Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Svasti Haricharan"'
Autor:
Elham Sajjadi, Konstantinos Venetis, Roberto Piciotti, Marco Invernizzi, Elena Guerini-Rocco, Svasti Haricharan, Nicola Fusco
Publikováno v:
Cancer Cell International, Vol 21, Iss 1, Pp 1-10 (2021)
Abstract The clinical outcome of patients with a diagnosis of hormone receptor (HR)+ breast cancer has improved remarkably since the arrival of endocrine therapy. Yet, resistance to standard treatments is a major clinical challenge for breast cancer
Externí odkaz:
https://doaj.org/article/a3ee48279ec747ff8d2483301e7d8db3
Autor:
Nindo B. Punturi, Sinem Seker, Vaishnavi Devarakonda, Aloran Mazumder, Rashi Kalra, Ching Hui Chen, Shunqiang Li, Tina Primeau, Matthew J. Ellis, Shyam M. Kavuri, Svasti Haricharan
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Resistance to endocrine treatment in ER+/HER2- breast cancer patients remains a significant clinical problem. Here, the authors demonstrate that loss of the MutL mismatch repair complex can serve as a first-in-class predictive biomarker for combinato
Externí odkaz:
https://doaj.org/article/65ef3b7f9a184674b715885b4857dafc
Autor:
Aloran Mazumder, Athena Jimenez, Rachel E. Ellsworth, Stephen J. Freedland, Sophia George, Matthew N. Bainbridge, Svasti Haricharan
Publikováno v:
Therapeutic Advances in Medical Oncology, Vol 14 (2022)
Background: Estrogen receptor positive (ER+) breast cancer is one of the most commonly diagnosed malignancies in women irrespective of their race or ethnicity. While Black women with ER+ breast cancer are 42% more likely to die of their disease than
Externí odkaz:
https://doaj.org/article/828661038c0b4fb98a838449cb6e2175
Autor:
Jonathan T. Lei, Jieya Shao, Jin Zhang, Michael Iglesia, Doug W. Chan, Jin Cao, Meenakshi Anurag, Purba Singh, Xiaping He, Yoshimasa Kosaka, Ryoichi Matsunuma, Robert Crowder, Jeremy Hoog, Chanpheng Phommaly, Rodrigo Goncalves, Susana Ramalho, Raquel Mary Rodrigues Peres, Nindo Punturi, Cheryl Schmidt, Alex Bartram, Eric Jou, Vaishnavi Devarakonda, Kimberly R. Holloway, W. Victoria Lai, Oliver Hampton, Anna Rogers, Ethan Tobias, Poojan A. Parikh, Sherri R. Davies, Shunqiang Li, Cynthia X. Ma, Vera J. Suman, Kelly K. Hunt, Mark A. Watson, Katherine A. Hoadley, E. Aubrey Thompson, Xi Chen, Shyam M. Kavuri, Chad J. Creighton, Christopher A. Maher, Charles M. Perou, Svasti Haricharan, Matthew J. Ellis
Publikováno v:
Cell Reports, Vol 24, Iss 6, Pp 1434-1444.e7 (2018)
Summary: RNA sequencing (RNA-seq) detects estrogen receptor alpha gene (ESR1) fusion transcripts in estrogen receptor-positive (ER+) breast cancer, but their role in disease pathogenesis remains unclear. We examined multiple ESR1 fusions and found th
Externí odkaz:
https://doaj.org/article/b6b75cb5a81b49bf90d37ac3366f6ea7
Autor:
Svasti Haricharan, Jie Dong, Sarah Hein, Jay P Reddy, Zhijun Du, Michael Toneff, Kimberly Holloway, Susan G Hilsenbeck, Shixia Huang, Rachel Atkinson, Wendy Woodward, Sonali Jindal, Virginia F Borges, Carolina Gutierrez, Hong Zhang, Pepper J Schedin, C Kent Osborne, David J Tweardy, Yi Li
Publikováno v:
eLife, Vol 2 (2013)
While a first pregnancy before age 22 lowers breast cancer risk, a pregnancy after age 35 significantly increases life-long breast cancer risk. Pregnancy causes several changes to the normal breast that raise barriers to transformation, but how pregn
Externí odkaz:
https://doaj.org/article/94eb7a23549b45968aeb7dc547d9391c
Autor:
Christopher R Lopez, Albert Ribes-Zamora, Sandra M Indiviglio, Christopher L Williams, Svasti Haricharan, Alison A Bertuch
Publikováno v:
PLoS Genetics, Vol 7, Iss 8, p e1002233 (2011)
The Ku heterodimer associates with the Saccharomyces cerevisiae telomere, where it impacts several aspects of telomere structure and function. Although Ku avidly binds DNA ends via a preformed channel, its ability to associate with telomeres via this
Externí odkaz:
https://doaj.org/article/96f0b3a85efb44979158bc1924f4785e
Autor:
Gianni Liti, Svasti Haricharan, Francisco A Cubillos, Anna L Tierney, Sarah Sharp, Alison A Bertuch, Leopold Parts, Elizabeth Bailes, Edward J Louis
Publikováno v:
PLoS Genetics, Vol 5, Iss 9, p e1000659 (2009)
In yeast, as in humans, telomere length varies among individuals and is controlled by multiple loci. In a quest to define the extent of variation in telomere length, we screened 112 wild-type Saccharomyces sensu stricto isolates. We found extensive t
Externí odkaz:
https://doaj.org/article/1edea827e5b14ad78c654610ced53e34
Autor:
Sinem Seker, Elena Oropeza, Sabrina Carrel, Aloran Mazumder, Nindo Punturi, Jonathan Lei, Meenakshi Anurag, Bora Lim, Matthew Bainbridge, Svasti Haricharan
Publikováno v:
Cancer Research. 83:P3-10
Cell cycle dysregulation is a prerequisite for cancer formation. However, whether the type of cell cycle dysregulation event a cell incurs during transformation to malignancy influences the type of cancer that evolves or clinical outcome is unknown.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::db61a2d3c26dc1c01c4b5709e28b6e4b
https://doi.org/10.1158/1538-7445.sabcs22-p3-10-02
https://doi.org/10.1158/1538-7445.sabcs22-p3-10-02
Autor:
Matthew J. Ellis, Cynthia X. Ma, Matthew N. Bainbridge, Shyam M. Kavuri, Dean P. Edwards, Shixia Huang, Shunqiang Li, Jeremy Hoog, John A. Olson, Kelly Hunt, Vera Suman, Jonathan T. Lei, Cheryl Schmidt, Jacob Schmelz, Meenakshi Anurag, Kimberly R. Holloway, Purba Singh, Nindo Punturi, Svasti Haricharan
Supplementary Figure 1 Mismatch repair dysregulation associates with high mutation load and poor clinical outcome in patients with ER breast cancer. Supplementary Figure 2 MutL complex disruption in ER breast cancer cells induces endocrine therapy re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05970a01cada46f0846e2266df7f4d18
https://doi.org/10.1158/2159-8290.22531617.v1
https://doi.org/10.1158/2159-8290.22531617.v1
Autor:
Svasti Haricharan, Matthew J. Ellis, Matthew N. Bainbridge, Jeremy Hoog, Nindo Punturi, Meenakshi Anurag
Supplementary Figures with legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdd1b70c99219c9a0ca9974f1f7439d8
https://doi.org/10.1158/1078-0432.22470740
https://doi.org/10.1158/1078-0432.22470740