oligonucleotides (ASO) that target central nervous

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::032a7b141bfa328a0ed77a1a2a8b18b3
https://pubmed.ncbi.nlm.nih.gov/32794413

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Feasibility of intravitreal injections and ophthalmic safety assessment in marmoset (Callithrix jacchus) monkeys

Autor: Keith Mansfield, Marilyn Hill, Andrew Pilling, Lars Mecklenburg, Sven Korte, Stephanie Fridrichs-Gromoll, Jan Kremers, Jenny Atorf, Birgit Korbmacher, Andreas Wiederhold

To safeguard patients, regulatory authorities require that new drugs that are to be given by the intravitreal (IVT) route are assessed for their safety in a laboratory species using the same route of administration. Due to the high similarity of ocul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f79430c05b4594c8e677a6b2c0558d0c
https://www.primate-biol.net/4/93/2017/

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Differential responses to JNJ-37822681, a specific and fast dissociating dopamine D2 receptor antagonist, in cynomolgus monkey and Sprague-Dawley rat general toxicology studies: clinical observations, prolactin levels, mammary histopathology findings and

Autor: Marc Niehoff, Kevan Chase, Sven Korte, Eric J. de Waal, Ann Lampo, Wayne Arrowsmith, Maria Desmidt

Publikováno v: Journal of Applied Toxicology. 34:974-992

JNJ-37822681 is a potent, specific and fast dissociating dopamine D2 receptor antagonist intended for the treatment of schizophrenia. Its nonclinical toxicological profile was investigated in a series of general repeat dose toxicity studies in cynomo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d8dfbfe5d9ca3d59e6dce337355c97c
https://doi.org/10.1002/jat.2916

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Elektronická kniha

The Nonhuman Primate in Nonclinical Drug Development and Safety Assessment

Autor: Joerg Bluemel, Sven Korte, Emanuel Schenck, Gerhard Weinbauer

The Nonhuman Primate in Drug Development and Safety Assessment is a valuable reference dedicated to compiling the latest research on nonhuman primate models in nonclinical safety assessment, regulatory toxicity testing and translational science. By c

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