Zobrazeno 1 - 10
of 132
pro vyhledávání: '"Sven, Enerbäck"'
Autor:
Prasanna K.R. Allu, Maria Dafne Cardamone, Antonio S. Gomes, Alessandra Dall'agnese, Carly Cederquist, Hui Pan, Jonathan M. Dreyfuss, Sven Enerbäck, C. Ronald Kahn
Publikováno v:
Molecular Metabolism, Vol 78, Iss , Pp 101825- (2023)
Objective: Insulin acts on the liver via changes in gene expression to maintain glucose and lipid homeostasis. This study aimed to the Forkhead box protein K1 (FOXK1) associated gene regulatory network as a transcriptional regulator of hepatic insuli
Externí odkaz:
https://doaj.org/article/d2e1cc8bad99432488ec8c7abd957cfd
Autor:
Masaji Sakaguchi, Weikang Cai, Chih-Hao Wang, Carly T. Cederquist, Marcos Damasio, Erica P. Homan, Thiago Batista, Alfred K. Ramirez, Manoj K. Gupta, Martin Steger, Nicolai J. Wewer Albrechtsen, Shailendra Kumar Singh, Eiichi Araki, Matthias Mann, Sven Enerbäck, C. Ronald Kahn
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
Insulin signaling represses Forkhead transcription factor FoxO activity, which contributes to organismal metabolism. Here, the authors use proteomics to identify positively regulated insulin signaling targets FoxK1/K2 and demonstrate their role in li
Externí odkaz:
https://doaj.org/article/6452f44069924205846a1027bdcd7038
Autor:
David Lasar, Matthias Rosenwald, Elke Kiehlmann, Miroslav Balaz, Bettina Tall, Lennart Opitz, Martin E. Lidell, Nicola Zamboni, Petra Krznar, Wenfei Sun, Lukas Varga, Patrik Stefanicka, Jozef Ukropec, Pirjo Nuutila, Kirsi Virtanen, Ez-Zoubir Amri, Sven Enerbäck, Walter Wahli, Christian Wolfrum
Publikováno v:
Cell Reports, Vol 22, Iss 3, Pp 760-773 (2018)
Peroxisome proliferator-activated receptors (PPARs) have been suggested as the master regulators of adipose tissue formation. However, their role in regulating brown fat functionality has not been resolved. To address this question, we generated mice
Externí odkaz:
https://doaj.org/article/ee83d2e8cd0648b6a7bef8f918477378
Autor:
Katarina Klepac, Ana Kilić, Thorsten Gnad, Loren M. Brown, Beate Herrmann, Andrea Wilderman, Aileen Balkow, Anja Glöde, Katharina Simon, Martin E. Lidell, Matthias J. Betz, Sven Enerbäck, Jürgen Wess, Marc Freichel, Matthias Blüher, Gabi König, Evi Kostenis, Paul A. Insel, Alexander Pfeifer
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
Brown and beige adipose tissues contribute to organismal energy expenditure by generating heat. Here, Klepac et al. survey G protein-coupled receptors in brown fat and show that Gq-coupled receptors inhibit expression of thermogenic proteins in mice
Externí odkaz:
https://doaj.org/article/7a2bc9f5eaee4df68bf0b1b7a219eba3
Autor:
Aliki Perdikari, Germán Gastón Leparc, Miroslav Balaz, Nuno D. Pires, Martin E. Lidell, Wenfei Sun, Francesc Fernandez-Albert, Sebastian Müller, Nassila Akchiche, Hua Dong, Lucia Balazova, Lennart Opitz, Eva Röder, Holger Klein, Patrik Stefanicka, Lukas Varga, Pirjo Nuutila, Kirsi A. Virtanen, Tarja Niemi, Markku Taittonen, Gottfried Rudofsky, Jozef Ukropec, Sven Enerbäck, Elia Stupka, Heike Neubauer, Christian Wolfrum
Publikováno v:
Cell Reports, Vol 25, Iss 3, Pp 784-797.e4 (2018)
Summary: Recruitment and activation of thermogenic adipocytes have received increasing attention as a strategy to improve systemic metabolic control. The analysis of brown and brite adipocytes is complicated by the complexity of adipose tissue biopsi
Externí odkaz:
https://doaj.org/article/e91244b87ff84ba1bb8eb4ec6ba835f6
Autor:
Haixia Ma, Valentina Sukonina, Wei Zhang, Fang Meng, Santhilal Subhash, Henrik Palmgren, Ida Alexandersson, Huiming Han, Shuping Zhou, Stefano Bartesaghi, Chandrasekhar Kanduri, Sven Enerbäck
Publikováno v:
Journal of Biological Chemistry. :104795
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::af4211128cdb8bcb24d5b49f4277bd0a
https://doi.org/10.1016/j.jbc.2023.104795
https://doi.org/10.1016/j.jbc.2023.104795
Autor:
Jarna C. Hannukainen, Keijo T Mäkelä, Sauli Piirola, Vesa Oikonen, Sven Enerbäck, Pirjo Nuutila, Tam Pham, Riku Kiviranta, Martin E. Lidell, Kirsi A. Virtanen, Riitta Parkkola, Kaisa K. Ivaska
Publikováno v:
The Journal of Clinical Endocrinology and Metabolism
ContextBone marrow (BM) in adult long bones is rich in adipose tissue, but the functions of BM adipocytes are largely unknown. We set out to elucidate the metabolic and molecular characteristics of BM adipose tissue (BMAT) in humans.ObjectiveOur aim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69056d6b07296fd06a6b66ea48addce8
https://doi.org/10.1210/clinem/dgaa216
https://doi.org/10.1210/clinem/dgaa216
Autor:
Thiago M. Batista, C. Ronald Kahn, Alfred K. Ramirez, Eiichi Araki, Martin Steger, Weikang Cai, Shailendra Kumar Singh, Nicolai J. Wewer Albrechtsen, Marcos Damasio, Matthias Mann, Manoj K. Gupta, Erica P. Homan, Masaji Sakaguchi, Chih-Hao Wang, Carly T. Cederquist, Sven Enerbäck
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
Nature Communications
Sakaguchi, M, Cai, W, Wang, C-H, Cederquist, C T, Damasio, M, Homan, E P, Batista, T, Ramirez, A K, Gupta, M K, Steger, M, Wewer Albrechtsen, N J, Singh, S K, Araki, E, Mann, M, Enerbäck, S & Kahn, C R 2019, ' FoxK1 and FoxK2 in insulin regulation of cellular and mitochondrial metabolism ', Nature Communications, vol. 10, no. 1, 1582 . https://doi.org/10.1038/s41467-019-09418-0
Nature Communications
Sakaguchi, M, Cai, W, Wang, C-H, Cederquist, C T, Damasio, M, Homan, E P, Batista, T, Ramirez, A K, Gupta, M K, Steger, M, Wewer Albrechtsen, N J, Singh, S K, Araki, E, Mann, M, Enerbäck, S & Kahn, C R 2019, ' FoxK1 and FoxK2 in insulin regulation of cellular and mitochondrial metabolism ', Nature Communications, vol. 10, no. 1, 1582 . https://doi.org/10.1038/s41467-019-09418-0
A major target of insulin signaling is the FoxO family of Forkhead transcription factors, which translocate from the nucleus to the cytoplasm following insulin-stimulated phosphorylation. Here we show that the Forkhead transcription factors FoxK1 and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c2ea2a65dfb089997f1d72b587591ed
https://doaj.org/article/6452f44069924205846a1027bdcd7038
https://doaj.org/article/6452f44069924205846a1027bdcd7038
Publikováno v:
The Journal of Biological Chemistry
Traditionally, lipolysis has been regarded as an enzymatic activity that liberates fatty acids as metabolic fuel. However, recent work has shown that novel substrates, including a variety of lipid compounds such as fatty acids and their derivatives,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::843afc812038c7071cb5c29c54353e0a
http://europepmc.org/articles/PMC7949114
http://europepmc.org/articles/PMC7949114
Autor:
Joshua D. Rabinowitz, Sven Enerbäck
Publikováno v:
Nat Metab
Lactate, perhaps the best-known metabolic waste product, was first isolated from sour milk, in which it is produced by lactobacilli. Whereas microbes also generate other fermentation products, such as ethanol or acetone, lactate dominates in mammals.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9460d0c660e813e0da8e792973ed2db3
https://pubmed.ncbi.nlm.nih.gov/32694798
https://pubmed.ncbi.nlm.nih.gov/32694798