Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Suzy, Coustal"'
Publikováno v:
Bioorganic & Medicinal Chemistry. 6:1781-1788
18-Vinylprogesterone (18-VP) and 18-ethynylprogesterone (18-EP) have proved to be potent suicide inhibitors of P-450(11) beta, the last enzyme of aldosterone biosynthesis (Delorme, C.; Piffeteau, A.; Viger, A.; Marquet, A. Eur. J. Biochem. 1995, 232,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15548ced8e77c231093ac04b380307e0
https://doi.org/10.1016/s0968-0896(98)00106-0
https://doi.org/10.1016/s0968-0896(98)00106-0
Publikováno v:
Tetrahedron. 51:3559-3570
Cytochrome P-450 11β is a key enzyme in the biosynthesis of aldosterone which catalyzes the transformation of 11-deoxycorticosterone (DOC) to aldosterone via three successive hydroxylations (at C-11 and at C-18). This enzyme is irreversibly inactiva
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::476b71e75f5ac333175ce046eea7af46
https://doi.org/10.1016/0040-4020(95)00099-t
https://doi.org/10.1016/0040-4020(95)00099-t
Publikováno v:
Journal of Crystallographic and Spectroscopic Research. 20:429-432
The crystal structure of 18-cyanoprogesterone was determined by X-ray diffraction methods:P212121a=7.436(2),b=11.322(2),c=22.642(2) A. The structure was solved usingShelx-86. Final conventionalR=0.054.Rw=0.051 for 1841 reflections. TheA ring has an i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7be7a8611ef9ab04ff4271347de8a1fc
https://doi.org/10.1007/bf01180109
https://doi.org/10.1007/bf01180109
Publikováno v:
Journal of Steroid Biochemistry. 30:469-472
A new family of aldosterone biosynthesis inhibitors, designed as 18-mono-oxygenase, cytochrome-P450-dependent, potential Kcat inhibitors, is described. These compounds are progesterone derivatives substituted at the 18-methyl group. Preliminary resul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6911e596af4b22b7bbe18b435a52283e
https://doi.org/10.1016/0022-4731(88)90145-8
https://doi.org/10.1016/0022-4731(88)90145-8
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Enzymology. 660:170-173
The mechanism of the isomerization of androst-5-ene 3,17-dione by the isomerase of bovine adrenals has been reinvestigated using the methodology previously developed for the study of the bacterial enzyme of Pseudomonas testosteroni. However, owing to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbb477d04b36697a7525b1d964ed8420
https://doi.org/10.1016/0005-2744(81)90156-x
https://doi.org/10.1016/0005-2744(81)90156-x
Publikováno v:
Journal of Steroid Biochemistry. 33:119-124
The synthesis of new progesterone derivatives substituted at the 18 methyl group is described. These compounds are designed as 18-monooxygenase, cytochrome P-450-dependent potential kcat inhibitors. Preliminary results on the in vitro biological inve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::727d679ccb399013b2deec5422e3e7e3
https://doi.org/10.1016/0022-4731(89)90366-x
https://doi.org/10.1016/0022-4731(89)90366-x
Publikováno v:
Analytical biochemistry. 128(2)
d-Biotin, dethiobiotin, d-biotin sulfoxides, and d-biotin sulfone are converted to uv-absorbing or fluorescent derivatives by reaction with ω-4-dibromoacetophenone or 4-bromomethyl methoxy coumarin. High-performance liquid chromatographic separation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::602abf29114fba250e086ae696f26af3
https://pubmed.ncbi.nlm.nih.gov/6846813
https://pubmed.ncbi.nlm.nih.gov/6846813
Publikováno v:
In Tetrahedron 1991 47(35):7309-7322