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Antibodies targeting the human PDGF receptor, the AAV-5 and the AAV-9 and uses thereof

Autor: AVVEDIMENTO, VITTORIO ENRICO, SANTILLO, MARIAROSARIA, Gabrielli A., M.o.r.o.n.c.i.n.i.G., Svegliati S., Funaro A., Paternò R.

Authors generated agonistic and non-agonistic recombinant human monoclonal auto-antibodies (rHu-maab) directed to Platelet Derived Growth Factor Receptor (PDGFR). These novel reagents were employed to define the map of PDGFR functional domains involv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3730::6e767bbb2c3ae942c3454df526497465
http://hdl.handle.net/11588/413824

Method to diagnose an autoimmune disease and to identify and isolate stimulatory molecules

Autor: AVVEDIMENTO, VITTORIO ENRICO, PATERNO', ROBERTO, SANTILLO, MARIAROSARIA, Gabrielli A., Lucchetti M., Svegliati S., Curcio F.

The present invention relates to a method for the diagnosis of autoimmune diseases, as for example, rheumatoid arthritis, multiple sclerosis, Graves disease and lungfibrosis, based on the increase ofmore than one molecular species in a suitable cell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3730::7980ad1b1077b0f9122b3d21abc24d6d
http://hdl.handle.net/11588/423996

Platelet-derived growth factor and reactive oxygen species (ROS) regulate Ras protein levels in primary human fibroblasts via ERK1/2. Amplification of ROS and Ras in systemic sclerosis fibroblasts

Autor: Svegliati S, Cancello R, Sambo P, Luchetti M, Paroncini P, Orlandini G, Discepoli G, Paterno R, Cuozzo C, Cassano S, Avvedimento EV, Gabrielli A., SANTILLO, MARIAROSARIA

Publikováno v: The Journal of biological chemistry
280 (2005): 36474–36482.
info:cnr-pdr/source/autori:Svegliati S; Cancello R; Sambo P; Luchetti M; Paroncini P; Orlandini G; Discepoli G; Paterno R; Santillo M; Cuozzo C; Cassano S; Avvedimento EV; Gabrielli A./titolo:Platelet-derived growth factor and reactive oxygen species (ROS) regulate Ras protein levels in primary human fibroblasts via ERK1%2F2. Amplification of ROS and Ras in systemic sclerosis fibroblasts./doi:/rivista:The Journal of biological chemistry (Print)/anno:2005/pagina_da:36474/pagina_a:36482/intervallo_pagine:36474–36482/volume:280

The levels of Ras proteins in human primary fibroblasts are regulated by PDGF (platelet-derived growth factor). PDGF induced post-transcriptionally Ha-Ras by stimulating reactive oxygen species (ROS) and ERK1/2. Activation of ERK1/2 and high ROS leve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::2455dcdc5866a5ae0d2552e87b9923fc
https://pubmed.ncbi.nlm.nih.gov/16081426

AUTOIMMUNITY TO PDGFR: A RELEVANT PATHOGENIC LINK IN SSc

Autor: Moroncini, G., Grieco, A., Paolini, C., Nacci, Giulia, Pozniak, K., Mori, S., Finke, D., Cuccioloni, M., Mozzicafreddo, M., Tonnini, C., Svegliati, S., Angeletti, M., Avvedimento, E., Funaro, Ada, Gabrielli, A.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______970::4fff78dfdd8ce4e9af2ab6e68cc79f7e
http://hdl.handle.net/2318/120952