Zobrazeno 1 - 10
of 86
pro vyhledávání: '"Svante Hermodsson"'
Autor:
Svante Hermodsson, Tore Wesslén
Publikováno v:
Acta Pathologica Microbiologica Scandinavica. 42:371-379
Publikováno v:
Acta Pathologica Microbiologica Scandinavica. 51:75-80
NK cell-mediated killing of AML blasts: role of histamine, monocytes and reactive oxygen metabolites
Publikováno v:
Europe PubMed Central
Blasts recovered from patients with acute myelogenous leukaemia (AML) were lysed by heterologous natural killer (NK) cells treated with NK cell-activating cytokines such as interleukin-2 (IL-2) or interferon-alpha (IFN-alpha). The cytokine-induced ki
Autor:
Frida Ewald Sander, Ebru Aydin, Hanna Grauers Wiktorin, Anders Ståhlberg, Svante Hermodsson, Fredrik B. Thorén, Brianna Lenox, Anna Martner, Johan Aurelius, Kristoffer Hellstrand
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 194(10)
The efficiency of immune-mediated clearance of cancer cells is hampered by immunosuppressive mediators in the malignant microenvironment, including NADPH oxidase–derived reactive oxygen species. We aimed at defining the effects of histamine, an inh
Publikováno v:
Journal of Leukocyte Biology. 76:1207-1213
A significant part of the therapeutic benefit of interferon-α (IFN-α) therapy in malignant diseases and in chronic viral infections is assumed to result from activation of lymphocytes with natural killer (NK) and T cell phenotype. In tumor tissue a
Publikováno v:
Scandinavian Journal of Immunology. 58:321-326
The vasoactive amine histamine is found at high concentrations in the immune and inflammatory tissues. Earlier studies have revealed that histamine regulates the nicotinamide-adenine dinucleotide phosphate (NADPH) oxidase-dependent formation of oxyge
Autor:
Svante Hermodsson, Per Lindnér, Claes Dahlgren, Kristoffer Hellstrand, Markus Hansson, Peter Naredi, Mats Brune, Ulf-Henrik Mellqvist
Publikováno v:
Medical Oncology. 17:258-269
Interleukin-2 is a remarkable activator of lymphocytes with anti-neoplastic properties such as T-cells or natural killer cells, but tumor regression only rarely occurs in interleukin-2-treated cancer patients. In this review, we focus on interactions
Publikováno v:
Seminars in Cancer Biology. 10:29-39
Interleukin-2 (IL-2) is an effective activator of lymphocytes with anti-neoplastic properties such as T-cells or natural killer cells, and this property of IL-2 has formed the basis for its widespread used as an immunotherapeutic agent in human neopl
Autor:
Mats Brune, Peter Naredi, Kurt R. Gehlsen, Markus Hansson, Svante Hermodsson, Ulf-Henrik Mellqvist, Kristoffer Hellstrand
Publikováno v:
Cancer Investigation. 18:347-355
The functions of intratumoral lymphocytes in many human malignant tumors are inhibited by reactive oxygen species (ROS), generated by adjacent monocytes/macrophages (MO). In vitro data suggest that immunotherapeutic cytokines such as interleukin-2 (I
Autor:
Peter Naredi, Mats Brune, Kurt R. Gehlsen, Kristoffer Hellstrand, Svante Hermodsson, Ulf-Henrik Mellqvist, Åsa Betten, Markus Hansson
Publikováno v:
Journal of Interferon & Cytokine Research. 19:1135-1144
Oxidative stress inflicted by monocytes/macrophages (MO) is recognized as an important immunosuppressive mechanism in human neoplastic disease. We report that two types of lymphocytes of relevance for protection against malignant cells, T cells and n