Zobrazeno 1 - 10
of 78
pro vyhledávání: '"Svein G. Dahl"'
Publikováno v:
Current Medicinal Chemistry. 18:4651-4658
X-ray crystallography, structural bioinformatics and computational chemistry have become important techniques in the discovery and development of effective and safe new drugs. From a drug discovery point of view, membrane proteins are among the most
Publikováno v:
Journal of Molecular Modeling. 15:1155-1164
The dopamine (DAT), serotontin (SERT) and noradrenalin (NET) transporters are molecular targets for different classes of psychotropic drugs. The crystal structure of Aquifex aeolicus LeuT(Aa) was used as a template for molecular modeling of DAT, SERT
Autor:
Ingebrigt Sylte, Svein G. Dahl
Publikováno v:
Journal of Psychopharmacology. 20:95-99
The era of molecular biology and cloning brought new knowledge about the structure and function of drug receptors, and demonstrated that the term ‘receptor’ must be distinguished from other molecular drug targets such as enzymes, transporters and
Publikováno v:
Bioorganic & Medicinal Chemistry. 14:666-675
Structural information about monoamine transporters and their interactions with psychotropic drugs is important for understanding their molecular mechanisms of action and for drug development. The crystal structure of a Major Facilitator Superfamily
Publikováno v:
Pharmaceutical Research. 22:1432-1437
In recent years, pharmacokinetic/pharmacodynamic (PK/PD) modeling has developed from an empirical descriptive discipline into a mechanistic science that can be applied at all stages of drug development. Mechanism-based PK/PD models differ from empiri
Publikováno v:
European Journal of Medicinal Chemistry. 40:185-194
A model of the dopamine D2 receptor was used to study the receptor interactions of dopamine, the typical antipsychotics haloperidol and loxapine, and the atypical antipsychotics clozapine and melperone. The atypical antipsychotics interacted with the
This book contains the papers from invited lecturers as well as selected contributions presented at the 6th International Meeting on Clinical Pharmacology in Psychiatry (I.M.C.P.P.) held in Geneva, Switzerland, 5-7 June 1991. At this meeting the basi
Publikováno v:
Journal of Computer-Aided Molecular Design. 17:367-382
The dopamine transporter (DAT) regulates the action of dopamine by reuptake of the neurotransmitter into presynaptic neurons, and is the main molecular target of amphetamines and cocaine. DAT and the Na+/H+ antiporter (NhaA) are secondary transporter
Publikováno v:
Bioorganic & Medicinal Chemistry. 7:2737-2748
A three-dimensional model of the human neuropeptide Y(NPY)Y1 receptor (hY1) was constructed, energy refined and used to simulate molecular receptor interactions of the peptide ligands NPY, [L31, P34]NPY, peptide YY (PYY) and pancreatic polypeptide (P
The Fourth International Meeting on Clinical Pharmacology in Psychiatry was held in Bethesda, Maryland on 5-8 September 1985 and was dedicated to the memory of Dr. Earl Usdin. Earl was one of the organizers of the three previous meetings held in Chic