Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Suzumi M Tokuoka"'
Autor:
Takatoshi Uchida, Shota Shimizu, Reiko Yamagishi, Suzumi M Tokuoka, Yoshihiro Kita, Rei Sakata, Megumi Honjo, Makoto Aihara
Publikováno v:
PLoS ONE, Vol 16, Iss 10, p e0258911 (2021)
Trabecular meshwork constitutes the conventional outflow pathway and controls intraocular pressure by regulating aqueous outflow. Mechanical stimulation has been studied as one of the triggers to regulate aqueous outflow in trabecular meshwork, but i
Externí odkaz:
https://doaj.org/article/8f21891e3fc246dcaaef2b5d7a54f8db
Publikováno v:
PLoS ONE, Vol 14, Iss 12, p e0226073 (2019)
The isobaric tagging method widely used in proteomic and lipidomic fields, with the multiple reaction monitoring (MRM) approach using a triple quadrupole mass spectrometer, was applied to identify biomarker candidates from plasma samples for Alzheime
Externí odkaz:
https://doaj.org/article/c02fabe2592a4fbba4ed342341ffe6cb
Autor:
Suzumi M. Tokuoka, Fumie Hamano, Ayako Kobayashi, Shungo Adachi, Tomohiro Andou, Tohru Natsume, Yoshiya Oda
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Proximity Extension Assay (PEA) and mass spectrometry (MS) methodologies were utilized for the proteomic and lipidomic characterization of plasma specimens from patients who developed Alzheimer's disease. Proteomics was performed by both PEA
Externí odkaz:
https://doaj.org/article/99a993a8fa054e32a2a5ef34f10505f9
Autor:
Tomomi Hashidate-Yoshida, Takeshi Harayama, Daisuke Hishikawa, Ryo Morimoto, Fumie Hamano, Suzumi M Tokuoka, Miki Eto, Miwa Tamura-Nakano, Rieko Yanobu-Takanashi, Yoshiko Mukumoto, Hiroshi Kiyonari, Tadashi Okamura, Yoshihiro Kita, Hideo Shindou, Takao Shimizu
Publikováno v:
eLife, Vol 4 (2015)
Polyunsaturated fatty acids (PUFAs) in phospholipids affect the physical properties of membranes, but it is unclear which biological processes are influenced by their regulation. For example, the functions of membrane arachidonate that are independen
Externí odkaz:
https://doaj.org/article/e77477d61e2740d5a54c570fec3d11ef
Autor:
Yoshihiro Kita, Kenij Yoshida, Suzumi M Tokuoka, Fumie Hamano, Maya Yamazaki, Kenji Sakimura, Masanobu Kano, Takao Shimizu
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0133663 (2015)
Fever is a common response to inflammation and infection. The mechanism involves prostaglandin E2 (PGE2)-EP3 receptor signaling in the hypothalamus, which raises the set point of hypothalamic thermostat for body temperature, but the lipid metabolic p
Externí odkaz:
https://doaj.org/article/329e0e550b3e4d3fa2b03d3260cb6345
Autor:
Tetsuya Hirabayashi, Mai Kawaguchi, Sayaka Harada, Misa Mouri, Rina Takamiya, Yoshimi Miki, Hiroyasu Sato, Yoshitaka Taketomi, Kohei Yokoyama, Tetsuyuki Kobayashi, Suzumi M. Tokuoka, Yoshihiro Kita, Emiko Yoda, Shuntaro Hara, Kyohei Mikami, Yasumasa Nishito, Norihito Kikuchi, Rieko Nakata, Mari Kaneko, Hiroshi Kiyonari, Kohji Kasahara, Toshiki Aiba, Kazutaka Ikeda, Tomoyoshi Soga, Makoto Kurano, Yutaka Yatomi, Makoto Murakami
Publikováno v:
Cell Reports, Vol 42, Iss 2, Pp 111940- (2023)
Summary: Choline supplies methyl groups for regeneration of methionine and the methyl donor S-adenosylmethionine in the liver. Here, we report that the catabolism of membrane phosphatidylcholine (PC) into water-soluble glycerophosphocholine (GPC) by
Externí odkaz:
https://doaj.org/article/7ee32951ecd74122b19dbf4171b4e0c3
Autor:
Tatsuya Hosoi, Mitsutaka Yakabe, Hiroko Sasakawa, Takayoshi Sasako, Kohjiro Ueki, Shigeaki Kato, Suzumi M. Tokuoka, Yoshiya Oda, Masahiro Abe, Toshio Matsumoto, Masahiro Akishita, Sumito Ogawa
Publikováno v:
Proceedings of the National Academy of Sciences. 120
Sarcopenia is distinct from normal muscle atrophy in that it is closely related to a shift in the muscle fiber type. Deficiency of the anabolic action of androgen on skeletal muscles is associated with sarcopenia; however, the function of the androge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::182c85b4dca82e788b75408b8931f406
https://doi.org/10.1073/pnas.2218032120
https://doi.org/10.1073/pnas.2218032120
Autor:
Reiko Yamagishi, Suzumi M. Tokuoka, Makoto Aihara, Shota Shimizu, Yoshihiro Kita, Megumi Honjo, Takatoshi Uchida
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
The trabecular meshwork (TM) constitutes the main pathway for aqueous humor drainage and is exposed to complex intraocular pressure fluctuations. The mechanism of homeostasis in which TM senses changes in intraocular pressure and leads to normal leve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::342430f9dd37b5ff41a7d906f1b8cf7d
https://doaj.org/article/3a790bb7932047738f10802992a9fe8f
https://doaj.org/article/3a790bb7932047738f10802992a9fe8f
Autor:
Hiroaki Kitano, Masahiro Yamamoto, Noriko Kaifuchi, Ayako Yachie, Katsuya Ohbuchi, Akinori Nishi, Chika Shimobori, Yoshihiro Kita, Suzumi M. Tokuoka, Hirotaka Kushida, Yukiko Matsuoka
Publikováno v:
npj Systems Biology and Applications, Vol 7, Iss 1, Pp 1-6 (2021)
NPJ Systems Biology and Applications
NPJ Systems Biology and Applications
Lipid mediators are major factors in multiple biological functions and are strongly associated with disease. Recent lipidomics approaches have made it possible to analyze multiple metabolites and the associations of individual lipid mediators. Such s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f62b6d34a19188fe643abf0584f49cc4
https://doaj.org/article/7cb87851d61d409fb44ed690a98dcc1d
https://doaj.org/article/7cb87851d61d409fb44ed690a98dcc1d
Publikováno v:
Metabolites; Volume 12; Issue 4; Pages: 354
In targeted metabolomic analysis using liquid chromatography–multiple reaction monitoring–mass spectrometry (LC-MRM-MS), hundreds of MRMs are performed in a single run, yielding a large dataset containing thousands of chromatographic peaks. Autom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f377d9e456f3c5493dc1de325bff75ba